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Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome.
Fertil Steril. 2010 May 01; 93(7):2299-302.FS

Abstract

OBJECTIVE

To test whether the follicular fluid (FF) concentration of anti-Mullerian hormone (AMH) is associated with oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome (PCOS) undergoing IVF.

DESIGN

Prospective.

SETTING

Academic assisted reproductive technology program.

PATIENT(S)

Twenty-two samples of FF from 11 patients with PCOS who underwent IVF/ET were analyzed for AMH levels (group A). Twelve women with normal ovulatory cycles served as a control group (group B). The oocytes and preembryos were closely followed until ET.

METHOD(S)

FF was obtained at oocyte retrieval for IVF/intracytoplasmic sperm injection. AMH levels were studied using immunoenzymometric assay.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

FF, AMH levels, oocyte maturation, fertility rate, and embryonic cleavage rate.

RESULT(S)

The mean FF AMH level was 57.3 +/- 79.5 pmol/mL in group A, compared with 70 +/- 120.14 pmol/mL in group B. In group A, the mean AMH level of good-quality embryos was 37.4 +/- 23.4 pmol/mL, compared with 61.9 +/- 102 pmol/mL in a the poor-quality subgroup. No significant correlation was observed between FF AMH levels and oocyte maturation, fertilization, or cleavage rate.

CONCLUSION(S)

This study suggests that there is an association between FF AMH levels and the quality of embryos in patients with PCOS. However, owing to large variance and the number of participants, no statistical significance was reached. The degree of maturation of retrieved oocytes, as well as the success of fertilization, was not found to correlate with FF AMH.

Authors+Show Affiliations

IVF Unit, Department of Obstetrics and Gynecology, Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19261276

Citation

Mashiach, Roy, et al. "Follicular Fluid Levels of anti-Mullerian Hormone as a Predictor of Oocyte Maturation, Fertilization Rate, and Embryonic Development in Patients With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 93, no. 7, 2010, pp. 2299-302.
Mashiach R, Amit A, Hasson J, et al. Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome. Fertil Steril. 2010;93(7):2299-302.
Mashiach, R., Amit, A., Hasson, J., Amzalzg, S., Almog, B., Ben-Yosef, D., Lessing, J. B., Limor, R., & Azem, F. (2010). Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome. Fertility and Sterility, 93(7), 2299-302. https://doi.org/10.1016/j.fertnstert.2009.01.125
Mashiach R, et al. Follicular Fluid Levels of anti-Mullerian Hormone as a Predictor of Oocyte Maturation, Fertilization Rate, and Embryonic Development in Patients With Polycystic Ovary Syndrome. Fertil Steril. 2010 May 1;93(7):2299-302. PubMed PMID: 19261276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome. AU - Mashiach,Roy, AU - Amit,Ami, AU - Hasson,Joseph, AU - Amzalzg,Sagi, AU - Almog,Beni, AU - Ben-Yosef,Dalit, AU - Lessing,Joseph B, AU - Limor,Rona, AU - Azem,Foad, Y1 - 2009/03/03/ PY - 2008/05/17/received PY - 2009/01/21/revised PY - 2009/01/21/accepted PY - 2009/3/6/entrez PY - 2009/3/6/pubmed PY - 2010/5/26/medline SP - 2299 EP - 302 JF - Fertility and sterility JO - Fertil Steril VL - 93 IS - 7 N2 - OBJECTIVE: To test whether the follicular fluid (FF) concentration of anti-Mullerian hormone (AMH) is associated with oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome (PCOS) undergoing IVF. DESIGN: Prospective. SETTING: Academic assisted reproductive technology program. PATIENT(S): Twenty-two samples of FF from 11 patients with PCOS who underwent IVF/ET were analyzed for AMH levels (group A). Twelve women with normal ovulatory cycles served as a control group (group B). The oocytes and preembryos were closely followed until ET. METHOD(S): FF was obtained at oocyte retrieval for IVF/intracytoplasmic sperm injection. AMH levels were studied using immunoenzymometric assay. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): FF, AMH levels, oocyte maturation, fertility rate, and embryonic cleavage rate. RESULT(S): The mean FF AMH level was 57.3 +/- 79.5 pmol/mL in group A, compared with 70 +/- 120.14 pmol/mL in group B. In group A, the mean AMH level of good-quality embryos was 37.4 +/- 23.4 pmol/mL, compared with 61.9 +/- 102 pmol/mL in a the poor-quality subgroup. No significant correlation was observed between FF AMH levels and oocyte maturation, fertilization, or cleavage rate. CONCLUSION(S): This study suggests that there is an association between FF AMH levels and the quality of embryos in patients with PCOS. However, owing to large variance and the number of participants, no statistical significance was reached. The degree of maturation of retrieved oocytes, as well as the success of fertilization, was not found to correlate with FF AMH. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19261276/Follicular_fluid_levels_of_anti_Mullerian_hormone_as_a_predictor_of_oocyte_maturation_fertilization_rate_and_embryonic_development_in_patients_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(09)00247-7 DB - PRIME DP - Unbound Medicine ER -