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Omega-3 deficiency associated with perinatal depression: case control study.
Psychiatry Res. 2009 Apr 30; 166(2-3):254-9.PR

Abstract

Women are depleted of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the perinatal period due to fetal diversion. An association has been shown between lowered n-3 PUFAs and depression in general. We therefore hypothesise that women with lower n-3 PUFA levels are at greater risk of depression during pregnancy. Sixteen depressed and 22 non-depressed women were recruited during the third trimester and fasting bloods were taken for plasma fatty acid analysis. High docosahexaenoic acid (DHA), high total n-3 and a low n-6:n-3 ratio were associated with significantly lower odds of depression. After adjustment for parity, age and education level, those with high DHA still had significantly lower odds of being depressed. Those with high total n-3 and a low n-6:n-3 ratio were also at significantly reduced risk of depression, although the magnitude of the difference was reduced. Study results quantified women with lower omega-3 PUFA levels as being six times more likely to be depressed antenatally, compared to women who had higher omega-3 PUFA levels. The prophylactic benefits of supplementation either prenatally or during pregnancy require close study to assess whether omega-3 PUFAs play a role in the prevention of perinatal depression.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, The Black Dog Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia. a.rees@unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19268372

Citation

Rees, Anne-Marie, et al. "Omega-3 Deficiency Associated With Perinatal Depression: Case Control Study." Psychiatry Research, vol. 166, no. 2-3, 2009, pp. 254-9.
Rees AM, Austin MP, Owen C, et al. Omega-3 deficiency associated with perinatal depression: case control study. Psychiatry Res. 2009;166(2-3):254-9.
Rees, A. M., Austin, M. P., Owen, C., & Parker, G. (2009). Omega-3 deficiency associated with perinatal depression: case control study. Psychiatry Research, 166(2-3), 254-9. https://doi.org/10.1016/j.psychres.2007.12.011
Rees AM, et al. Omega-3 Deficiency Associated With Perinatal Depression: Case Control Study. Psychiatry Res. 2009 Apr 30;166(2-3):254-9. PubMed PMID: 19268372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 deficiency associated with perinatal depression: case control study. AU - Rees,Anne-Marie, AU - Austin,Marie-Paule, AU - Owen,Catherine, AU - Parker,Gordon, Y1 - 2009/03/05/ PY - 2007/03/26/received PY - 2007/07/16/revised PY - 2007/12/18/accepted PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2009/7/2/medline SP - 254 EP - 9 JF - Psychiatry research JO - Psychiatry Res VL - 166 IS - 2-3 N2 - Women are depleted of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the perinatal period due to fetal diversion. An association has been shown between lowered n-3 PUFAs and depression in general. We therefore hypothesise that women with lower n-3 PUFA levels are at greater risk of depression during pregnancy. Sixteen depressed and 22 non-depressed women were recruited during the third trimester and fasting bloods were taken for plasma fatty acid analysis. High docosahexaenoic acid (DHA), high total n-3 and a low n-6:n-3 ratio were associated with significantly lower odds of depression. After adjustment for parity, age and education level, those with high DHA still had significantly lower odds of being depressed. Those with high total n-3 and a low n-6:n-3 ratio were also at significantly reduced risk of depression, although the magnitude of the difference was reduced. Study results quantified women with lower omega-3 PUFA levels as being six times more likely to be depressed antenatally, compared to women who had higher omega-3 PUFA levels. The prophylactic benefits of supplementation either prenatally or during pregnancy require close study to assess whether omega-3 PUFAs play a role in the prevention of perinatal depression. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/19268372/Omega_3_deficiency_associated_with_perinatal_depression:_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(07)00439-8 DB - PRIME DP - Unbound Medicine ER -