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[Salmonella meningitis in newborns and infants. The importance of fluoroquinolones].
Arch Pediatr. 2008 Dec; 15 Suppl 3:S161-6.AP

Abstract

OBJECTIVES

To analyze the characteristics of the salmonella meningitis in new-borns and infants in France and sum up the complications and treatments.

PATIENTS AND METHODS

The observations were taken from the national observatory of bacterial meningitis in children. The medical reports from paediatric and neo-natal departments have been analysed for each patient.

RESULTS

The case reports concern 9 newborn babies and infants aged from twelve days to fifteen months (median 4 months). The initial clinical and biologic signs were not specific. Three children had had a digestive infection in the previous weeks, with a positive coproculture for salmonella in two of them. Two infants developed convulsions : 1 of them was hospitalized in intensive care unit ; he also had osteo-articular localisation. All nine children have been treated with third-generation cephalosporins (C3G) and seven of them with quinolones. A newborn who only had cefotaxime and amoxicilline relapsed when the treatment stopped. He showed serious neurological complications and died at the age of eight months.

DISCUSSION

Salmonella meningitis are rare in France (our estimation is 0.2 % of all bacterial meningitis). They are more frequent in "emergent countries" (between 1 to 10 %). In such countries, there are important neurological complications and high relapse rates, often followed by death. Literature study and our observations show that the use of ciprofloxacine reduce the frequency of complications and risk of relapse.

CONCLUSIONS

The treatment currently advised for salmonella meningitis is to combine in first C3G with quinolone for at least three weeks. Risks of meningitis in case of digestive salmonellosis in infants urge discussion for preventive use of quinolones, particularly before the age of 6 months.

Authors+Show Affiliations

Service de pédiatrie, Centre Hospitalier Sud francilien, Evry, France. cecile.guillaumat@ch-sud-francilien.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

19268248

Citation

Guillaumat, C, et al. "[Salmonella Meningitis in Newborns and Infants. the Importance of Fluoroquinolones]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 15 Suppl 3, 2008, pp. S161-6.
Guillaumat C, Dang-Duy TL, Levy C, et al. [Salmonella meningitis in newborns and infants. The importance of fluoroquinolones]. Arch Pediatr. 2008;15 Suppl 3:S161-6.
Guillaumat, C., Dang-Duy, T. L., Levy, C., Cohen, R., & Leblanc, A. (2008). [Salmonella meningitis in newborns and infants. The importance of fluoroquinolones]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 15 Suppl 3, S161-6. https://doi.org/10.1016/S0929-693X(08)75501-5
Guillaumat C, et al. [Salmonella Meningitis in Newborns and Infants. the Importance of Fluoroquinolones]. Arch Pediatr. 2008;15 Suppl 3:S161-6. PubMed PMID: 19268248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Salmonella meningitis in newborns and infants. The importance of fluoroquinolones]. AU - Guillaumat,C, AU - Dang-Duy,T-L, AU - Levy,C, AU - Cohen,R, AU - Leblanc,A, AU - ,, PY - 2009/3/10/entrez PY - 2009/3/14/pubmed PY - 2009/4/28/medline SP - S161 EP - 6 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 15 Suppl 3 N2 - OBJECTIVES: To analyze the characteristics of the salmonella meningitis in new-borns and infants in France and sum up the complications and treatments. PATIENTS AND METHODS: The observations were taken from the national observatory of bacterial meningitis in children. The medical reports from paediatric and neo-natal departments have been analysed for each patient. RESULTS: The case reports concern 9 newborn babies and infants aged from twelve days to fifteen months (median 4 months). The initial clinical and biologic signs were not specific. Three children had had a digestive infection in the previous weeks, with a positive coproculture for salmonella in two of them. Two infants developed convulsions : 1 of them was hospitalized in intensive care unit ; he also had osteo-articular localisation. All nine children have been treated with third-generation cephalosporins (C3G) and seven of them with quinolones. A newborn who only had cefotaxime and amoxicilline relapsed when the treatment stopped. He showed serious neurological complications and died at the age of eight months. DISCUSSION: Salmonella meningitis are rare in France (our estimation is 0.2 % of all bacterial meningitis). They are more frequent in "emergent countries" (between 1 to 10 %). In such countries, there are important neurological complications and high relapse rates, often followed by death. Literature study and our observations show that the use of ciprofloxacine reduce the frequency of complications and risk of relapse. CONCLUSIONS: The treatment currently advised for salmonella meningitis is to combine in first C3G with quinolone for at least three weeks. Risks of meningitis in case of digestive salmonellosis in infants urge discussion for preventive use of quinolones, particularly before the age of 6 months. SN - 0929-693X UR - https://www.unboundmedicine.com/medline/citation/19268248/[Salmonella_meningitis_in_newborns_and_infants__The_importance_of_fluoroquinolones]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-693X(08)75501-5 DB - PRIME DP - Unbound Medicine ER -