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Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study.
Am J Clin Nutr. 2009 May; 89(5):1418-24.AJ

Abstract

BACKGROUND

Heterocyclic aromatic amines (HCAs), which arise from cooking meat and fish at high temperatures, may increase the risk of colorectal adenomas. Conversely, flavonoids might counteract the negative effects of HCAs.

OBJECTIVE

The association between dietary HCA intake and colorectal adenoma incidence was investigated in a prospective cohort study.

DESIGN

At recruitment (1994-1998), detailed information on diet, anthropometric measures, lifestyle, and medication use was assessed in 25,540 participants of the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort study. Dietary HCA intake was estimated by using information from food-frequency questionnaires on meat consumption, applied cooking methods, and preferred degree of browning. Until June 2007, 516 verified incident colorectal adenomas were identified. Participants with negative colonoscopy (n = 3966) were also included in the analytic cohort. Multivariate Cox proportional hazards regression was used to examine the association between colorectal adenoma risk and intake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline (DiMeIQx).

RESULTS

In multivariate analyses, the intake of PhIP as the most abundant dietary HCA was associated with an increased risk of colorectal adenoma (relative risk: 1.47; 95% CI: 1.13, 1.93; quartile 4 compared with quartile 1; P for trend = 0.002), but no statistically significant associations were observed for MeIQx and DiMeIQx intakes. In addition, adenoma risk also increased with the consumption of strongly or extremely browned meat (P for trend = 0.04). The association of PhIP intake with adenoma risk was most pronounced for small adenomas (P for trend = 0.01) and adenomas localized in the distal colon (P for trend = 0.002).

CONCLUSION

The results of this first European cohort study support data from case-control studies of a positive association between HCA intake and colorectal adenoma risk.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. s.rohrmann@dkfz-heidelberg.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19261727

Citation

Rohrmann, Sabine, et al. "Heterocyclic Aromatic Amine Intake Increases Colorectal Adenoma Risk: Findings From a Prospective European Cohort Study." The American Journal of Clinical Nutrition, vol. 89, no. 5, 2009, pp. 1418-24.
Rohrmann S, Hermann S, Linseisen J. Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study. Am J Clin Nutr. 2009;89(5):1418-24.
Rohrmann, S., Hermann, S., & Linseisen, J. (2009). Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study. The American Journal of Clinical Nutrition, 89(5), 1418-24. https://doi.org/10.3945/ajcn.2008.26658
Rohrmann S, Hermann S, Linseisen J. Heterocyclic Aromatic Amine Intake Increases Colorectal Adenoma Risk: Findings From a Prospective European Cohort Study. Am J Clin Nutr. 2009;89(5):1418-24. PubMed PMID: 19261727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study. AU - Rohrmann,Sabine, AU - Hermann,Silke, AU - Linseisen,Jakob, Y1 - 2009/03/04/ PY - 2009/3/6/entrez PY - 2009/3/6/pubmed PY - 2009/5/15/medline SP - 1418 EP - 24 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 89 IS - 5 N2 - BACKGROUND: Heterocyclic aromatic amines (HCAs), which arise from cooking meat and fish at high temperatures, may increase the risk of colorectal adenomas. Conversely, flavonoids might counteract the negative effects of HCAs. OBJECTIVE: The association between dietary HCA intake and colorectal adenoma incidence was investigated in a prospective cohort study. DESIGN: At recruitment (1994-1998), detailed information on diet, anthropometric measures, lifestyle, and medication use was assessed in 25,540 participants of the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort study. Dietary HCA intake was estimated by using information from food-frequency questionnaires on meat consumption, applied cooking methods, and preferred degree of browning. Until June 2007, 516 verified incident colorectal adenomas were identified. Participants with negative colonoscopy (n = 3966) were also included in the analytic cohort. Multivariate Cox proportional hazards regression was used to examine the association between colorectal adenoma risk and intake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline (DiMeIQx). RESULTS: In multivariate analyses, the intake of PhIP as the most abundant dietary HCA was associated with an increased risk of colorectal adenoma (relative risk: 1.47; 95% CI: 1.13, 1.93; quartile 4 compared with quartile 1; P for trend = 0.002), but no statistically significant associations were observed for MeIQx and DiMeIQx intakes. In addition, adenoma risk also increased with the consumption of strongly or extremely browned meat (P for trend = 0.04). The association of PhIP intake with adenoma risk was most pronounced for small adenomas (P for trend = 0.01) and adenomas localized in the distal colon (P for trend = 0.002). CONCLUSION: The results of this first European cohort study support data from case-control studies of a positive association between HCA intake and colorectal adenoma risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19261727/Heterocyclic_aromatic_amine_intake_increases_colorectal_adenoma_risk:_findings_from_a_prospective_European_cohort_study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26658 DB - PRIME DP - Unbound Medicine ER -