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The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing.
Brief Funct Genomic Proteomic. 2009 Jan; 8(1):60-7.BF

Abstract

Removal of introns during pre-mRNA splicing is a critical process in gene expression, and understanding its control at both single-gene and genomic levels is one of the great challenges in Biology. Splicing takes place in a dynamic, large ribonucleoprotein complex known as the spliceosome. Combining Genetics and Biochemistry, Saccharomyces cerevisiae provides insights into its mechanisms, including its regulation by RNA-protein interactions. Recent genome-wide analyses indicate that regulated splicing is broad and biologically relevant even in organisms with a relatively simple intronic structure, such as yeast. Furthermore, the possibility of coordination in splicing regulation at genomic level is becoming clear in this model organism. This should provide a valuable system to approach the complex problem of the role of regulated splicing in genomic expression.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Meyer M
Gene Regulation Program, Centre de Regulació Genòmica, Dr Aiguader 88, Barcelona, Spain.
Vilardell J
No affiliation info available

MeSH

Fungal ProteinsGene Expression RegulationGene Expression Regulation, FungalGenomeGenome, FungalIntronsMeiosisNuclear ProteinsProtein Interaction MappingRNA PrecursorsRNA SplicingRNA-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19279072

Citation

Meyer, Markus, and Josep Vilardell. "The Quest for a Message: Budding Yeast, a Model Organism to Study the Control of pre-mRNA Splicing." Briefings in Functional Genomics & Proteomics, vol. 8, no. 1, 2009, pp. 60-7.
Meyer M, Vilardell J. The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Brief Funct Genomic Proteomic. 2009;8(1):60-7.
Meyer, M., & Vilardell, J. (2009). The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Briefings in Functional Genomics & Proteomics, 8(1), 60-7. https://doi.org/10.1093/bfgp/elp002
Meyer M, Vilardell J. The Quest for a Message: Budding Yeast, a Model Organism to Study the Control of pre-mRNA Splicing. Brief Funct Genomic Proteomic. 2009;8(1):60-7. PubMed PMID: 19279072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. AU - Meyer,Markus, AU - Vilardell,Josep, Y1 - 2009/03/11/ PY - 2009/3/13/entrez PY - 2009/3/13/pubmed PY - 2009/7/16/medline SP - 60 EP - 7 JF - Briefings in functional genomics & proteomics JO - Brief Funct Genomic Proteomic VL - 8 IS - 1 N2 - Removal of introns during pre-mRNA splicing is a critical process in gene expression, and understanding its control at both single-gene and genomic levels is one of the great challenges in Biology. Splicing takes place in a dynamic, large ribonucleoprotein complex known as the spliceosome. Combining Genetics and Biochemistry, Saccharomyces cerevisiae provides insights into its mechanisms, including its regulation by RNA-protein interactions. Recent genome-wide analyses indicate that regulated splicing is broad and biologically relevant even in organisms with a relatively simple intronic structure, such as yeast. Furthermore, the possibility of coordination in splicing regulation at genomic level is becoming clear in this model organism. This should provide a valuable system to approach the complex problem of the role of regulated splicing in genomic expression. SN - 1477-4062 UR - https://www.unboundmedicine.com/medline/citation/19279072/The_quest_for_a_message:_budding_yeast_a_model_organism_to_study_the_control_of_pre_mRNA_splicing_ DB - PRIME DP - Unbound Medicine ER -