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[Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice].

Abstract

OBJECTIVE

To investigate antagonism effects of total flavonoids from Chrysanthemum morifolium. (TFCM) against lead induced oxidative injury.

METHOD

Ninety male mice were randomly divided into 9 groups. Mice except normal control group inject lead acetate every other day for 20 days. In the next 10 d, drugs were orally administrated to mice once a day. After the last aministration, mice were sacrificed and immediately subjected to necropsy. The concentration of lead, zinc and copper in blood, brain, liver and kidney were determined. The body weight, relative organ weight, antioxidant enzyme levels (GSH, GSH-Px, SOD and CAT) and lipid peroxidation products (MDA) were performed.

RESULT

TFCM might antagonize the decrease of body weight and the increase of organ weight/body weight ratio. The combined treatment with TFCM and DMSA can significantly lower the lead levels in blood, brain, liver and kidney. In contrast, lead concentration in mice treated with TFCM alone did not show significant change in these organs. The other trace elements such as zinc and copper had no significant decrease after TFCM or DMSA treatment. Middle and high-dose TFCM was more effective than DMSA in increasing the activity of GSH, GSH-Px, SOD, CAT and decreasing the concentration of MDA in mice brain. In addition, high-dose TFCM was more effective than DMSA in increasing the activity of GSH-Px, CAT and decreasing the concentration of MDA in mice liver and kidney. The combined treatment with TFCM and DMSA also can reverse lipid peroxidation and increase antioxidant enzyme levels in lead poisoning mice dose-dependently, and it had more beneficial effects than treatment with DMSA alone.

CONCLUSION

TFCM might improve antioxidant defense system, reverse lipid peroxidation and protect brain, liver and kidney against lead induced oxidative damage in mice significantly.

Authors+Show Affiliations

,

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. xdz1978@126.com

, , ,

Source

MeSH

Administration, Oral
Animals
Brain
Chrysanthemum
Copper
Drug Antagonism
Flavonoids
Kidney
Lead
Liver
Male
Mice
Mice, Inbred ICR
Oxidative Stress
Random Allocation
Succimer
Zinc

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19260317

Citation

Xia, Dao-zong, et al. "[Antagonism of Total Flavonoids From Chrysanthemum Morifolium Against Lead Induced Oxidative Injury in Mice]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 33, no. 23, 2008, pp. 2803-8.
Xia DZ, Lv GY, Yu XF, et al. [Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice]. Zhongguo Zhong Yao Za Zhi. 2008;33(23):2803-8.
Xia, D. Z., Lv, G. Y., Yu, X. F., Wang, H. M., & Yang, Q. (2008). [Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 33(23), pp. 2803-8.
Xia DZ, et al. [Antagonism of Total Flavonoids From Chrysanthemum Morifolium Against Lead Induced Oxidative Injury in Mice]. Zhongguo Zhong Yao Za Zhi. 2008;33(23):2803-8. PubMed PMID: 19260317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice]. AU - Xia,Dao-zong, AU - Lv,Gui-yuan, AU - Yu,Xin-fens, AU - Wang,Hui-ming, AU - Yang,Qing, PY - 2009/3/6/entrez PY - 2009/3/6/pubmed PY - 2009/5/14/medline SP - 2803 EP - 8 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 33 IS - 23 N2 - OBJECTIVE: To investigate antagonism effects of total flavonoids from Chrysanthemum morifolium. (TFCM) against lead induced oxidative injury. METHOD: Ninety male mice were randomly divided into 9 groups. Mice except normal control group inject lead acetate every other day for 20 days. In the next 10 d, drugs were orally administrated to mice once a day. After the last aministration, mice were sacrificed and immediately subjected to necropsy. The concentration of lead, zinc and copper in blood, brain, liver and kidney were determined. The body weight, relative organ weight, antioxidant enzyme levels (GSH, GSH-Px, SOD and CAT) and lipid peroxidation products (MDA) were performed. RESULT: TFCM might antagonize the decrease of body weight and the increase of organ weight/body weight ratio. The combined treatment with TFCM and DMSA can significantly lower the lead levels in blood, brain, liver and kidney. In contrast, lead concentration in mice treated with TFCM alone did not show significant change in these organs. The other trace elements such as zinc and copper had no significant decrease after TFCM or DMSA treatment. Middle and high-dose TFCM was more effective than DMSA in increasing the activity of GSH, GSH-Px, SOD, CAT and decreasing the concentration of MDA in mice brain. In addition, high-dose TFCM was more effective than DMSA in increasing the activity of GSH-Px, CAT and decreasing the concentration of MDA in mice liver and kidney. The combined treatment with TFCM and DMSA also can reverse lipid peroxidation and increase antioxidant enzyme levels in lead poisoning mice dose-dependently, and it had more beneficial effects than treatment with DMSA alone. CONCLUSION: TFCM might improve antioxidant defense system, reverse lipid peroxidation and protect brain, liver and kidney against lead induced oxidative damage in mice significantly. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/19260317/[Antagonism_of_total_flavonoids_from_Chrysanthemum_morifolium_against_lead_induced_oxidative_injury_in_mice]_ DB - PRIME DP - Unbound Medicine ER -