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Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice.
Phytother Res 2009; 23(10):1426-30PR

Abstract

Hypoglycemic effects of malonyl-ginsenosides (MGR), extracted from roots of Panax ginseng, were examined in streptozotocin- (STZ-) induced diabetic mice. Animals received daily intravenous injections of MGR in doses of 30, 60, 120 mg/kg. At a dose of 120 mg/kg, MGR reduced the fasting blood glucose level of diabetic mice by 77.8% (76.7 +/- 8.5 mg/dl versus 345.2 +/- 35.8 mg/dl, P < 0.01). The same dose also showed a marked improvement in glucose tolerance of 80% (75.3 +/- 10.8 mg/dl versus 375.6 +/- 43.3 mg/dl, P < 0.01) in diabetic mice after four days. The alkali hydrolysis productions of MGR, ginseng panaxadiol (PDS), malonic acid and a mixture of malonic acid with PDS, showed no effects on fasting blood glucose levels indicated the hypoglycemic effect of MGR relied on their unique esterified chemical structures. The findings from this study suggest that MGR extracted from Panax ginseng may be prescribed as adjunct to drug treatment for controlling diabetes mellitus.

Authors+Show Affiliations

Institute of Agricultural Modernization, Jilin Agricultural University, Changchun 130118, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19277974

Citation

Liu, Zhi, et al. "Hypoglycemic Effects of Malonyl-ginsenosides Extracted From Roots of Panax Ginseng On Streptozotocin-induced Diabetic Mice." Phytotherapy Research : PTR, vol. 23, no. 10, 2009, pp. 1426-30.
Liu Z, Wang LJ, Li X, et al. Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. Phytother Res. 2009;23(10):1426-30.
Liu, Z., Wang, L. J., Li, X., Hu, J. N., Chen, Y., Ruan, C. C., & Sun, G. Z. (2009). Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. Phytotherapy Research : PTR, 23(10), pp. 1426-30. doi:10.1002/ptr.2796.
Liu Z, et al. Hypoglycemic Effects of Malonyl-ginsenosides Extracted From Roots of Panax Ginseng On Streptozotocin-induced Diabetic Mice. Phytother Res. 2009;23(10):1426-30. PubMed PMID: 19277974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. AU - Liu,Zhi, AU - Wang,Li-Juan, AU - Li,Xiang, AU - Hu,Jiang-Ning, AU - Chen,Yun, AU - Ruan,Chang-Chun, AU - Sun,Guang-Zhi, PY - 2009/3/12/entrez PY - 2009/3/12/pubmed PY - 2010/1/27/medline SP - 1426 EP - 30 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 10 N2 - Hypoglycemic effects of malonyl-ginsenosides (MGR), extracted from roots of Panax ginseng, were examined in streptozotocin- (STZ-) induced diabetic mice. Animals received daily intravenous injections of MGR in doses of 30, 60, 120 mg/kg. At a dose of 120 mg/kg, MGR reduced the fasting blood glucose level of diabetic mice by 77.8% (76.7 +/- 8.5 mg/dl versus 345.2 +/- 35.8 mg/dl, P < 0.01). The same dose also showed a marked improvement in glucose tolerance of 80% (75.3 +/- 10.8 mg/dl versus 375.6 +/- 43.3 mg/dl, P < 0.01) in diabetic mice after four days. The alkali hydrolysis productions of MGR, ginseng panaxadiol (PDS), malonic acid and a mixture of malonic acid with PDS, showed no effects on fasting blood glucose levels indicated the hypoglycemic effect of MGR relied on their unique esterified chemical structures. The findings from this study suggest that MGR extracted from Panax ginseng may be prescribed as adjunct to drug treatment for controlling diabetes mellitus. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/19277974/Hypoglycemic_effects_of_malonyl_ginsenosides_extracted_from_roots_of_Panax_ginseng_on_streptozotocin_induced_diabetic_mice_ L2 - https://doi.org/10.1002/ptr.2796 DB - PRIME DP - Unbound Medicine ER -