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Hemodynamic and vascular response to resistance exercise with L-arginine.
Med Sci Sports Exerc 2009; 41(4):773-9MS

Abstract

PURPOSE

L-arginine, the precursor to nitric oxide (NO), has been shown to improve endothelial function in patients with endothelial dysfunction. Resistance exercise has been shown to increase arterial stiffness acutely with no definitive cause. It is possible that a reduction in NO bioavailability is responsible for this. The purpose of this study was to examine the effect of acute L-arginine supplementation and resistance exercise on arterial function.

METHODS

Eighteen (N = 18) young men (24.2 +/- 0.7 yr) volunteered for this study. In a crossover design, subjects underwent body composition testing, 1-repetition maximum testing for the bench press and the biceps curls and performed two acute bouts of resistance exercise in which they consumed either placebo or 7 g L-arginine before each resistance exercise bout. Anthropometric measures, augmentation index (AIx), arterial stiffness, and forearm blood flow (FBF) were assessed before and after each treatment condition.

RESULTS

There were significant (P < 0.05) time effects after the resistance exercise; there was a reduction in brachial stiffness (P = 0.0001), an increase in central aortic stiffness (P = 0.004), an increase in AIx (P = 0.023), an increase in FBF (P = 0.000), and an increase in arm circumference (P = 0.0001) after exercise.

CONCLUSIONS

The increase in central arterial stiffness and wave reflection was not attenuated by acute supplementation with L-arginine; furthermore, blood flow was not augmented with supplementation. On the basis of these data, l-arginine does not appear to change the hemodynamic and vascular responses to resistance exercise.

Authors+Show Affiliations

Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19276857

Citation

Fahs, Christopher A., et al. "Hemodynamic and Vascular Response to Resistance Exercise With L-arginine." Medicine and Science in Sports and Exercise, vol. 41, no. 4, 2009, pp. 773-9.
Fahs CA, Heffernan KS, Fernhall B. Hemodynamic and vascular response to resistance exercise with L-arginine. Med Sci Sports Exerc. 2009;41(4):773-9.
Fahs, C. A., Heffernan, K. S., & Fernhall, B. (2009). Hemodynamic and vascular response to resistance exercise with L-arginine. Medicine and Science in Sports and Exercise, 41(4), pp. 773-9. doi:10.1249/MSS.0b013e3181909d9d.
Fahs CA, Heffernan KS, Fernhall B. Hemodynamic and Vascular Response to Resistance Exercise With L-arginine. Med Sci Sports Exerc. 2009;41(4):773-9. PubMed PMID: 19276857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodynamic and vascular response to resistance exercise with L-arginine. AU - Fahs,Christopher A, AU - Heffernan,Kevin S, AU - Fernhall,Bo, PY - 2009/3/12/entrez PY - 2009/3/12/pubmed PY - 2009/7/14/medline SP - 773 EP - 9 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 41 IS - 4 N2 - PURPOSE: L-arginine, the precursor to nitric oxide (NO), has been shown to improve endothelial function in patients with endothelial dysfunction. Resistance exercise has been shown to increase arterial stiffness acutely with no definitive cause. It is possible that a reduction in NO bioavailability is responsible for this. The purpose of this study was to examine the effect of acute L-arginine supplementation and resistance exercise on arterial function. METHODS: Eighteen (N = 18) young men (24.2 +/- 0.7 yr) volunteered for this study. In a crossover design, subjects underwent body composition testing, 1-repetition maximum testing for the bench press and the biceps curls and performed two acute bouts of resistance exercise in which they consumed either placebo or 7 g L-arginine before each resistance exercise bout. Anthropometric measures, augmentation index (AIx), arterial stiffness, and forearm blood flow (FBF) were assessed before and after each treatment condition. RESULTS: There were significant (P < 0.05) time effects after the resistance exercise; there was a reduction in brachial stiffness (P = 0.0001), an increase in central aortic stiffness (P = 0.004), an increase in AIx (P = 0.023), an increase in FBF (P = 0.000), and an increase in arm circumference (P = 0.0001) after exercise. CONCLUSIONS: The increase in central arterial stiffness and wave reflection was not attenuated by acute supplementation with L-arginine; furthermore, blood flow was not augmented with supplementation. On the basis of these data, l-arginine does not appear to change the hemodynamic and vascular responses to resistance exercise. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/19276857/Hemodynamic_and_vascular_response_to_resistance_exercise_with_L_arginine_ L2 - http://Insights.ovid.com/pubmed?pmid=19276857 DB - PRIME DP - Unbound Medicine ER -