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Serum ferritin concentrations in Africans with low dietary iron.
Ann Hematol. 2009 Nov; 88(11):1131-6.AH

Abstract

In the setting of high dietary, several studies have provided evidence for a strong effect of both high dietary iron and an unidentified genetic locus on iron stores in Africans. To investigate whether these effects are discernible in the setting of low dietary iron, serum ferritin concentrations were measured in 194 Zimbabwean men >30 years of age and 299 postmenopausal women who consumed a non-iron-fortified diet and who did not drink iron-rich traditional beer or other alcoholic beverages. Comparisons were made with non-alcohol drinking African-Americans studied in the third National Health and Nutritional Examination Survey (NHANES III) who consume an iron-fortified diet. As stratified by age and sex, serum ferritin concentrations were significantly lower in the 493 Zimbabweans studied than in 1,380 comparable African-Americans (P < 0.0005). Nevertheless, nine Zimbabwean subjects (1.8% of all cases) had modestly elevated serum ferritin concentrations not associated with evidence of inflammation or hepatic dysfunction. These data suggest that mild serum ferritin concentration elevations may occur among Zimbabweans not exposed to high dietary iron and that iron fortification of the diet may have substantial effects on serum ferritin concentration.

Authors+Show Affiliations

Clinical Affairs, Oncology/Hematology, Ortho Biotech LLC, Bridgewater, NJ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19259672

Citation

Moyo, Victor M., et al. "Serum Ferritin Concentrations in Africans With Low Dietary Iron." Annals of Hematology, vol. 88, no. 11, 2009, pp. 1131-6.
Moyo VM, Mvundura E, Khumalo H, et al. Serum ferritin concentrations in Africans with low dietary iron. Ann Hematol. 2009;88(11):1131-6.
Moyo, V. M., Mvundura, E., Khumalo, H., Gangaidzo, I. T., Saungweme, T., Nouraie, M., Rouault, T. A., Gomo, Z. A., & Gordeuk, V. R. (2009). Serum ferritin concentrations in Africans with low dietary iron. Annals of Hematology, 88(11), 1131-6. https://doi.org/10.1007/s00277-009-0718-6
Moyo VM, et al. Serum Ferritin Concentrations in Africans With Low Dietary Iron. Ann Hematol. 2009;88(11):1131-6. PubMed PMID: 19259672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ferritin concentrations in Africans with low dietary iron. AU - Moyo,Victor M, AU - Mvundura,Elisha, AU - Khumalo,Hlosukwazi, AU - Gangaidzo,Innocent T, AU - Saungweme,Thokozile, AU - Nouraie,Mehdi, AU - Rouault,Tracey A, AU - Gomo,Zvenyika A R, AU - Gordeuk,Victor R, Y1 - 2009/03/04/ PY - 2008/12/04/received PY - 2009/02/18/accepted PY - 2009/3/5/entrez PY - 2009/3/5/pubmed PY - 2009/10/9/medline SP - 1131 EP - 6 JF - Annals of hematology JO - Ann Hematol VL - 88 IS - 11 N2 - In the setting of high dietary, several studies have provided evidence for a strong effect of both high dietary iron and an unidentified genetic locus on iron stores in Africans. To investigate whether these effects are discernible in the setting of low dietary iron, serum ferritin concentrations were measured in 194 Zimbabwean men >30 years of age and 299 postmenopausal women who consumed a non-iron-fortified diet and who did not drink iron-rich traditional beer or other alcoholic beverages. Comparisons were made with non-alcohol drinking African-Americans studied in the third National Health and Nutritional Examination Survey (NHANES III) who consume an iron-fortified diet. As stratified by age and sex, serum ferritin concentrations were significantly lower in the 493 Zimbabweans studied than in 1,380 comparable African-Americans (P < 0.0005). Nevertheless, nine Zimbabwean subjects (1.8% of all cases) had modestly elevated serum ferritin concentrations not associated with evidence of inflammation or hepatic dysfunction. These data suggest that mild serum ferritin concentration elevations may occur among Zimbabweans not exposed to high dietary iron and that iron fortification of the diet may have substantial effects on serum ferritin concentration. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/19259672/Serum_ferritin_concentrations_in_Africans_with_low_dietary_iron_ L2 - https://dx.doi.org/10.1007/s00277-009-0718-6 DB - PRIME DP - Unbound Medicine ER -