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Features of ciguatera fish poisoning cases in Hong Kong 2004-2007.
Biomed Environ Sci. 2008 Dec; 21(6):521-7.BE

Abstract

OBJECTIVE

To review the clinical features and laboratory investigations of ciguatera patients in Hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera.

METHODS

Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in Hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins (CTXs) analysis.

RESULTS

Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate (10%-100%) was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive (<0.5 - 4.3 MU/20 mg ether extract) and directly linked to the corresponding ciguatera cases.

CONCLUSION

Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined. Further studies are needed to determine the risk of each class of CTXs (Pacific-, Indian- and Caribbean-CTXs) in Hong Kong.

Authors+Show Affiliations

Biotoxin Laboratory, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Shek Kip Mei, Kowloon, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19263809

Citation

Wong, Chun-Kwan, et al. "Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007." Biomedical and Environmental Sciences : BES, vol. 21, no. 6, 2008, pp. 521-7.
Wong CK, Hung P, Lee KL, et al. Features of ciguatera fish poisoning cases in Hong Kong 2004-2007. Biomed Environ Sci. 2008;21(6):521-7.
Wong, C. K., Hung, P., Lee, K. L., Mok, T., Chung, T., & Kam, K. M. (2008). Features of ciguatera fish poisoning cases in Hong Kong 2004-2007. Biomedical and Environmental Sciences : BES, 21(6), 521-7. https://doi.org/10.1016/S0895-3988(09)60012-X
Wong CK, et al. Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007. Biomed Environ Sci. 2008;21(6):521-7. PubMed PMID: 19263809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Features of ciguatera fish poisoning cases in Hong Kong 2004-2007. AU - Wong,Chun-Kwan, AU - Hung,Patricia, AU - Lee,Kellie L H, AU - Mok,Tina, AU - Chung,Thomas, AU - Kam,Kai-Man, PY - 2009/3/7/entrez PY - 2009/3/7/pubmed PY - 2009/4/7/medline SP - 521 EP - 7 JF - Biomedical and environmental sciences : BES JO - Biomed Environ Sci VL - 21 IS - 6 N2 - OBJECTIVE: To review the clinical features and laboratory investigations of ciguatera patients in Hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera. METHODS: Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in Hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins (CTXs) analysis. RESULTS: Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate (10%-100%) was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive (<0.5 - 4.3 MU/20 mg ether extract) and directly linked to the corresponding ciguatera cases. CONCLUSION: Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined. Further studies are needed to determine the risk of each class of CTXs (Pacific-, Indian- and Caribbean-CTXs) in Hong Kong. SN - 0895-3988 UR - https://www.unboundmedicine.com/medline/citation/19263809/Features_of_ciguatera_fish_poisoning_cases_in_Hong_Kong_2004_2007_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0895-3988(09)60012-X DB - PRIME DP - Unbound Medicine ER -