Tags

Type your tag names separated by a space and hit enter

Development and release mechanism of diltiazem HCl prolonged release matrix tablets.
Drug Deliv. 2009 Feb; 16(2):67-74.DD

Abstract

A coated matrix tablet formulation has been used to develop controlled release diltiazem HCl (DIL) tablets. The developed drug delivery system provided prolonged drug release rates over a defined period of time. DIL tablets prepared using dry mixing and direct compression and the core consisted of hydrophilic and hydrophobic polymers such as hydroxypropylmethylcellulose (HPMC), Eudragits RLPO/RSPO, microcrystalline cellulose, and lactose. Tablets were coated with Eudragit NE 30D, and the influence of varying the inert hydrophobic polymers and the amount of the coating polymer were investigated. The release profile of the developed formulation was described by the Higuchi model. Stability trials up to 6 months displayed excellent reproducibility.

Links

Publisher Full Text

Authors+Show Affiliations

Boyapally H
Pharmaceutical Sciences, Greenwich University, Medway Campus, Chatham Maritime, Kent, UK.
Nukala RK
No affiliation info available
Douroumis D
No affiliation info available

MeSH

Acrylic ResinsBiological AvailabilityCelluloseDelayed-Action PreparationsDiltiazemDrug StabilityHydrophobic and Hydrophilic InteractionsHypromellose DerivativesKineticsLactoseMethacrylatesMethylcelluloseMicroscopy, Electron, ScanningModels, ChemicalPolymersTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19267297

Citation

Boyapally, Harikrishna, et al. "Development and Release Mechanism of Diltiazem HCl Prolonged Release Matrix Tablets." Drug Delivery, vol. 16, no. 2, 2009, pp. 67-74.
Boyapally H, Nukala RK, Douroumis D. Development and release mechanism of diltiazem HCl prolonged release matrix tablets. Drug Deliv. 2009;16(2):67-74.
Boyapally, H., Nukala, R. K., & Douroumis, D. (2009). Development and release mechanism of diltiazem HCl prolonged release matrix tablets. Drug Delivery, 16(2), 67-74. https://doi.org/10.1080/10717540802586220
Boyapally H, Nukala RK, Douroumis D. Development and Release Mechanism of Diltiazem HCl Prolonged Release Matrix Tablets. Drug Deliv. 2009;16(2):67-74. PubMed PMID: 19267297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and release mechanism of diltiazem HCl prolonged release matrix tablets. AU - Boyapally,Harikrishna, AU - Nukala,Ravi Kumar, AU - Douroumis,Dionysios, PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2009/6/13/medline SP - 67 EP - 74 JF - Drug delivery JO - Drug Deliv VL - 16 IS - 2 N2 - A coated matrix tablet formulation has been used to develop controlled release diltiazem HCl (DIL) tablets. The developed drug delivery system provided prolonged drug release rates over a defined period of time. DIL tablets prepared using dry mixing and direct compression and the core consisted of hydrophilic and hydrophobic polymers such as hydroxypropylmethylcellulose (HPMC), Eudragits RLPO/RSPO, microcrystalline cellulose, and lactose. Tablets were coated with Eudragit NE 30D, and the influence of varying the inert hydrophobic polymers and the amount of the coating polymer were investigated. The release profile of the developed formulation was described by the Higuchi model. Stability trials up to 6 months displayed excellent reproducibility. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/19267297/Development_and_release_mechanism_of_diltiazem_HCl_prolonged_release_matrix_tablets_ L2 - https://www.tandfonline.com/doi/full/10.1080/10717540802586220 DB - PRIME DP - Unbound Medicine ER -