Tags

Type your tag names separated by a space and hit enter

Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression.
Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3535-41.IO

Abstract

PURPOSE

To evaluate the relationship between pattern electroretinogram (PERG) amplitude, macular and retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT), and visual field (VF) loss on standard automated perimetry (SAP) in eyes with temporal hemianopia from chiasmal compression.

METHODS

Forty-one eyes from 41 patients with permanent temporal VF defects from chiasmal compression and 41 healthy subjects underwent transient full-field and hemifield (temporal or nasal) stimulation PERG, SAP and time domain-OCT macular and RNFL thickness measurements. Comparisons were made using Student's t-test. Deviation from normal VF sensitivity for the central 18 degrees of VF was expressed in 1/Lambert units. Correlations between measurements were verified by linear regression analysis.

RESULTS

PERG and OCT measurements were significantly lower in eyes with temporal hemianopia than in normal eyes. A significant correlation was found between VF sensitivity loss and full-field or nasal, but not temporal, hemifield PERG amplitude. Likewise a significant correlation was found between VF sensitivity loss and most OCT parameters. No significant correlation was observed between OCT and PERG parameters, except for nasal hemifield amplitude. A significant correlation was observed between several macular and RNFL thickness parameters.

CONCLUSIONS

In patients with chiasmal compression, PERG amplitude and OCT thickness measurements were significant related to VF loss, but not to each other. OCT and PERG quantify neuronal loss differently, but both technologies are useful in understanding structure-function relationship in patients with chiasmal compression. (ClinicalTrials.gov number, NCT00553761).

Authors+Show Affiliations

Division of Ophthalmology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil. mlrmonteiro@terra.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19264884

Citation

Monteiro, Mário L R., et al. "Relationship Between Optical Coherence Tomography, Pattern Electroretinogram and Automated Perimetry in Eyes With Temporal Hemianopia From Chiasmal Compression." Investigative Ophthalmology & Visual Science, vol. 50, no. 8, 2009, pp. 3535-41.
Monteiro ML, Cunha LP, Costa-Cunha LV, et al. Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. Invest Ophthalmol Vis Sci. 2009;50(8):3535-41.
Monteiro, M. L., Cunha, L. P., Costa-Cunha, L. V., Maia, O. O., & Oyamada, M. K. (2009). Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. Investigative Ophthalmology & Visual Science, 50(8), 3535-41. https://doi.org/10.1167/iovs.08-3093
Monteiro ML, et al. Relationship Between Optical Coherence Tomography, Pattern Electroretinogram and Automated Perimetry in Eyes With Temporal Hemianopia From Chiasmal Compression. Invest Ophthalmol Vis Sci. 2009;50(8):3535-41. PubMed PMID: 19264884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. AU - Monteiro,Mário L R, AU - Cunha,Leonardo P, AU - Costa-Cunha,Luciana V F, AU - Maia,Otacílio O,Jr AU - Oyamada,Maria K, Y1 - 2009/03/05/ PY - 2009/3/7/entrez PY - 2009/3/7/pubmed PY - 2009/8/12/medline SP - 3535 EP - 41 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 50 IS - 8 N2 - PURPOSE: To evaluate the relationship between pattern electroretinogram (PERG) amplitude, macular and retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT), and visual field (VF) loss on standard automated perimetry (SAP) in eyes with temporal hemianopia from chiasmal compression. METHODS: Forty-one eyes from 41 patients with permanent temporal VF defects from chiasmal compression and 41 healthy subjects underwent transient full-field and hemifield (temporal or nasal) stimulation PERG, SAP and time domain-OCT macular and RNFL thickness measurements. Comparisons were made using Student's t-test. Deviation from normal VF sensitivity for the central 18 degrees of VF was expressed in 1/Lambert units. Correlations between measurements were verified by linear regression analysis. RESULTS: PERG and OCT measurements were significantly lower in eyes with temporal hemianopia than in normal eyes. A significant correlation was found between VF sensitivity loss and full-field or nasal, but not temporal, hemifield PERG amplitude. Likewise a significant correlation was found between VF sensitivity loss and most OCT parameters. No significant correlation was observed between OCT and PERG parameters, except for nasal hemifield amplitude. A significant correlation was observed between several macular and RNFL thickness parameters. CONCLUSIONS: In patients with chiasmal compression, PERG amplitude and OCT thickness measurements were significant related to VF loss, but not to each other. OCT and PERG quantify neuronal loss differently, but both technologies are useful in understanding structure-function relationship in patients with chiasmal compression. (ClinicalTrials.gov number, NCT00553761). SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/19264884/Relationship_between_optical_coherence_tomography_pattern_electroretinogram_and_automated_perimetry_in_eyes_with_temporal_hemianopia_from_chiasmal_compression_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.08-3093 DB - PRIME DP - Unbound Medicine ER -