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Single-sample 99mTc-diethylenetriamine penta-acetate plasma clearance in advanced renal failure by the mean sojourn time approach.
Nucl Med Commun. 2009 Mar; 30(3):202-5.NM

Abstract

OBJECTIVES

The single-sample Tc-diethylenetriamine penta-acetate (DTPA) clearance method by Christensen and Groth is recommended by the Radionuclides in Nephrourology Committee on Renal Clearance for use in adults with an estimated glomerular filtration rate (GFR) > or = 30 ml/min. The purpose of this study was to test a new Tc-DTPA single-sample low clearance formula for GFR lesser than 30 ml/min.

METHODS

Twenty-one adult patients (29 investigations) were included. Reference clearance was calculated with both Cr-EDTA and Tc-DTPA according to Brøchner-Mortensen with samples drawn between 3 and 24 h. Single-sample clearance was calculated from a 24 h sample using the low clearance formula(Equation is included in full-text article.) C(t) is the activity of the tracer in the plasma sample t minutes after the injection and Q0 is the injected amount. ECV is the extracellular volume in ml defined as the distribution volume of the tracer. ECV is estimated from the body surface area as ECV=8116.6xbody surface area-28.2.

RESULTS

The mean difference between reference and Tc-DTPA single-sample clearance was -0.5 ml/min (SD 1.0 ml/min) for Tc-DTPA and -0.8 ml/min (SD 1.2 ml/min) for Cr-EDTA as reference clearance.

CONCLUSION

In adult patients it is possible, even with GFR lesser than 30 ml/min, to get an accurate determination of Tc-DTPA plasma clearance from a single sample using the mean sojourn time approach. The blood sample should be obtained about 24 h after injection of the GFR tracer.

Authors+Show Affiliations

Department of Clinical Physiology, Institution of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. Margareta.Gref@vll.seNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19262281

Citation

Gref, Margareta C., and Kjell H. Karp. "Single-sample 99mTc-diethylenetriamine Penta-acetate Plasma Clearance in Advanced Renal Failure By the Mean Sojourn Time Approach." Nuclear Medicine Communications, vol. 30, no. 3, 2009, pp. 202-5.
Gref MC, Karp KH. Single-sample 99mTc-diethylenetriamine penta-acetate plasma clearance in advanced renal failure by the mean sojourn time approach. Nucl Med Commun. 2009;30(3):202-5.
Gref, M. C., & Karp, K. H. (2009). Single-sample 99mTc-diethylenetriamine penta-acetate plasma clearance in advanced renal failure by the mean sojourn time approach. Nuclear Medicine Communications, 30(3), 202-5. https://doi.org/10.1097/MNM.0b013e328315e0c6
Gref MC, Karp KH. Single-sample 99mTc-diethylenetriamine Penta-acetate Plasma Clearance in Advanced Renal Failure By the Mean Sojourn Time Approach. Nucl Med Commun. 2009;30(3):202-5. PubMed PMID: 19262281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-sample 99mTc-diethylenetriamine penta-acetate plasma clearance in advanced renal failure by the mean sojourn time approach. AU - Gref,Margareta C, AU - Karp,Kjell H, PY - 2009/3/6/entrez PY - 2009/3/6/pubmed PY - 2009/6/6/medline SP - 202 EP - 5 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 30 IS - 3 N2 - OBJECTIVES: The single-sample Tc-diethylenetriamine penta-acetate (DTPA) clearance method by Christensen and Groth is recommended by the Radionuclides in Nephrourology Committee on Renal Clearance for use in adults with an estimated glomerular filtration rate (GFR) > or = 30 ml/min. The purpose of this study was to test a new Tc-DTPA single-sample low clearance formula for GFR lesser than 30 ml/min. METHODS: Twenty-one adult patients (29 investigations) were included. Reference clearance was calculated with both Cr-EDTA and Tc-DTPA according to Brøchner-Mortensen with samples drawn between 3 and 24 h. Single-sample clearance was calculated from a 24 h sample using the low clearance formula(Equation is included in full-text article.) C(t) is the activity of the tracer in the plasma sample t minutes after the injection and Q0 is the injected amount. ECV is the extracellular volume in ml defined as the distribution volume of the tracer. ECV is estimated from the body surface area as ECV=8116.6xbody surface area-28.2. RESULTS: The mean difference between reference and Tc-DTPA single-sample clearance was -0.5 ml/min (SD 1.0 ml/min) for Tc-DTPA and -0.8 ml/min (SD 1.2 ml/min) for Cr-EDTA as reference clearance. CONCLUSION: In adult patients it is possible, even with GFR lesser than 30 ml/min, to get an accurate determination of Tc-DTPA plasma clearance from a single sample using the mean sojourn time approach. The blood sample should be obtained about 24 h after injection of the GFR tracer. SN - 0143-3636 UR - https://www.unboundmedicine.com/medline/citation/19262281/Single_sample_99mTc_diethylenetriamine_penta_acetate_plasma_clearance_in_advanced_renal_failure_by_the_mean_sojourn_time_approach_ L2 - https://doi.org/10.1097/MNM.0b013e328315e0c6 DB - PRIME DP - Unbound Medicine ER -