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Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode.
Talanta. 2009 May 15; 78(3):748-52.T

Abstract

A simple and highly selective electrochemical method was developed for the single or simultaneous determination of paracetamol (N-acetyl-p-aminophenol, acetaminophen) and caffeine (3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione) in aqueous media (acetate buffer, pH 4.5) on a boron-doped diamond (BDD) electrode using square wave voltammetry (SWV) or differential pulse voltammetry (DPV). Using DPV with the cathodically pre-treated BDD electrode, a separation of about 550 mV between the peak oxidation potentials of paracetamol and caffeine present in binary mixtures was obtained. The calibration curves for the simultaneous determination of paracetamol and caffeine showed an excellent linear response, ranging from 5.0 x 10(-7)mol L(-1) to 8.3 x 10(-5)mol L(-1) for both compounds. The detection limits for the simultaneous determination of paracetamol and caffeine were 4.9 x 10(-7)mol L(-1) and 3.5 x 10(-8)mol L(-1), respectively. The proposed method was successfully applied in the simultaneous determination of paracetamol and caffeine in several pharmaceutical formulations (tablets), with results similar to those obtained using a high-performance liquid chromatography method (at 95% confidence level).

Authors+Show Affiliations

Instituto de Química de São Carlos, Universidade de São Paulo, C.P. 780, 13560-970 São Carlos, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19269423

Citation

Lourenção, Bruna Cláudia, et al. "Simultaneous Voltammetric Determination of Paracetamol and Caffeine in Pharmaceutical Formulations Using a Boron-doped Diamond Electrode." Talanta, vol. 78, no. 3, 2009, pp. 748-52.
Lourenção BC, Medeiros RA, Rocha-Filho RC, et al. Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode. Talanta. 2009;78(3):748-52.
Lourenção, B. C., Medeiros, R. A., Rocha-Filho, R. C., Mazo, L. H., & Fatibello-Filho, O. (2009). Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode. Talanta, 78(3), 748-52. https://doi.org/10.1016/j.talanta.2008.12.040
Lourenção BC, et al. Simultaneous Voltammetric Determination of Paracetamol and Caffeine in Pharmaceutical Formulations Using a Boron-doped Diamond Electrode. Talanta. 2009 May 15;78(3):748-52. PubMed PMID: 19269423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode. AU - Lourenção,Bruna Cláudia, AU - Medeiros,Roberta Antigo, AU - Rocha-Filho,Romeu C, AU - Mazo,Luiz Henrique, AU - Fatibello-Filho,Orlando, Y1 - 2008/12/30/ PY - 2008/10/20/received PY - 2008/12/15/revised PY - 2008/12/16/accepted PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2009/4/30/medline SP - 748 EP - 52 JF - Talanta JO - Talanta VL - 78 IS - 3 N2 - A simple and highly selective electrochemical method was developed for the single or simultaneous determination of paracetamol (N-acetyl-p-aminophenol, acetaminophen) and caffeine (3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione) in aqueous media (acetate buffer, pH 4.5) on a boron-doped diamond (BDD) electrode using square wave voltammetry (SWV) or differential pulse voltammetry (DPV). Using DPV with the cathodically pre-treated BDD electrode, a separation of about 550 mV between the peak oxidation potentials of paracetamol and caffeine present in binary mixtures was obtained. The calibration curves for the simultaneous determination of paracetamol and caffeine showed an excellent linear response, ranging from 5.0 x 10(-7)mol L(-1) to 8.3 x 10(-5)mol L(-1) for both compounds. The detection limits for the simultaneous determination of paracetamol and caffeine were 4.9 x 10(-7)mol L(-1) and 3.5 x 10(-8)mol L(-1), respectively. The proposed method was successfully applied in the simultaneous determination of paracetamol and caffeine in several pharmaceutical formulations (tablets), with results similar to those obtained using a high-performance liquid chromatography method (at 95% confidence level). SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/19269423/Simultaneous_voltammetric_determination_of_paracetamol_and_caffeine_in_pharmaceutical_formulations_using_a_boron_doped_diamond_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(08)00924-7 DB - PRIME DP - Unbound Medicine ER -