Tags

Type your tag names separated by a space and hit enter

Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus.
J Diabetes Complications. 2010 Mar-Apr; 24(2):109-14.JD

Abstract

Fifty-six pregnant women with gestational diabetes mellitus (GDM) and 42 normal glucose tolerant (NGT) pregnant women between 26 and 36 gestational weeks were included in the study prospectively. The body fat percentage (BFP) was calculated using the Siri formula from skinfold thickness (SFT) measurements. Both groups were comparable for gestational age, height, weight, and body mass index (P>.05). Insulin resistance assessed by homeostasis model assessment for insulin resistance (HOMA-IR) method was significantly higher in GDM patients compared to their NGT weight-matched control group. In contrast, the insulin sensitivity calculated from quantitative insulin sensitivity check index (QUICKI-IS) equation was significantly lower in GDM group. Calculated lean body mass was found to be similar in between both groups. Body fat percentage derived from SFT parameters was significantly higher in women with GDM. Women with GDM had significantly higher levels of serum insulin and leptin concentrations when compared with the NGT group. All SFT measurements were higher in GDM group when compared to those in NGT women. We did not find any correlation between leptin levels and insulin resistance; we found negative correlation between leptin levels and insulin sensitivity. Thus, we observed that leptin may contribute development of GDM by decreasing insulin sensitivity but not increasing insulin resistance. Also, we observed that the BFP estimated by the Siri formula from SFT measurements correlated significantly with HOMA-IR and QUICKI-IS and leptin concentrations in pregnant women. We suggest that by simply evaluating SFT, we may hold a view about BFP and leptin concentrations and insulin sensitivity in pregnant women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Diyarbakir Military Hospital, Diyarbakir, Turkey. ozgur_md@yahoo.com <ozgur_md@yahoo.com>No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19269197

Citation

Yilmaz, Ozgur, et al. "Assessment of Insulin Sensitivity/resistance and Their Relations With Leptin Concentrations and Anthropometric Measures in a Pregnant Population With and Without Gestational Diabetes Mellitus." Journal of Diabetes and Its Complications, vol. 24, no. 2, 2010, pp. 109-14.
Yilmaz O, Kucuk M, Ilgin A, et al. Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. J Diabetes Complicat. 2010;24(2):109-14.
Yilmaz, O., Kucuk, M., Ilgin, A., & Dagdelen, M. (2010). Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. Journal of Diabetes and Its Complications, 24(2), 109-14. https://doi.org/10.1016/j.jdiacomp.2009.01.006
Yilmaz O, et al. Assessment of Insulin Sensitivity/resistance and Their Relations With Leptin Concentrations and Anthropometric Measures in a Pregnant Population With and Without Gestational Diabetes Mellitus. J Diabetes Complicat. 2010;24(2):109-14. PubMed PMID: 19269197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. AU - Yilmaz,Ozgur, AU - Kucuk,Mert, AU - Ilgin,Aydin, AU - Dagdelen,Muride, Y1 - 2009/03/06/ PY - 2008/05/25/received PY - 2008/12/15/revised PY - 2009/01/21/accepted PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2010/6/15/medline SP - 109 EP - 14 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 24 IS - 2 N2 - Fifty-six pregnant women with gestational diabetes mellitus (GDM) and 42 normal glucose tolerant (NGT) pregnant women between 26 and 36 gestational weeks were included in the study prospectively. The body fat percentage (BFP) was calculated using the Siri formula from skinfold thickness (SFT) measurements. Both groups were comparable for gestational age, height, weight, and body mass index (P>.05). Insulin resistance assessed by homeostasis model assessment for insulin resistance (HOMA-IR) method was significantly higher in GDM patients compared to their NGT weight-matched control group. In contrast, the insulin sensitivity calculated from quantitative insulin sensitivity check index (QUICKI-IS) equation was significantly lower in GDM group. Calculated lean body mass was found to be similar in between both groups. Body fat percentage derived from SFT parameters was significantly higher in women with GDM. Women with GDM had significantly higher levels of serum insulin and leptin concentrations when compared with the NGT group. All SFT measurements were higher in GDM group when compared to those in NGT women. We did not find any correlation between leptin levels and insulin resistance; we found negative correlation between leptin levels and insulin sensitivity. Thus, we observed that leptin may contribute development of GDM by decreasing insulin sensitivity but not increasing insulin resistance. Also, we observed that the BFP estimated by the Siri formula from SFT measurements correlated significantly with HOMA-IR and QUICKI-IS and leptin concentrations in pregnant women. We suggest that by simply evaluating SFT, we may hold a view about BFP and leptin concentrations and insulin sensitivity in pregnant women. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/19269197/Assessment_of_insulin_sensitivity/resistance_and_their_relations_with_leptin_concentrations_and_anthropometric_measures_in_a_pregnant_population_with_and_without_gestational_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(09)00006-3 DB - PRIME DP - Unbound Medicine ER -