Tags

Type your tag names separated by a space and hit enter

Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
J Periodontol. 2009 Mar; 80(3):364-71.JP

Abstract

BACKGROUND

It has been suggested that scaling and root planing of all pockets within a few hours and chlorhexidine treatments (full-mouth disinfection) may reduce the need for supplementary therapies. The aim of this study was to evaluate the clinical benefit of amoxicillin and metronidazole administered immediately after completion of full-mouth periodontal debridement in patients with chronic periodontitis.

METHODS

This was a single-center, double-masked, placebo-controlled, randomized longitudinal study of 6 months' duration. Fifty-one patients received full-mouth periodontal debridement, performed within 48 hours. Twenty-five subjects received metronidazole, 500 mg, and amoxicillin, 375 mg, three times a day for 7 days; 26 subjects received a placebo.

RESULTS

Forty-seven patients could be followed up to month 6. No differences in clinical parameters were noted before treatment. The overall mean probing depth decreased from 4.3 +/- 0.4 mm to 3.0 +/- 0.2 mm in the test group and from 4.4 +/- 0.4 mm to 3.1 +/- 0.3 mm in the control group (P = 0.05, difference between groups). More importantly, test subjects had a significantly lower mean number of persisting pockets >4 mm and bleeding on probing that required further treatment (P = 0.005): 6 months after full-mouth debridement plus antibiotics, only 0.4 +/- 0.8 persisting pockets were still present, whereas 3.0 +/- 4.3 persisting pockets were still present in the control group. The protective risk of the antibiotics for having more than one pocket deeper than 4 mm and bleeding on probing per subject after 6 months was 8.85.

CONCLUSION

Systemic metronidazole and amoxicillin significantly improved the 6-month clinical outcomes of full-mouth non-surgical periodontal debridement, thus significantly reducing the need for additional therapy.

Authors+Show Affiliations

Department of Periodontology, University of Geneva, Geneva, Switzerland. norbert.cionca@unige.chNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19254119

Citation

Cionca, Norbert, et al. "Amoxicillin and Metronidazole as an Adjunct to Full-mouth Scaling and Root Planing of Chronic Periodontitis." Journal of Periodontology, vol. 80, no. 3, 2009, pp. 364-71.
Cionca N, Giannopoulou C, Ugolotti G, et al. Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. J Periodontol. 2009;80(3):364-71.
Cionca, N., Giannopoulou, C., Ugolotti, G., & Mombelli, A. (2009). Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. Journal of Periodontology, 80(3), 364-71. https://doi.org/10.1902/jop.2009.080540
Cionca N, et al. Amoxicillin and Metronidazole as an Adjunct to Full-mouth Scaling and Root Planing of Chronic Periodontitis. J Periodontol. 2009;80(3):364-71. PubMed PMID: 19254119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. AU - Cionca,Norbert, AU - Giannopoulou,Catherine, AU - Ugolotti,Giovanni, AU - Mombelli,Andrea, PY - 2009/3/4/entrez PY - 2009/3/4/pubmed PY - 2009/8/6/medline SP - 364 EP - 71 JF - Journal of periodontology JO - J Periodontol VL - 80 IS - 3 N2 - BACKGROUND: It has been suggested that scaling and root planing of all pockets within a few hours and chlorhexidine treatments (full-mouth disinfection) may reduce the need for supplementary therapies. The aim of this study was to evaluate the clinical benefit of amoxicillin and metronidazole administered immediately after completion of full-mouth periodontal debridement in patients with chronic periodontitis. METHODS: This was a single-center, double-masked, placebo-controlled, randomized longitudinal study of 6 months' duration. Fifty-one patients received full-mouth periodontal debridement, performed within 48 hours. Twenty-five subjects received metronidazole, 500 mg, and amoxicillin, 375 mg, three times a day for 7 days; 26 subjects received a placebo. RESULTS: Forty-seven patients could be followed up to month 6. No differences in clinical parameters were noted before treatment. The overall mean probing depth decreased from 4.3 +/- 0.4 mm to 3.0 +/- 0.2 mm in the test group and from 4.4 +/- 0.4 mm to 3.1 +/- 0.3 mm in the control group (P = 0.05, difference between groups). More importantly, test subjects had a significantly lower mean number of persisting pockets >4 mm and bleeding on probing that required further treatment (P = 0.005): 6 months after full-mouth debridement plus antibiotics, only 0.4 +/- 0.8 persisting pockets were still present, whereas 3.0 +/- 4.3 persisting pockets were still present in the control group. The protective risk of the antibiotics for having more than one pocket deeper than 4 mm and bleeding on probing per subject after 6 months was 8.85. CONCLUSION: Systemic metronidazole and amoxicillin significantly improved the 6-month clinical outcomes of full-mouth non-surgical periodontal debridement, thus significantly reducing the need for additional therapy. SN - 0022-3492 UR - https://www.unboundmedicine.com/medline/citation/19254119/Amoxicillin_and_metronidazole_as_an_adjunct_to_full_mouth_scaling_and_root_planing_of_chronic_periodontitis_ L2 - https://doi.org/10.1902/jop.2009.080540 DB - PRIME DP - Unbound Medicine ER -