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Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia.
Arch Gynecol Obstet. 2009 Nov; 280(5):793-7.AG

Abstract

OBJECTIVE

To evaluate the maternal and fetal outcome in pregnant women with sickle cell disease and to highlight the complications encountered during pregnancy and delivery at a university hospital in the Eastern Saudi Arabia.

STUDY DESIGN

A retrospective study of 255 pregnancies in 145 patients with sickle cell disease (SCD) over an 8-year-period analyzed the perinatal complications and maternal and fetal outcomes compared with a control group of 500 Saudi females with the normal hemoglobin phenotype selected randomly that matched for age, parity and delivered during the study period.

RESULTS

The incidence of SCD was 1.3% of all deliveries with one maternal death (0.4%) and a perinatal mortality rate of 78.2/1,000 deliveries in the series. The major maternal complications in the 255 pregnancies were anemia 84.3%, sickle cell crisis 44.3% (26.6% painful and 17.7% hemolytic crises), infection 45.9%, fetal growth restriction 20.1%, preterm delivery 12.6%, and pregnancy-induced hypertension 10.6%. Blood transfusion was necessary in 34% pregnancies. Stillbirths accounted for 63% of the perinatal mortality.

CONCLUSIONS

Saudi women with SCD are at a greater risk of morbidity and mortality in pregnancy than previously reported, with a high perinatal mortality rate. Early booking, meticulous antenatal care and supervised hospital delivery will improve the maternal and fetal outcomes in these patients.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, College of Medicine, King Faisal University, Dammam, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19271230

Citation

Al Jama, Fathia E., et al. "Pregnancy Outcome in Patients With Homozygous Sickle Cell Disease in a University Hospital, Eastern Saudi Arabia." Archives of Gynecology and Obstetrics, vol. 280, no. 5, 2009, pp. 793-7.
Al Jama FE, Gasem T, Burshaid S, et al. Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia. Arch Gynecol Obstet. 2009;280(5):793-7.
Al Jama, F. E., Gasem, T., Burshaid, S., Rahman, J., Al Suleiman, S. A., & Rahman, M. S. (2009). Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia. Archives of Gynecology and Obstetrics, 280(5), 793-7. https://doi.org/10.1007/s00404-009-1002-7
Al Jama FE, et al. Pregnancy Outcome in Patients With Homozygous Sickle Cell Disease in a University Hospital, Eastern Saudi Arabia. Arch Gynecol Obstet. 2009;280(5):793-7. PubMed PMID: 19271230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia. AU - Al Jama,Fathia E, AU - Gasem,Turki, AU - Burshaid,Sameera, AU - Rahman,Jessica, AU - Al Suleiman,Suleiman A, AU - Rahman,Mohammad Sayedur, Y1 - 2009/03/07/ PY - 2009/01/02/received PY - 2009/02/10/accepted PY - 2009/3/10/entrez PY - 2009/3/10/pubmed PY - 2010/1/29/medline SP - 793 EP - 7 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 280 IS - 5 N2 - OBJECTIVE: To evaluate the maternal and fetal outcome in pregnant women with sickle cell disease and to highlight the complications encountered during pregnancy and delivery at a university hospital in the Eastern Saudi Arabia. STUDY DESIGN: A retrospective study of 255 pregnancies in 145 patients with sickle cell disease (SCD) over an 8-year-period analyzed the perinatal complications and maternal and fetal outcomes compared with a control group of 500 Saudi females with the normal hemoglobin phenotype selected randomly that matched for age, parity and delivered during the study period. RESULTS: The incidence of SCD was 1.3% of all deliveries with one maternal death (0.4%) and a perinatal mortality rate of 78.2/1,000 deliveries in the series. The major maternal complications in the 255 pregnancies were anemia 84.3%, sickle cell crisis 44.3% (26.6% painful and 17.7% hemolytic crises), infection 45.9%, fetal growth restriction 20.1%, preterm delivery 12.6%, and pregnancy-induced hypertension 10.6%. Blood transfusion was necessary in 34% pregnancies. Stillbirths accounted for 63% of the perinatal mortality. CONCLUSIONS: Saudi women with SCD are at a greater risk of morbidity and mortality in pregnancy than previously reported, with a high perinatal mortality rate. Early booking, meticulous antenatal care and supervised hospital delivery will improve the maternal and fetal outcomes in these patients. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/19271230/Pregnancy_outcome_in_patients_with_homozygous_sickle_cell_disease_in_a_university_hospital_Eastern_Saudi_Arabia_ DB - PRIME DP - Unbound Medicine ER -