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Biological properties of garlic and garlic-derived organosulfur compounds.
Environ Mol Mutagen 2009; 50(3):247-65EM

Abstract

Medicinal properties of garlic (Allium sativum) have been widely known and used since ancient times till the present. Garlic enhances immune functions and has antibacterial, antifungal and antivirus activities. It is known to prevent platelet aggregation, and to have hypotensive and cholesterol- and triglyceride-lowering properties, although the latter features have been questioned. This review is focused on anticancer efficacy of Allium sativum, and attempts to explain the mechanisms of this action. Medicinal properties of garlic rely upon organosulfur compounds mostly derived from alliin. Organosulfur compounds originating from garlic inhibit carcinogen activation, boost phase 2 detoxifying processes, cause cell cycle arrest mostly in G2/M phase, stimulate the mitochondrial apoptotic pathway, increase acetylation of histones. Garlic-derived sulfur compounds influence also gap-junctional intercellular communication and participate in the development of multidrug resistance. This review presents also other little known aspects of molecular action of garlic-derived compounds, like modulation of cellular redox state, involvement in signal transduction and post-translational modification of proteins by sulfane sulfur or by formation of mixed disulfides (S-thiolation reactions).

Authors+Show Affiliations

Chair of Medical Biochemistry, Jagiellonian University, Medical College, Kraków, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19253339

Citation

Iciek, Małgorzata, et al. "Biological Properties of Garlic and Garlic-derived Organosulfur Compounds." Environmental and Molecular Mutagenesis, vol. 50, no. 3, 2009, pp. 247-65.
Iciek M, Kwiecień I, Włodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ Mol Mutagen. 2009;50(3):247-65.
Iciek, M., Kwiecień, I., & Włodek, L. (2009). Biological properties of garlic and garlic-derived organosulfur compounds. Environmental and Molecular Mutagenesis, 50(3), pp. 247-65. doi:10.1002/em.20474.
Iciek M, Kwiecień I, Włodek L. Biological Properties of Garlic and Garlic-derived Organosulfur Compounds. Environ Mol Mutagen. 2009;50(3):247-65. PubMed PMID: 19253339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biological properties of garlic and garlic-derived organosulfur compounds. AU - Iciek,Małgorzata, AU - Kwiecień,Inga, AU - Włodek,Lidia, PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/3/28/medline SP - 247 EP - 65 JF - Environmental and molecular mutagenesis JO - Environ. Mol. Mutagen. VL - 50 IS - 3 N2 - Medicinal properties of garlic (Allium sativum) have been widely known and used since ancient times till the present. Garlic enhances immune functions and has antibacterial, antifungal and antivirus activities. It is known to prevent platelet aggregation, and to have hypotensive and cholesterol- and triglyceride-lowering properties, although the latter features have been questioned. This review is focused on anticancer efficacy of Allium sativum, and attempts to explain the mechanisms of this action. Medicinal properties of garlic rely upon organosulfur compounds mostly derived from alliin. Organosulfur compounds originating from garlic inhibit carcinogen activation, boost phase 2 detoxifying processes, cause cell cycle arrest mostly in G2/M phase, stimulate the mitochondrial apoptotic pathway, increase acetylation of histones. Garlic-derived sulfur compounds influence also gap-junctional intercellular communication and participate in the development of multidrug resistance. This review presents also other little known aspects of molecular action of garlic-derived compounds, like modulation of cellular redox state, involvement in signal transduction and post-translational modification of proteins by sulfane sulfur or by formation of mixed disulfides (S-thiolation reactions). SN - 1098-2280 UR - https://www.unboundmedicine.com/medline/citation/19253339/Biological_properties_of_garlic_and_garlic_derived_organosulfur_compounds_ L2 - https://doi.org/10.1002/em.20474 DB - PRIME DP - Unbound Medicine ER -