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[Experimental study on therapeutic efficacy of tetrandrine on lung injury induced by acute of paraquat poisoning].

Abstract

OBJECTIVE

To investigate the antagonistic efficacy of tetrandrine (TET) on lung injury induced by acute paraquat poisoning.

METHODS

Male Wistar rats were randomly divided into three groups (control group, non-treatment group and treatment group). The tetrandrine of 30 mg/kg was given by gastric lavage six hours after 32 rats were intraperitoneally injected with paraquat 15 mg/kg (treatment group). Then the same dose of tetrandrine was given once a day. Normal saline of the same volume was given by gastric lavage in another 32 rats intraperitoneally injected with paraquat 15 mg/kg (non-treatment group). Seven rats were intraperitoneally injected by normal saline as the control group. Levels of maleic dialdehyde (MDA), activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in plasma and the lung homogenate of three groups were determined at 3 d, 7 d, 14 d and 21 d after exposure to paraquat. Histological changes of the lungs were observed.

RESULTS

The levels of MDA at 3 d both in plasma [(3.65 +/- 0.44) nmol/ml] and the lung homogenate [(9.54 +/- 0.92) nmol/mg pro] of the non-treatment group significantly increased compared with the control group (P < 0.01), the activities of GSH-Px and SOD in plasma at 3 d were significantly less than the control group (P < 0.05 or P < 0.01), the activities of GSH-Px (3 d, 7 d) and SOD (7 d, 14 d) in the lung homogenate were significantly less than the control group (P < 0.05). There were no significant difference in the levels of MDA both in plasma and the lung homogenate between the treatment group and the non-treatment group (P > 0.05). The SOD activities of treatment group on the third day was significantly increased compared with the non-treatment group (P < 0.01 or P < 0.05). Although the activities of GSH-Px in plasma and the lung homogenate of the treatment group on the third day were increased, there was no significantly difference compared with the non-treatment group (P > 0.05). The integral score of pulmonary fibrosis in the treatment group were significantly lower than in the non-treatment group (P < 0.01).

CONCLUSION

TET has antagonistic effect against acute toxicity of paraquat through significant reduction of pulmonary fibrosis.

Authors+Show Affiliations

National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19272249

Citation

Zhu, Qiu-Hong, et al. "[Experimental Study On Therapeutic Efficacy of Tetrandrine On Lung Injury Induced By Acute of Paraquat Poisoning]." Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases, vol. 26, no. 10, 2008, pp. 583-7.
Zhu QH, Huang JX, Meng CS, et al. [Experimental study on therapeutic efficacy of tetrandrine on lung injury induced by acute of paraquat poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008;26(10):583-7.
Zhu, Q. H., Huang, J. X., Meng, C. S., Wang, M. L., Chen, W., & Zhang, X. (2008). [Experimental study on therapeutic efficacy of tetrandrine on lung injury induced by acute of paraquat poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases, 26(10), 583-7.
Zhu QH, et al. [Experimental Study On Therapeutic Efficacy of Tetrandrine On Lung Injury Induced By Acute of Paraquat Poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008;26(10):583-7. PubMed PMID: 19272249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Experimental study on therapeutic efficacy of tetrandrine on lung injury induced by acute of paraquat poisoning]. AU - Zhu,Qiu-Hong, AU - Huang,Jin-Xiang, AU - Meng,Cong-Shen, AU - Wang,Ming-Liang, AU - Chen,Wei, AU - Zhang,Xing, PY - 2009/3/11/entrez PY - 2009/3/11/pubmed PY - 2012/3/2/medline SP - 583 EP - 7 JF - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases JO - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi VL - 26 IS - 10 N2 - OBJECTIVE: To investigate the antagonistic efficacy of tetrandrine (TET) on lung injury induced by acute paraquat poisoning. METHODS: Male Wistar rats were randomly divided into three groups (control group, non-treatment group and treatment group). The tetrandrine of 30 mg/kg was given by gastric lavage six hours after 32 rats were intraperitoneally injected with paraquat 15 mg/kg (treatment group). Then the same dose of tetrandrine was given once a day. Normal saline of the same volume was given by gastric lavage in another 32 rats intraperitoneally injected with paraquat 15 mg/kg (non-treatment group). Seven rats were intraperitoneally injected by normal saline as the control group. Levels of maleic dialdehyde (MDA), activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in plasma and the lung homogenate of three groups were determined at 3 d, 7 d, 14 d and 21 d after exposure to paraquat. Histological changes of the lungs were observed. RESULTS: The levels of MDA at 3 d both in plasma [(3.65 +/- 0.44) nmol/ml] and the lung homogenate [(9.54 +/- 0.92) nmol/mg pro] of the non-treatment group significantly increased compared with the control group (P < 0.01), the activities of GSH-Px and SOD in plasma at 3 d were significantly less than the control group (P < 0.05 or P < 0.01), the activities of GSH-Px (3 d, 7 d) and SOD (7 d, 14 d) in the lung homogenate were significantly less than the control group (P < 0.05). There were no significant difference in the levels of MDA both in plasma and the lung homogenate between the treatment group and the non-treatment group (P > 0.05). The SOD activities of treatment group on the third day was significantly increased compared with the non-treatment group (P < 0.01 or P < 0.05). Although the activities of GSH-Px in plasma and the lung homogenate of the treatment group on the third day were increased, there was no significantly difference compared with the non-treatment group (P > 0.05). The integral score of pulmonary fibrosis in the treatment group were significantly lower than in the non-treatment group (P < 0.01). CONCLUSION: TET has antagonistic effect against acute toxicity of paraquat through significant reduction of pulmonary fibrosis. SN - 1001-9391 UR - https://www.unboundmedicine.com/medline/citation/19272249/[Experimental_study_on_therapeutic_efficacy_of_tetrandrine_on_lung_injury_induced_by_acute_of_paraquat_poisoning]_ DB - PRIME DP - Unbound Medicine ER -