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Simple sequence repeat (SSR)-based gene diversity in Burkholderia pseudomallei and Burkholderia mallei.
Mol Cells. 2009 Feb 28; 27(2):237-41.MC

Abstract

Pathogens Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) contain a large number (> 12,000) of Simple Sequence Repeats (SSRs). To study the extent to which these features have contributed to the diversification of genes, we have conducted comparative studies with nineteen genomes of these bacteria. We found 210 genes with characteristic types of SSR variations. SSRs with nonamer repeat units were the most abundant, followed by hexamers and trimers. Amino acids with smaller and nonpolar R-groups are preferred to be encoded by the variant SSRs, perhaps due to their minimal impacts to protein functionality. A majority of these genes appears to code for surface or secreted proteins that may directly interact with the host factors during pathogenesis or other environmental factors. There also are others that encode diverse functions in the cytoplasm, and this protein variability may reflect an extensive involvement of phase variation in survival and adaptation of these pathogens.

Authors+Show Affiliations

Department of Medicine, College of Medicine, Korea University, Seoul, 136-705, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19277507

Citation

Song, Han, et al. "Simple Sequence Repeat (SSR)-based Gene Diversity in Burkholderia Pseudomallei and Burkholderia Mallei." Molecules and Cells, vol. 27, no. 2, 2009, pp. 237-41.
Song H, Hwang J, Myung J, et al. Simple sequence repeat (SSR)-based gene diversity in Burkholderia pseudomallei and Burkholderia mallei. Mol Cells. 2009;27(2):237-41.
Song, H., Hwang, J., Myung, J., Seo, H., Yi, H., Sim, H. S., Kim, B. S., Nierman, W. C., & Kim, H. S. (2009). Simple sequence repeat (SSR)-based gene diversity in Burkholderia pseudomallei and Burkholderia mallei. Molecules and Cells, 27(2), 237-41. https://doi.org/10.1007/s10059-009-0029-8
Song H, et al. Simple Sequence Repeat (SSR)-based Gene Diversity in Burkholderia Pseudomallei and Burkholderia Mallei. Mol Cells. 2009 Feb 28;27(2):237-41. PubMed PMID: 19277507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simple sequence repeat (SSR)-based gene diversity in Burkholderia pseudomallei and Burkholderia mallei. AU - Song,Han, AU - Hwang,Junghyun, AU - Myung,Jaehee, AU - Seo,Hyoseok, AU - Yi,Hyojeong, AU - Sim,Hee-Sun, AU - Kim,Bong-Su, AU - Nierman,William C, AU - Kim,Heenam Stanley, Y1 - 2009/02/20/ PY - 2008/11/18/received PY - 2008/11/25/accepted PY - 2009/3/12/entrez PY - 2009/3/12/pubmed PY - 2009/6/3/medline SP - 237 EP - 41 JF - Molecules and cells JO - Mol Cells VL - 27 IS - 2 N2 - Pathogens Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) contain a large number (> 12,000) of Simple Sequence Repeats (SSRs). To study the extent to which these features have contributed to the diversification of genes, we have conducted comparative studies with nineteen genomes of these bacteria. We found 210 genes with characteristic types of SSR variations. SSRs with nonamer repeat units were the most abundant, followed by hexamers and trimers. Amino acids with smaller and nonpolar R-groups are preferred to be encoded by the variant SSRs, perhaps due to their minimal impacts to protein functionality. A majority of these genes appears to code for surface or secreted proteins that may directly interact with the host factors during pathogenesis or other environmental factors. There also are others that encode diverse functions in the cytoplasm, and this protein variability may reflect an extensive involvement of phase variation in survival and adaptation of these pathogens. SN - 1016-8478 UR - https://www.unboundmedicine.com/medline/citation/19277507/Simple_sequence_repeat__SSR__based_gene_diversity_in_Burkholderia_pseudomallei_and_Burkholderia_mallei_ L2 - http://www.molcells.org/journal/view.html?year=2009&volume=27&number=2&spage=237 DB - PRIME DP - Unbound Medicine ER -