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Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering.
Bioconjug Chem. 2009 Apr; 20(4):768-73.BC

Abstract

We present a novel nuclear targeting nanoprobe based on peptide functionalized gold nanoparticles and its surface-enhanced Raman scattering (SERS) in living cells. For the first time, we probe an original SERS signal from the living cell nucleus by using high-selectivity functionalized gold nanoparticles. The gold nanoparticles conjugated with SV-40 large T nuclear localization signal (NLS) peptide successfully enter the cell nucleus after the incubation with Hela cells and deliver the spatially localized chemical information of the nucleus, as well as the signature of chemicals that intruded subsequently. This new targeted nanoprobe is a nontoxic, biocompatible method for biological research, provided with multiple functions comprising subcellular targeting, intracellular imaging, and real-time SERS detection.

Authors+Show Affiliations

Wuhan University, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19267459

Citation

Xie, Wei, et al. "Nuclear Targeted Nanoprobe for Single Living Cell Detection By Surface-enhanced Raman Scattering." Bioconjugate Chemistry, vol. 20, no. 4, 2009, pp. 768-73.
Xie W, Wang L, Zhang Y, et al. Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering. Bioconjug Chem. 2009;20(4):768-73.
Xie, W., Wang, L., Zhang, Y., Su, L., Shen, A., Tan, J., & Hu, J. (2009). Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering. Bioconjugate Chemistry, 20(4), 768-73. https://doi.org/10.1021/bc800469g
Xie W, et al. Nuclear Targeted Nanoprobe for Single Living Cell Detection By Surface-enhanced Raman Scattering. Bioconjug Chem. 2009;20(4):768-73. PubMed PMID: 19267459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering. AU - Xie,Wei, AU - Wang,Li, AU - Zhang,Yuying, AU - Su,Le, AU - Shen,Aiguo, AU - Tan,Jinquan, AU - Hu,Jiming, PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2009/7/1/medline SP - 768 EP - 73 JF - Bioconjugate chemistry JO - Bioconjug Chem VL - 20 IS - 4 N2 - We present a novel nuclear targeting nanoprobe based on peptide functionalized gold nanoparticles and its surface-enhanced Raman scattering (SERS) in living cells. For the first time, we probe an original SERS signal from the living cell nucleus by using high-selectivity functionalized gold nanoparticles. The gold nanoparticles conjugated with SV-40 large T nuclear localization signal (NLS) peptide successfully enter the cell nucleus after the incubation with Hela cells and deliver the spatially localized chemical information of the nucleus, as well as the signature of chemicals that intruded subsequently. This new targeted nanoprobe is a nontoxic, biocompatible method for biological research, provided with multiple functions comprising subcellular targeting, intracellular imaging, and real-time SERS detection. SN - 1520-4812 UR - https://www.unboundmedicine.com/medline/citation/19267459/Nuclear_targeted_nanoprobe_for_single_living_cell_detection_by_surface_enhanced_Raman_scattering_ L2 - https://doi.org/10.1021/bc800469g DB - PRIME DP - Unbound Medicine ER -