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CRF enhancement of GIRK channel-mediated transmission in dopamine neurons.
Neuropsychopharmacology. 2009 Jul; 34(8):1926-35.N

Abstract

Dopamine neurons in the ventral midbrain contribute to learning and memory of natural and drug-related rewards. Corticotropin-releasing factor (CRF), a stress-related peptide, is thought to be involved in aspects of relapse following drug withdrawal, but the cellular actions are poorly understood. This study investigates the action of CRF on G-protein-linked inhibitory postsynaptic currents (IPSCs) mediated by GIRK (Kir3) channels in dopamine neurons. CRF enhanced the amplitude and slowed the kinetics of IPSCs following activation of D2-dopamine and GABA(B) receptors. This action was postsynaptic and dependent on the CRF(1) receptor. The enhancement induced by CRF was attenuated by repeated in vivo exposures to psychostimulants or restraint stress. The results indicate that CRF influences dopamine- and GABA-mediated inhibition in the midbrain, suggesting implications for the chronic actions of psychostimulants and stress on dopamine-mediated behaviors.

Authors+Show Affiliations

Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19279570

Citation

Beckstead, Michael J., et al. "CRF Enhancement of GIRK Channel-mediated Transmission in Dopamine Neurons." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 34, no. 8, 2009, pp. 1926-35.
Beckstead MJ, Gantz SC, Ford CP, et al. CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. Neuropsychopharmacology. 2009;34(8):1926-35.
Beckstead, M. J., Gantz, S. C., Ford, C. P., Stenzel-Poore, M. P., Phillips, P. E., Mark, G. P., & Williams, J. T. (2009). CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 34(8), 1926-35. https://doi.org/10.1038/npp.2009.25
Beckstead MJ, et al. CRF Enhancement of GIRK Channel-mediated Transmission in Dopamine Neurons. Neuropsychopharmacology. 2009;34(8):1926-35. PubMed PMID: 19279570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. AU - Beckstead,Michael J, AU - Gantz,Stephanie C, AU - Ford,Christopher P, AU - Stenzel-Poore,Mary P, AU - Phillips,Paul Em, AU - Mark,Gregory P, AU - Williams,John T, Y1 - 2009/03/11/ PY - 2009/3/13/entrez PY - 2009/3/13/pubmed PY - 2009/9/3/medline SP - 1926 EP - 35 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 34 IS - 8 N2 - Dopamine neurons in the ventral midbrain contribute to learning and memory of natural and drug-related rewards. Corticotropin-releasing factor (CRF), a stress-related peptide, is thought to be involved in aspects of relapse following drug withdrawal, but the cellular actions are poorly understood. This study investigates the action of CRF on G-protein-linked inhibitory postsynaptic currents (IPSCs) mediated by GIRK (Kir3) channels in dopamine neurons. CRF enhanced the amplitude and slowed the kinetics of IPSCs following activation of D2-dopamine and GABA(B) receptors. This action was postsynaptic and dependent on the CRF(1) receptor. The enhancement induced by CRF was attenuated by repeated in vivo exposures to psychostimulants or restraint stress. The results indicate that CRF influences dopamine- and GABA-mediated inhibition in the midbrain, suggesting implications for the chronic actions of psychostimulants and stress on dopamine-mediated behaviors. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/19279570/CRF_enhancement_of_GIRK_channel_mediated_transmission_in_dopamine_neurons_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19279570/ DB - PRIME DP - Unbound Medicine ER -