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Functional dyspepsia and irritable bowel syndrome in patients with achalasia and its association with non-cardiac chest pain and a decreased health-related quality of life.
Scand J Gastroenterol. 2009; 44(6):687-91.SJ

Abstract

OBJECTIVE

In patients with achalasia, little is known about symptoms of the gastrointestinal tract other than the esophagus. The purpose of this study was to determine the prevalence of two functional disorders, functional dyspepsia (FD) and irritable bowel syndrome (IBS), in a group of treated achalasia patients and to assess the additional impact of these disorders on health-related quality of life (HRQoL).

MATERIAL AND METHODS

Questionnaires assessing the Rome II criteria for FD and IBS together with the Eckardt clinical symptom score and RAND-36 were sent to 171 treated achalasia patients.

RESULTS

Of these patients, 76.6% returned their questionnaires. In the group of achalasia patients, 23% fulfilled the criteria for FD (Dutch general population 13-14%), and 21% fulfilled the criteria for IBS (Dutch general population 1-6%). The prevalence of frequent chest pain (at least weekly) was higher in patients with FD and/or IBS than in those without these symptoms (54.2% versus 28.2%; p=0.004). Female patients with achalasia and with frequent chest pain showed a higher probability of fulfilling the FD and/or IBS criteria (adjusted OR 2.90 (1.18-7.14) and 3.35 (1.4-8.1), respectively; both with p <0.05). Patients fulfilling the FD and/or IBS criteria scored a lower HRQoL on the RAND-36 subscales--pain, social functioning, and vitality--as compared with patients not fulfilling these criteria (p <0.006). CONCLUSIONS; Symptoms of FD and IBS in patients with treated achalasia are common and have a negative impact on HRQoL. Therefore, this has to be included in the standard evaluation of achalasia patients. The association with chest pain suggests a mutual underlying mechanism.

Authors+Show Affiliations

Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands. r.frankhuisen@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19263270

Citation

Frankhuisen, Rutger, et al. "Functional Dyspepsia and Irritable Bowel Syndrome in Patients With Achalasia and Its Association With Non-cardiac Chest Pain and a Decreased Health-related Quality of Life." Scandinavian Journal of Gastroenterology, vol. 44, no. 6, 2009, pp. 687-91.
Frankhuisen R, Van Herwaarden MA, Heijkoop R, et al. Functional dyspepsia and irritable bowel syndrome in patients with achalasia and its association with non-cardiac chest pain and a decreased health-related quality of life. Scand J Gastroenterol. 2009;44(6):687-91.
Frankhuisen, R., Van Herwaarden, M. A., Heijkoop, R., Baron, A., Vermeijden, R., Smout, A. J., Gooszen, H. G., & Samsom, M. (2009). Functional dyspepsia and irritable bowel syndrome in patients with achalasia and its association with non-cardiac chest pain and a decreased health-related quality of life. Scandinavian Journal of Gastroenterology, 44(6), 687-91. https://doi.org/10.1080/00365520902783709
Frankhuisen R, et al. Functional Dyspepsia and Irritable Bowel Syndrome in Patients With Achalasia and Its Association With Non-cardiac Chest Pain and a Decreased Health-related Quality of Life. Scand J Gastroenterol. 2009;44(6):687-91. PubMed PMID: 19263270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional dyspepsia and irritable bowel syndrome in patients with achalasia and its association with non-cardiac chest pain and a decreased health-related quality of life. AU - Frankhuisen,Rutger, AU - Van Herwaarden,Margot A, AU - Heijkoop,Roy, AU - Baron,Astrid, AU - Vermeijden,Reinoud, AU - Smout,André J P M, AU - Gooszen,Hein G, AU - Samsom,Melvin, PY - 2009/3/6/entrez PY - 2009/3/6/pubmed PY - 2009/10/9/medline SP - 687 EP - 91 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 44 IS - 6 N2 - OBJECTIVE: In patients with achalasia, little is known about symptoms of the gastrointestinal tract other than the esophagus. The purpose of this study was to determine the prevalence of two functional disorders, functional dyspepsia (FD) and irritable bowel syndrome (IBS), in a group of treated achalasia patients and to assess the additional impact of these disorders on health-related quality of life (HRQoL). MATERIAL AND METHODS: Questionnaires assessing the Rome II criteria for FD and IBS together with the Eckardt clinical symptom score and RAND-36 were sent to 171 treated achalasia patients. RESULTS: Of these patients, 76.6% returned their questionnaires. In the group of achalasia patients, 23% fulfilled the criteria for FD (Dutch general population 13-14%), and 21% fulfilled the criteria for IBS (Dutch general population 1-6%). The prevalence of frequent chest pain (at least weekly) was higher in patients with FD and/or IBS than in those without these symptoms (54.2% versus 28.2%; p=0.004). Female patients with achalasia and with frequent chest pain showed a higher probability of fulfilling the FD and/or IBS criteria (adjusted OR 2.90 (1.18-7.14) and 3.35 (1.4-8.1), respectively; both with p <0.05). Patients fulfilling the FD and/or IBS criteria scored a lower HRQoL on the RAND-36 subscales--pain, social functioning, and vitality--as compared with patients not fulfilling these criteria (p <0.006). CONCLUSIONS; Symptoms of FD and IBS in patients with treated achalasia are common and have a negative impact on HRQoL. Therefore, this has to be included in the standard evaluation of achalasia patients. The association with chest pain suggests a mutual underlying mechanism. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/19263270/Functional_dyspepsia_and_irritable_bowel_syndrome_in_patients_with_achalasia_and_its_association_with_non_cardiac_chest_pain_and_a_decreased_health_related_quality_of_life_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365520902783709 DB - PRIME DP - Unbound Medicine ER -