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Interrelationship between erythropoietin and erythropoiesis: insights from renal transplantation.
Am J Kidney Dis. 1991 Oct; 18(4 Suppl 1):54-6.AJ

Abstract

In successful renal transplant recipients, transient and modest increases in endogenous erythropoietin (Epo) reverse anemia, whereas in dialysis patients, sustained administration of large doses of exogenous Epo is required for the correction of uremic anemia. Moreover, in transplant recipients, serum Epo returns to normal as the hematocrit level increases to greater than 32%. Thereafter, the hematocrit continues to increase to normal levels, while serum Epo remains in the normal range. Thus, the restoration of renal function may improve the erythropoietic response to Epo, and/or erythropoiesis in transplant patients may be stimulated by factors other than, or in addition to, Epo. In early posttransplant patients who develop erythrocytosis, serum Epo levels are often elevated, while in long-term transplant recipients, erythrocytotic patients (with normal serum ferritin) have normal serum Epo levels. On the other hand, in long-term transplant recipients with low serum ferritin, circulating Epo levels are elevated, even in patients with no overt anemia. This suggests a possible interaction between body iron store status and the synthesis of Epo.

Authors+Show Affiliations

Division of Nephrology, Sepulveda VAMC, CA 91343.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

1928080

Citation

Lee, D B.. "Interrelationship Between Erythropoietin and Erythropoiesis: Insights From Renal Transplantation." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 18, no. 4 Suppl 1, 1991, pp. 54-6.
Lee DB. Interrelationship between erythropoietin and erythropoiesis: insights from renal transplantation. Am J Kidney Dis. 1991;18(4 Suppl 1):54-6.
Lee, D. B. (1991). Interrelationship between erythropoietin and erythropoiesis: insights from renal transplantation. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 18(4 Suppl 1), 54-6.
Lee DB. Interrelationship Between Erythropoietin and Erythropoiesis: Insights From Renal Transplantation. Am J Kidney Dis. 1991;18(4 Suppl 1):54-6. PubMed PMID: 1928080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interrelationship between erythropoietin and erythropoiesis: insights from renal transplantation. A1 - Lee,D B, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 54 EP - 6 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 18 IS - 4 Suppl 1 N2 - In successful renal transplant recipients, transient and modest increases in endogenous erythropoietin (Epo) reverse anemia, whereas in dialysis patients, sustained administration of large doses of exogenous Epo is required for the correction of uremic anemia. Moreover, in transplant recipients, serum Epo returns to normal as the hematocrit level increases to greater than 32%. Thereafter, the hematocrit continues to increase to normal levels, while serum Epo remains in the normal range. Thus, the restoration of renal function may improve the erythropoietic response to Epo, and/or erythropoiesis in transplant patients may be stimulated by factors other than, or in addition to, Epo. In early posttransplant patients who develop erythrocytosis, serum Epo levels are often elevated, while in long-term transplant recipients, erythrocytotic patients (with normal serum ferritin) have normal serum Epo levels. On the other hand, in long-term transplant recipients with low serum ferritin, circulating Epo levels are elevated, even in patients with no overt anemia. This suggests a possible interaction between body iron store status and the synthesis of Epo. SN - 0272-6386 UR - https://www.unboundmedicine.com/medline/citation/1928080/Interrelationship_between_erythropoietin_and_erythropoiesis:_insights_from_renal_transplantation_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -