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Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study.
World J Surg Oncol. 2009 Mar 09; 7:27.WJ

Abstract

BACKGROUND

Mucin immunoexpression in adenocarcinoma arising in Barrett's esophagus (BE) may indicate the carcinogenesis pathway. The aim of this study was to evaluate resected specimens of adenocarcinoma in BE for the pattern of mucins and to correlate to the histologic classification.

METHODS

Specimens were retrospectively collected from thirteen patients who underwent esophageal resection due to adenocarcinoma in BE. Sections were scored for the grade of intestinal metaplasia. The tissues were examined by immunohistochemistry for MUC2 and MUC5AC antibodies.

RESULTS

Eleven patients were men. The mean age was 61 years old (varied from 40 to 75 years old). The tumor size had a mean of 4.7 +/- 2.3 cm, and the extension of BE had a mean of 7.7 +/- 1.5 cm. Specialized epithelium with intestinal metaplasia was present in all adjacent mucosas. Immunohistochemistry for MUC2 showed immunoreactivity in goblet cells, while MUC5AC was extensively expressed in the columnar gastric cells, localizing to the surface epithelium and extending to a variable degree into the glandular structures in BE. Tumors were classified according to the mucins in gastric type in 7/13 (MUC5AC positive) and intestinal type in 4/13 (MUC2 positive). Two tumors did not express MUC2 or MUC5AC proteins. The pattern of mucin predominantly expressed in the adjacent epithelium was associated to the mucin expression profile in the tumors, p = 0.047.

CONCLUSION

Barrett's esophagus adenocarcinoma shows either gastric or intestinal type pattern of mucin expression. The two types of tumors developed in Barrett's esophagus may reflect the original cell type involved in the malignant transformation.

Authors+Show Affiliations

Department of Gastroenterology, Digestive Surgery Division, University of São Paulo School of Medicine, São Paulo, Brazil. sergioszac@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19272137

Citation

Szachnowicz, Sergio, et al. "Mucin Pattern Reflects the Origin of the Adenocarcinoma in Barrett's Esophagus: a Retrospective Clinical and Laboratorial Study." World Journal of Surgical Oncology, vol. 7, 2009, p. 27.
Szachnowicz S, Cecconello I, Ribeiro U, et al. Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study. World J Surg Oncol. 2009;7:27.
Szachnowicz, S., Cecconello, I., Ribeiro, U., Iriya, K., El Ibrahim, R., Takeda, F. R., Corbett, C. E., & Vaz Safatle-Ribeiro, A. (2009). Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study. World Journal of Surgical Oncology, 7, 27. https://doi.org/10.1186/1477-7819-7-27
Szachnowicz S, et al. Mucin Pattern Reflects the Origin of the Adenocarcinoma in Barrett's Esophagus: a Retrospective Clinical and Laboratorial Study. World J Surg Oncol. 2009 Mar 9;7:27. PubMed PMID: 19272137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study. AU - Szachnowicz,Sergio, AU - Cecconello,Ivan, AU - Ribeiro,Ulysses, AU - Iriya,Kiyoshi, AU - El Ibrahim,Roberto, AU - Takeda,Flávio Roberto, AU - Corbett,Carlos Eduardo Pereira, AU - Vaz Safatle-Ribeiro,Adriana, Y1 - 2009/03/09/ PY - 2008/11/13/received PY - 2009/03/09/accepted PY - 2009/3/11/entrez PY - 2009/3/11/pubmed PY - 2009/7/16/medline SP - 27 EP - 27 JF - World journal of surgical oncology JO - World J Surg Oncol VL - 7 N2 - BACKGROUND: Mucin immunoexpression in adenocarcinoma arising in Barrett's esophagus (BE) may indicate the carcinogenesis pathway. The aim of this study was to evaluate resected specimens of adenocarcinoma in BE for the pattern of mucins and to correlate to the histologic classification. METHODS: Specimens were retrospectively collected from thirteen patients who underwent esophageal resection due to adenocarcinoma in BE. Sections were scored for the grade of intestinal metaplasia. The tissues were examined by immunohistochemistry for MUC2 and MUC5AC antibodies. RESULTS: Eleven patients were men. The mean age was 61 years old (varied from 40 to 75 years old). The tumor size had a mean of 4.7 +/- 2.3 cm, and the extension of BE had a mean of 7.7 +/- 1.5 cm. Specialized epithelium with intestinal metaplasia was present in all adjacent mucosas. Immunohistochemistry for MUC2 showed immunoreactivity in goblet cells, while MUC5AC was extensively expressed in the columnar gastric cells, localizing to the surface epithelium and extending to a variable degree into the glandular structures in BE. Tumors were classified according to the mucins in gastric type in 7/13 (MUC5AC positive) and intestinal type in 4/13 (MUC2 positive). Two tumors did not express MUC2 or MUC5AC proteins. The pattern of mucin predominantly expressed in the adjacent epithelium was associated to the mucin expression profile in the tumors, p = 0.047. CONCLUSION: Barrett's esophagus adenocarcinoma shows either gastric or intestinal type pattern of mucin expression. The two types of tumors developed in Barrett's esophagus may reflect the original cell type involved in the malignant transformation. SN - 1477-7819 UR - https://www.unboundmedicine.com/medline/citation/19272137/Mucin_pattern_reflects_the_origin_of_the_adenocarcinoma_in_Barrett's_esophagus:_a_retrospective_clinical_and_laboratorial_study_ L2 - https://wjso.biomedcentral.com/articles/10.1186/1477-7819-7-27 DB - PRIME DP - Unbound Medicine ER -