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Primary peripheral primitive neuroectodermal tumor/Ewing's tumor of the testis in a 46-year-old man-differential diagnosis and review of the literature.
Hum Pathol. 2009 Jun; 40(6):893-7.HP

Abstract

Peripheral primitive neuroectodermal tumor/Ewing's tumors are rare bone and soft tissue malignancies with a highly aggressive clinical course and early metastases occurring at multiple peripheral sites. Here, we present for the first time a case of a 46-year-old man with a primary peripheral primitive neuroectodermal tumor/Ewing's tumor of the testis. The diagnosis of peripheral primitive neuroectodermal tumor/Ewing's tumor was established by histology, immunohistochemistry, and molecular pathology. The tumor revealed a rapid progress in 2 months' time. Therefore, the patient was included in the EURO-E.W.I.N.G.99 study and was placed on chemotherapy. However, the tumor progressed during ongoing therapy, and the patient died in March 2008. In conclusion, though being reported here for the first time, peripheral primitive neuroectodermal tumor/Ewing's tumors should be considered in the differential diagnosis of blue round cell tumors of the testis. A rapid and correct diagnosis of this entity is crucial for fast and accurate therapy, which is stressed by the fatal case presented here.

Authors+Show Affiliations

Institute of Pathology, Heinrich-Heine University Hospital, Duesseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19269015

Citation

Heikaus, Sebastian, et al. "Primary Peripheral Primitive Neuroectodermal tumor/Ewing's Tumor of the Testis in a 46-year-old Man-differential Diagnosis and Review of the Literature." Human Pathology, vol. 40, no. 6, 2009, pp. 893-7.
Heikaus S, Schaefer KL, Eucker J, et al. Primary peripheral primitive neuroectodermal tumor/Ewing's tumor of the testis in a 46-year-old man-differential diagnosis and review of the literature. Hum Pathol. 2009;40(6):893-7.
Heikaus, S., Schaefer, K. L., Eucker, J., Hogrebe, E., Danebrock, R., Wai, D. H., Krenn, V., Gabbert, H. E., & Poremba, C. (2009). Primary peripheral primitive neuroectodermal tumor/Ewing's tumor of the testis in a 46-year-old man-differential diagnosis and review of the literature. Human Pathology, 40(6), 893-7. https://doi.org/10.1016/j.humpath.2008.11.009
Heikaus S, et al. Primary Peripheral Primitive Neuroectodermal tumor/Ewing's Tumor of the Testis in a 46-year-old Man-differential Diagnosis and Review of the Literature. Hum Pathol. 2009;40(6):893-7. PubMed PMID: 19269015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary peripheral primitive neuroectodermal tumor/Ewing's tumor of the testis in a 46-year-old man-differential diagnosis and review of the literature. AU - Heikaus,Sebastian, AU - Schaefer,Karl-Ludwig, AU - Eucker,Jan, AU - Hogrebe,Esther, AU - Danebrock,Raihanatou, AU - Wai,Daniel H, AU - Krenn,Veit, AU - Gabbert,Helmut E, AU - Poremba,Christopher, Y1 - 2009/03/09/ PY - 2008/07/08/received PY - 2008/11/07/revised PY - 2008/11/10/accepted PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2009/6/9/medline SP - 893 EP - 7 JF - Human pathology JO - Hum. Pathol. VL - 40 IS - 6 N2 - Peripheral primitive neuroectodermal tumor/Ewing's tumors are rare bone and soft tissue malignancies with a highly aggressive clinical course and early metastases occurring at multiple peripheral sites. Here, we present for the first time a case of a 46-year-old man with a primary peripheral primitive neuroectodermal tumor/Ewing's tumor of the testis. The diagnosis of peripheral primitive neuroectodermal tumor/Ewing's tumor was established by histology, immunohistochemistry, and molecular pathology. The tumor revealed a rapid progress in 2 months' time. Therefore, the patient was included in the EURO-E.W.I.N.G.99 study and was placed on chemotherapy. However, the tumor progressed during ongoing therapy, and the patient died in March 2008. In conclusion, though being reported here for the first time, peripheral primitive neuroectodermal tumor/Ewing's tumors should be considered in the differential diagnosis of blue round cell tumors of the testis. A rapid and correct diagnosis of this entity is crucial for fast and accurate therapy, which is stressed by the fatal case presented here. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/19269015/Primary_peripheral_primitive_neuroectodermal_tumor/Ewing's_tumor_of_the_testis_in_a_46_year_old_man_differential_diagnosis_and_review_of_the_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(08)00567-4 DB - PRIME DP - Unbound Medicine ER -