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Metal complexes, their cellular targets and potential for cancer therapy.
Curr Pharm Des. 2009; 15(7):777-91.CP

Abstract

The development of metal complexes with anticancer activity has had an enormous impact on cancer chemotherapy. The discovery of cisplatin in the 1960's represented a landmark achievement and ushered in a new era in cancer treatment. Despite the fact that cisplatin has achieved significant clinical benefit for several types of solid tumors, its effectiveness has been hampered by toxic side effects and tumor resistance that often leads to the occurrence of secondary malignancies. However, discovery and use of cisplatin have encouraged investigators to search for and develop novel non platinum-containing metal species with superior anti-cancer activity and low side effects. As examples, gallium salts and gold complexes have been evaluated in phase I and phase II trials. Copper-chelating compounds have also shown promising results in both preclinical and clinical studies. This review provides a comprehensive overview of various non platinum metal complexes and metal-chelating compounds and discusses their potential molecular targets in tumor cells and their applications in cancer therapy.

Authors+Show Affiliations

The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19275642

Citation

Chen, Di, et al. "Metal Complexes, Their Cellular Targets and Potential for Cancer Therapy." Current Pharmaceutical Design, vol. 15, no. 7, 2009, pp. 777-91.
Chen D, Milacic V, Frezza M, et al. Metal complexes, their cellular targets and potential for cancer therapy. Curr Pharm Des. 2009;15(7):777-91.
Chen, D., Milacic, V., Frezza, M., & Dou, Q. P. (2009). Metal complexes, their cellular targets and potential for cancer therapy. Current Pharmaceutical Design, 15(7), 777-91.
Chen D, et al. Metal Complexes, Their Cellular Targets and Potential for Cancer Therapy. Curr Pharm Des. 2009;15(7):777-91. PubMed PMID: 19275642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metal complexes, their cellular targets and potential for cancer therapy. AU - Chen,Di, AU - Milacic,Vesna, AU - Frezza,Michael, AU - Dou,Q Ping, PY - 2009/3/12/entrez PY - 2009/3/12/pubmed PY - 2009/4/18/medline SP - 777 EP - 91 JF - Current pharmaceutical design JO - Curr. Pharm. Des. VL - 15 IS - 7 N2 - The development of metal complexes with anticancer activity has had an enormous impact on cancer chemotherapy. The discovery of cisplatin in the 1960's represented a landmark achievement and ushered in a new era in cancer treatment. Despite the fact that cisplatin has achieved significant clinical benefit for several types of solid tumors, its effectiveness has been hampered by toxic side effects and tumor resistance that often leads to the occurrence of secondary malignancies. However, discovery and use of cisplatin have encouraged investigators to search for and develop novel non platinum-containing metal species with superior anti-cancer activity and low side effects. As examples, gallium salts and gold complexes have been evaluated in phase I and phase II trials. Copper-chelating compounds have also shown promising results in both preclinical and clinical studies. This review provides a comprehensive overview of various non platinum metal complexes and metal-chelating compounds and discusses their potential molecular targets in tumor cells and their applications in cancer therapy. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/19275642/Metal_complexes_their_cellular_targets_and_potential_for_cancer_therapy_ L2 - http://www.eurekaselect.com/68835/article DB - PRIME DP - Unbound Medicine ER -