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Molecularly imprinted polymer for solid-phase extraction of ephedrine and analogs from human plasma.
J Sep Sci. 2009 Apr; 32(7):1036-42.JS

Abstract

A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ephedrine from human plasma. The MIP synthesis was performed in chloroform with methacrylic acid as a functional monomer and the target alkaloid as a template molecule. The resulting MIP was applied to the selective extraction of ephedrine from a pure aqueous medium. A recovery about 74% was obtained using the MIP with only 7% on the nonimprinted polymer (NIP). A very straightforward selective SPE procedure was then successfully applied to the direct extraction of ephedrine from spiked human plasma with a high extraction recovery (68%) on the MIP with no recovery on the NIP. Moreover, the MIP was used for the selective extraction of catecholamine neurotransmitters, i.e. adrenaline and noradrenaline.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lasáková M
Department of Analytical Chemistry, University of Pardubice, Pardubice, Czech Republic.
Thiébaut D
No affiliation info available
Jandera P
No affiliation info available
Pichon V
No affiliation info available

MeSH

CalibrationChromatography, High Pressure LiquidEphedrineHumansMolecular ImprintingMolecular StructurePolymersSolid Phase Extraction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19266546

Citation

Lasáková, Martina, et al. "Molecularly Imprinted Polymer for Solid-phase Extraction of Ephedrine and Analogs From Human Plasma." Journal of Separation Science, vol. 32, no. 7, 2009, pp. 1036-42.
Lasáková M, Thiébaut D, Jandera P, et al. Molecularly imprinted polymer for solid-phase extraction of ephedrine and analogs from human plasma. J Sep Sci. 2009;32(7):1036-42.
Lasáková, M., Thiébaut, D., Jandera, P., & Pichon, V. (2009). Molecularly imprinted polymer for solid-phase extraction of ephedrine and analogs from human plasma. Journal of Separation Science, 32(7), 1036-42. https://doi.org/10.1002/jssc.200800684
Lasáková M, et al. Molecularly Imprinted Polymer for Solid-phase Extraction of Ephedrine and Analogs From Human Plasma. J Sep Sci. 2009;32(7):1036-42. PubMed PMID: 19266546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecularly imprinted polymer for solid-phase extraction of ephedrine and analogs from human plasma. AU - Lasáková,Martina, AU - Thiébaut,Didier, AU - Jandera,Pavel, AU - Pichon,Valérie, PY - 2009/3/7/entrez PY - 2009/3/7/pubmed PY - 2009/6/27/medline SP - 1036 EP - 42 JF - Journal of separation science JO - J Sep Sci VL - 32 IS - 7 N2 - A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ephedrine from human plasma. The MIP synthesis was performed in chloroform with methacrylic acid as a functional monomer and the target alkaloid as a template molecule. The resulting MIP was applied to the selective extraction of ephedrine from a pure aqueous medium. A recovery about 74% was obtained using the MIP with only 7% on the nonimprinted polymer (NIP). A very straightforward selective SPE procedure was then successfully applied to the direct extraction of ephedrine from spiked human plasma with a high extraction recovery (68%) on the MIP with no recovery on the NIP. Moreover, the MIP was used for the selective extraction of catecholamine neurotransmitters, i.e. adrenaline and noradrenaline. SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/19266546/Molecularly_imprinted_polymer_for_solid_phase_extraction_of_ephedrine_and_analogs_from_human_plasma_ L2 - https://doi.org/10.1002/jssc.200800684 DB - PRIME DP - Unbound Medicine ER -