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The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: cardiovascular risks and adiponectin in IFG.

Abstract

We aimed to assess how metabolic profiles, surrogate markers of insulin resistance, and subclinical atherosclerosis are interrelated in subjects with impaired fasting glucose (IFG) and investigate whether the diagnosis of metabolic syndrome (MetS) further increases the risk of cardiovascular disease among subjects already at risk. We analyzed 1739 Korean subjects with IFG. The parameters of MetS, plasma adiponectin level, and pulse wave velocity (PWV) were assessed. Subjects with MetS had unfavorable metabolic parameters, lower adiponectin level, and higher peripheral PWV compared to those without MetS. Adiponectin correlated with fasting glucose, waist circumference, triglyceride, HDL-cholesterol, BMI, HOMA-IR, and the number of MetS components. In addition to blood pressure, peripheral PWV was associated with triglyceride, waist circumference, and the number of MetS components while aortic PWV correlated positively with fasting plasma glucose. Multiple linear regression analysis revealed that adiponectin correlated with HDL-cholesterol, HOMA-IR, fasting glucose, waist circumference, and triglyceride, peripheral PWV with blood pressure, body mass index, waist circumference, and the number of MetS components, and aortic PWV with fasting plasma glucose. In subjects with IFG, concurrent MetS increases PWV and has an unfavorable effect on cardiovascular risks, and these risks were further increased by additional MetS components.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

    , , , , , ,

    Source

    MeSH

    Adiponectin
    Adult
    Blood Glucose
    Blood Pressure
    Cardiovascular Diseases
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Cross-Sectional Studies
    Glucose Intolerance
    Humans
    Insulin
    Metabolic Syndrome
    Middle Aged
    Peripheral Vascular Diseases
    Pulse
    Risk Factors

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19261346

    Citation

    Nam, J S., et al. "The Association Between Pulse Wave Velocity and Metabolic Syndrome and Adiponectin in Patients With Impaired Fasting Glucose: Cardiovascular Risks and Adiponectin in IFG." Diabetes Research and Clinical Practice, vol. 84, no. 2, 2009, pp. 145-51.
    Nam JS, Park JS, Cho MH, et al. The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: cardiovascular risks and adiponectin in IFG. Diabetes Res Clin Pract. 2009;84(2):145-51.
    Nam, J. S., Park, J. S., Cho, M. H., Jee, S. H., Lee, H. S., Ahn, C. W., ... Kim, K. R. (2009). The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: cardiovascular risks and adiponectin in IFG. Diabetes Research and Clinical Practice, 84(2), pp. 145-51. doi:10.1016/j.diabres.2009.02.002.
    Nam JS, et al. The Association Between Pulse Wave Velocity and Metabolic Syndrome and Adiponectin in Patients With Impaired Fasting Glucose: Cardiovascular Risks and Adiponectin in IFG. Diabetes Res Clin Pract. 2009;84(2):145-51. PubMed PMID: 19261346.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: cardiovascular risks and adiponectin in IFG. AU - Nam,J S, AU - Park,J S, AU - Cho,M H, AU - Jee,S H, AU - Lee,H S, AU - Ahn,C W, AU - Lowe,W L,Jr AU - Kim,K R, Y1 - 2009/03/03/ PY - 2008/12/03/received PY - 2009/01/29/revised PY - 2009/02/03/accepted PY - 2009/3/6/entrez PY - 2009/3/6/pubmed PY - 2009/7/30/medline SP - 145 EP - 51 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 84 IS - 2 N2 - We aimed to assess how metabolic profiles, surrogate markers of insulin resistance, and subclinical atherosclerosis are interrelated in subjects with impaired fasting glucose (IFG) and investigate whether the diagnosis of metabolic syndrome (MetS) further increases the risk of cardiovascular disease among subjects already at risk. We analyzed 1739 Korean subjects with IFG. The parameters of MetS, plasma adiponectin level, and pulse wave velocity (PWV) were assessed. Subjects with MetS had unfavorable metabolic parameters, lower adiponectin level, and higher peripheral PWV compared to those without MetS. Adiponectin correlated with fasting glucose, waist circumference, triglyceride, HDL-cholesterol, BMI, HOMA-IR, and the number of MetS components. In addition to blood pressure, peripheral PWV was associated with triglyceride, waist circumference, and the number of MetS components while aortic PWV correlated positively with fasting plasma glucose. Multiple linear regression analysis revealed that adiponectin correlated with HDL-cholesterol, HOMA-IR, fasting glucose, waist circumference, and triglyceride, peripheral PWV with blood pressure, body mass index, waist circumference, and the number of MetS components, and aortic PWV with fasting plasma glucose. In subjects with IFG, concurrent MetS increases PWV and has an unfavorable effect on cardiovascular risks, and these risks were further increased by additional MetS components. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/19261346/The_association_between_pulse_wave_velocity_and_metabolic_syndrome_and_adiponectin_in_patients_with_impaired_fasting_glucose:_cardiovascular_risks_and_adiponectin_in_IFG_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(09)00068-0 DB - PRIME DP - Unbound Medicine ER -