Tags

Type your tag names separated by a space and hit enter

ABO blood group and the risk of pancreatic cancer.
J Natl Cancer Inst 2009; 101(6):424-31JNCI

Abstract

BACKGROUND

Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies.

METHODS

We separately examined the relationship between ABO blood type and the risk of incident pancreatic cancer in two large, independent, prospective cohort studies (the Nurses' Health Study and Health Professionals Follow-up Study) that collected blood group data on 107 503 US health professionals. Hazard ratios for pancreatic cancer by ABO blood type were calculated using Cox proportional hazards models with adjustment for other known risk factors, including age, tobacco use, body mass index, physical activity, and history of diabetes mellitus. All statistical tests were two-sided.

RESULTS

During 927 995 person-years of follow-up, 316 participants developed pancreatic cancer. ABO blood type was associated with the risk of developing pancreatic cancer (P = .004; log-rank test). Compared with participants with blood group O, those with blood groups A, AB, or B were more likely to develop pancreatic cancer (adjusted hazard ratios for incident pancreatic cancer were 1.32 [95% confidence interval {CI} = 1.02 to 1.72], 1.51 [95% CI = 1.02 to 2.23], and 1.72 [95% CI = 1.25 to 2.38], respectively). The association between blood type and pancreatic cancer risk was nearly identical in the two cohorts (P(interaction) = .97). Overall, 17% of the pancreatic cancer cases were attributable to inheriting a non-O blood group (blood group A, B, or AB). The age-adjusted incidence rates for pancreatic cancer per 100 000 person-years were 27 (95% CI = 23 to 33) for participants with blood type O, 36 (95% CI = 26 to 50) for those with blood type A, 41 (95% CI = 31 to 56) for those with blood type AB, and 46 (95% CI = 32 to 68) for those with blood type B.

CONCLUSIONS

In two large, independent populations, ABO blood type was statistically significantly associated with the risk of pancreatic cancer. Further studies are necessary to define the mechanisms by which ABO blood type or closely linked genetic variants may influence pancreatic cancer risk.

Authors+Show Affiliations

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. bwolpin@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19276450

Citation

Wolpin, Brian M., et al. "ABO Blood Group and the Risk of Pancreatic Cancer." Journal of the National Cancer Institute, vol. 101, no. 6, 2009, pp. 424-31.
Wolpin BM, Chan AT, Hartge P, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst. 2009;101(6):424-31.
Wolpin, B. M., Chan, A. T., Hartge, P., Chanock, S. J., Kraft, P., Hunter, D. J., ... Fuchs, C. S. (2009). ABO blood group and the risk of pancreatic cancer. Journal of the National Cancer Institute, 101(6), pp. 424-31. doi:10.1093/jnci/djp020.
Wolpin BM, et al. ABO Blood Group and the Risk of Pancreatic Cancer. J Natl Cancer Inst. 2009 Mar 18;101(6):424-31. PubMed PMID: 19276450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ABO blood group and the risk of pancreatic cancer. AU - Wolpin,Brian M, AU - Chan,Andrew T, AU - Hartge,Patricia, AU - Chanock,Stephen J, AU - Kraft,Peter, AU - Hunter,David J, AU - Giovannucci,Edward L, AU - Fuchs,Charles S, Y1 - 2009/03/10/ PY - 2009/3/12/entrez PY - 2009/3/12/pubmed PY - 2009/4/30/medline SP - 424 EP - 31 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 101 IS - 6 N2 - BACKGROUND: Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies. METHODS: We separately examined the relationship between ABO blood type and the risk of incident pancreatic cancer in two large, independent, prospective cohort studies (the Nurses' Health Study and Health Professionals Follow-up Study) that collected blood group data on 107 503 US health professionals. Hazard ratios for pancreatic cancer by ABO blood type were calculated using Cox proportional hazards models with adjustment for other known risk factors, including age, tobacco use, body mass index, physical activity, and history of diabetes mellitus. All statistical tests were two-sided. RESULTS: During 927 995 person-years of follow-up, 316 participants developed pancreatic cancer. ABO blood type was associated with the risk of developing pancreatic cancer (P = .004; log-rank test). Compared with participants with blood group O, those with blood groups A, AB, or B were more likely to develop pancreatic cancer (adjusted hazard ratios for incident pancreatic cancer were 1.32 [95% confidence interval {CI} = 1.02 to 1.72], 1.51 [95% CI = 1.02 to 2.23], and 1.72 [95% CI = 1.25 to 2.38], respectively). The association between blood type and pancreatic cancer risk was nearly identical in the two cohorts (P(interaction) = .97). Overall, 17% of the pancreatic cancer cases were attributable to inheriting a non-O blood group (blood group A, B, or AB). The age-adjusted incidence rates for pancreatic cancer per 100 000 person-years were 27 (95% CI = 23 to 33) for participants with blood type O, 36 (95% CI = 26 to 50) for those with blood type A, 41 (95% CI = 31 to 56) for those with blood type AB, and 46 (95% CI = 32 to 68) for those with blood type B. CONCLUSIONS: In two large, independent populations, ABO blood type was statistically significantly associated with the risk of pancreatic cancer. Further studies are necessary to define the mechanisms by which ABO blood type or closely linked genetic variants may influence pancreatic cancer risk. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/19276450/full_citation L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djp020 DB - PRIME DP - Unbound Medicine ER -