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Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats.
J Korean Med Sci. 2009 Feb; 24(1):146-51.JK

Abstract

This study was designed to determine whether early gabapentin treatment has a protective analgesic effect on neuropathic pain and compared its effect to the late treatment in a rat neuropathic model, and as the potential mechanism of protective action, the alpha(2)delta(1)-subunit of the voltage-dependent calcium channel (alpha(2)delta(1)-subunit) was evaluated in both sides of the L5 dorsal root ganglia (DRG). Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve. For the early treatment group, rats were injected with gabapentin (100 mg/kg) intraperitoneally 15 min prior to surgery and then every 24 hr during postoperative day (POD) 1-4. For the late treatment group, the same dose of gabapentin was injected every 24 hr during POD 8-12. For the control group, L5 nerve was ligated but no gabapentin was administered. In the early treatment group, the development of allodynia was delayed up to POD 10, whereas allodynia was developed on POD 2 in the control and the late treatment group (p<0.05). The alpha(2)delta(1)-subunit was up-regulated in all groups, however, there was no difference in the level of the alpha(2)delta(1)-subunit among the three groups. These results suggest that early treatment with gabapentin offers some protection against neuropathic pain but it is unlikely that this action is mediated through modulation of the alpha(2)delta(1)-subunit in DRG.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19270828

Citation

Hahm, Tae Soo, et al. "Protective Effects of Gabapentin On Allodynia and Alpha 2 Delta 1-subunit of Voltage-dependent Calcium Channel in Spinal Nerve-ligated Rats." Journal of Korean Medical Science, vol. 24, no. 1, 2009, pp. 146-51.
Hahm TS, Ahn HJ, Bae CD, et al. Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats. J Korean Med Sci. 2009;24(1):146-51.
Hahm, T. S., Ahn, H. J., Bae, C. D., Kim, H. S., Lim, S. W., Cho, H. S., Lee, S. M., Sim, W. S., Kim, J. A., Gwak, M. S., & Choi, S. J. (2009). Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats. Journal of Korean Medical Science, 24(1), 146-51. https://doi.org/10.3346/jkms.2009.24.1.146
Hahm TS, et al. Protective Effects of Gabapentin On Allodynia and Alpha 2 Delta 1-subunit of Voltage-dependent Calcium Channel in Spinal Nerve-ligated Rats. J Korean Med Sci. 2009;24(1):146-51. PubMed PMID: 19270828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats. AU - Hahm,Tae Soo, AU - Ahn,Hyun Joo, AU - Bae,Chang-Dae, AU - Kim,Han-Seop, AU - Lim,Seung Woon, AU - Cho,Hyun Sung, AU - Lee,Sangmin M, AU - Sim,Woo Seog, AU - Kim,Jie Ae, AU - Gwak,Mi Sook, AU - Choi,Soo Joo, Y1 - 2009/02/28/ PY - 2008/01/25/received PY - 2008/05/08/accepted PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2009/5/21/medline KW - Alpha 2 Delta-1 Subunit KW - Calcium Channels KW - Gabapentin KW - Neuropathic Pain KW - Protective SP - 146 EP - 51 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 24 IS - 1 N2 - This study was designed to determine whether early gabapentin treatment has a protective analgesic effect on neuropathic pain and compared its effect to the late treatment in a rat neuropathic model, and as the potential mechanism of protective action, the alpha(2)delta(1)-subunit of the voltage-dependent calcium channel (alpha(2)delta(1)-subunit) was evaluated in both sides of the L5 dorsal root ganglia (DRG). Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve. For the early treatment group, rats were injected with gabapentin (100 mg/kg) intraperitoneally 15 min prior to surgery and then every 24 hr during postoperative day (POD) 1-4. For the late treatment group, the same dose of gabapentin was injected every 24 hr during POD 8-12. For the control group, L5 nerve was ligated but no gabapentin was administered. In the early treatment group, the development of allodynia was delayed up to POD 10, whereas allodynia was developed on POD 2 in the control and the late treatment group (p<0.05). The alpha(2)delta(1)-subunit was up-regulated in all groups, however, there was no difference in the level of the alpha(2)delta(1)-subunit among the three groups. These results suggest that early treatment with gabapentin offers some protection against neuropathic pain but it is unlikely that this action is mediated through modulation of the alpha(2)delta(1)-subunit in DRG. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/19270828/Protective_effects_of_gabapentin_on_allodynia_and_alpha_2_delta_1_subunit_of_voltage_dependent_calcium_channel_in_spinal_nerve_ligated_rats_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2009.24.1.146 DB - PRIME DP - Unbound Medicine ER -