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Flavonoid glucosides from the hairy roots of Catharanthus roseus.
J Nat Prod. 2009 Apr; 72(4):613-20.JN

Abstract

Four new flavonoid glucosides, 3',4'-di-O-methylquercetin-7-O-[(4''-->13''')-2''',6''',10''',14'''-tetramethylhexadec-13'''-ol-14'''-enyl]-beta-D-glucopyranoside (1), 4'-O-methylkaempferol-3-O-[(4''-->13''')- 2''',6''',10''',14'''-tetramethylhexadecan-13'''-olyl]-beta-D-glucopyranoside (2), 3',4'-di-O-methylbutin-7-O-[(6''-->1''')-3''',11'''-dimethyl-7'''-methylenedodeca-3''',10'''-dienyl]-beta-D-glucopyranoside (3), and 4'-O-methylbutin-7-O-[(6''-->1''')-3''',11'''-dimethyl-7'''-hydroxymethylenedodecanyl]-beta-D-glucopyranoside (4), along with the three known compounds were isolated from the methanol extract of Catharanthus roseus hairy roots. Their structures were elucidated spectroscopically. The new flavonoid glucosides inhibited both MMP-9 activity and TNF-alpha production in THP-1 cells treated with lipopolysaccharide.

Authors+Show Affiliations

Department of Applied Life Science, Konkuk University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19271765

Citation

Chung, Ill-Min, et al. "Flavonoid Glucosides From the Hairy Roots of Catharanthus Roseus." Journal of Natural Products, vol. 72, no. 4, 2009, pp. 613-20.
Chung IM, Ahmad A, Ali M, et al. Flavonoid glucosides from the hairy roots of Catharanthus roseus. J Nat Prod. 2009;72(4):613-20.
Chung, I. M., Ahmad, A., Ali, M., Lee, O. K., Kim, M. Y., Kim, J. H., Yoon, D. Y., Peebles, C. A., & San, K. Y. (2009). Flavonoid glucosides from the hairy roots of Catharanthus roseus. Journal of Natural Products, 72(4), 613-20. https://doi.org/10.1021/np800378q
Chung IM, et al. Flavonoid Glucosides From the Hairy Roots of Catharanthus Roseus. J Nat Prod. 2009;72(4):613-20. PubMed PMID: 19271765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoid glucosides from the hairy roots of Catharanthus roseus. AU - Chung,Ill-Min, AU - Ahmad,Ateeque, AU - Ali,Mohd, AU - Lee,Oh-Kyu, AU - Kim,Min-Young, AU - Kim,Jung-Hee, AU - Yoon,Do-Young, AU - Peebles,Christie A M, AU - San,Ka Yiu, PY - 2009/3/11/entrez PY - 2009/3/11/pubmed PY - 2009/5/21/medline SP - 613 EP - 20 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 4 N2 - Four new flavonoid glucosides, 3',4'-di-O-methylquercetin-7-O-[(4''-->13''')-2''',6''',10''',14'''-tetramethylhexadec-13'''-ol-14'''-enyl]-beta-D-glucopyranoside (1), 4'-O-methylkaempferol-3-O-[(4''-->13''')- 2''',6''',10''',14'''-tetramethylhexadecan-13'''-olyl]-beta-D-glucopyranoside (2), 3',4'-di-O-methylbutin-7-O-[(6''-->1''')-3''',11'''-dimethyl-7'''-methylenedodeca-3''',10'''-dienyl]-beta-D-glucopyranoside (3), and 4'-O-methylbutin-7-O-[(6''-->1''')-3''',11'''-dimethyl-7'''-hydroxymethylenedodecanyl]-beta-D-glucopyranoside (4), along with the three known compounds were isolated from the methanol extract of Catharanthus roseus hairy roots. Their structures were elucidated spectroscopically. The new flavonoid glucosides inhibited both MMP-9 activity and TNF-alpha production in THP-1 cells treated with lipopolysaccharide. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19271765/Flavonoid_glucosides_from_the_hairy_roots_of_Catharanthus_roseus_ DB - PRIME DP - Unbound Medicine ER -