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Vitamin C intake and the risk of gout in men: a prospective study.

Abstract

BACKGROUND

Several metabolic studies and a recent double-blind, placebo-controlled, randomized trial have shown that higher vitamin C intake significantly reduces serum uric acid levels. Yet the relation with risk of gout is unknown.

METHODS

We prospectively examined, from 1986 through 2006, the relation between vitamin C intake and risk of incident gout in 46 994 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout. Vitamin C intake was assessed every 4 years through validated questionnaires.

RESULTS

During the 20 years of follow-up, we documented 1317 confirmed incident cases of gout. Compared with men with vitamin C intake less than 250 mg/d, the multivariate relative risk (RR) of gout was 0.83 (95% confidence interval [CI], 0.71-0.97) for total vitamin C intake of 500 to 999 mg/d, 0.66 (0.52-0.86) for 1000 to 1499 mg/d, and 0.55 (0.38-0.80) for 1500 mg/d or greater (P < .001 for trend). The multivariate RR per 500-mg increase in total daily vitamin C intake was 0.83 (95% CI, 0.77-0.90). Compared with men who did not use supplemental vitamin C, the multivariate RR of gout was 0.66 (95% CI, 0.49-0.88) for supplemental vitamin C intake of 1000 to 1499 mg/d and 0.55 (0.36-0.86) for 1500 mg/d or greater (P < .001 for trend).

CONCLUSIONS

Higher vitamin C intake is independently associated with a lower risk of gout. Supplemental vitamin C intake may be beneficial in the prevention of gout.

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  • Authors+Show Affiliations

    ,

    Division of Rheumatology, Department of Medicine, Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, Canada. hchoius@bu.edu

    ,

    Source

    Archives of internal medicine 169:5 2009 Mar 09 pg 502-7

    MeSH

    Adult
    Aged
    Ascorbic Acid
    Gout
    Humans
    Incidence
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Uric Acid
    Vitamins

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19273781

    Citation

    Choi, Hyon K., et al. "Vitamin C Intake and the Risk of Gout in Men: a Prospective Study." Archives of Internal Medicine, vol. 169, no. 5, 2009, pp. 502-7.
    Choi HK, Gao X, Curhan G. Vitamin C intake and the risk of gout in men: a prospective study. Arch Intern Med. 2009;169(5):502-7.
    Choi, H. K., Gao, X., & Curhan, G. (2009). Vitamin C intake and the risk of gout in men: a prospective study. Archives of Internal Medicine, 169(5), pp. 502-7. doi:10.1001/archinternmed.2008.606.
    Choi HK, Gao X, Curhan G. Vitamin C Intake and the Risk of Gout in Men: a Prospective Study. Arch Intern Med. 2009 Mar 9;169(5):502-7. PubMed PMID: 19273781.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin C intake and the risk of gout in men: a prospective study. AU - Choi,Hyon K, AU - Gao,Xiang, AU - Curhan,Gary, PY - 2009/3/11/entrez PY - 2009/3/11/pubmed PY - 2009/4/25/medline SP - 502 EP - 7 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 169 IS - 5 N2 - BACKGROUND: Several metabolic studies and a recent double-blind, placebo-controlled, randomized trial have shown that higher vitamin C intake significantly reduces serum uric acid levels. Yet the relation with risk of gout is unknown. METHODS: We prospectively examined, from 1986 through 2006, the relation between vitamin C intake and risk of incident gout in 46 994 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout. Vitamin C intake was assessed every 4 years through validated questionnaires. RESULTS: During the 20 years of follow-up, we documented 1317 confirmed incident cases of gout. Compared with men with vitamin C intake less than 250 mg/d, the multivariate relative risk (RR) of gout was 0.83 (95% confidence interval [CI], 0.71-0.97) for total vitamin C intake of 500 to 999 mg/d, 0.66 (0.52-0.86) for 1000 to 1499 mg/d, and 0.55 (0.38-0.80) for 1500 mg/d or greater (P < .001 for trend). The multivariate RR per 500-mg increase in total daily vitamin C intake was 0.83 (95% CI, 0.77-0.90). Compared with men who did not use supplemental vitamin C, the multivariate RR of gout was 0.66 (95% CI, 0.49-0.88) for supplemental vitamin C intake of 1000 to 1499 mg/d and 0.55 (0.36-0.86) for 1500 mg/d or greater (P < .001 for trend). CONCLUSIONS: Higher vitamin C intake is independently associated with a lower risk of gout. Supplemental vitamin C intake may be beneficial in the prevention of gout. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/19273781/full_citation L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2008.606 DB - PRIME DP - Unbound Medicine ER -