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The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali.
Parasitology. 2009 Nov; 136(13):1851-7.P

Abstract

The aim of this study was to assess the effect of two doses of 40 mg/kg praziquantel with 2 weeks interval versus a standard single dose of 40 mg/kg on cure rates, egg reduction, intensity of infection, and micro-haematuria in Schistosoma haematobium infections. A randomised controlled intervention study was carried out among school-aged children in two different endemic settings with follow-up at 3, 6 and 18 months following drug administration. Differences in cure rates between the two treatment regimens were not significant. However, in high transmission areas, the double treatment regimen was more effective in egg reduction than single treatment regimen and the difference in egg reduction between the two treatments was significant at 3 months (P<0.005), 6 months (P<0.0001) and 18 months (P<0.003) after treatment. There was a significant difference in the effect of the two treatments on prevalence of micro-haematuria at 18-month follow-up in both Koulikoro (P<0.001) and Selingue (P<0.003). The study shows that although no significant difference could be observed in the overall cure-rates between the two treatment regimens, the effect of double treatment was a significant reduction in infection intensity as well as micro-haematuria which may have a great impact in reducing subtle morbidity.

Authors+Show Affiliations

Institut National de Recherche en Santé Publique (INRSP), B.P. 1771, Bamako, Mali. msacko@afribonemali.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19281636

Citation

Sacko, M, et al. "The Effect of Single Dose Versus Two Doses of Praziquantel On Schistosoma Haematobium Infection and Pathology Among School-aged Children in Mali." Parasitology, vol. 136, no. 13, 2009, pp. 1851-7.
Sacko M, Magnussen P, Traoré M, et al. The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali. Parasitology. 2009;136(13):1851-7.
Sacko, M., Magnussen, P., Traoré, M., Landouré, A., Doucouré, A., Reimert, C. M., & Vennervald, B. J. (2009). The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali. Parasitology, 136(13), 1851-7. https://doi.org/10.1017/S0031182008000486
Sacko M, et al. The Effect of Single Dose Versus Two Doses of Praziquantel On Schistosoma Haematobium Infection and Pathology Among School-aged Children in Mali. Parasitology. 2009;136(13):1851-7. PubMed PMID: 19281636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali. AU - Sacko,M, AU - Magnussen,P, AU - Traoré,M, AU - Landouré,A, AU - Doucouré,A, AU - Reimert,C M, AU - Vennervald,B J, Y1 - 2009/03/13/ PY - 2009/3/14/entrez PY - 2009/3/14/pubmed PY - 2010/2/6/medline SP - 1851 EP - 7 JF - Parasitology JO - Parasitology VL - 136 IS - 13 N2 - The aim of this study was to assess the effect of two doses of 40 mg/kg praziquantel with 2 weeks interval versus a standard single dose of 40 mg/kg on cure rates, egg reduction, intensity of infection, and micro-haematuria in Schistosoma haematobium infections. A randomised controlled intervention study was carried out among school-aged children in two different endemic settings with follow-up at 3, 6 and 18 months following drug administration. Differences in cure rates between the two treatment regimens were not significant. However, in high transmission areas, the double treatment regimen was more effective in egg reduction than single treatment regimen and the difference in egg reduction between the two treatments was significant at 3 months (P<0.005), 6 months (P<0.0001) and 18 months (P<0.003) after treatment. There was a significant difference in the effect of the two treatments on prevalence of micro-haematuria at 18-month follow-up in both Koulikoro (P<0.001) and Selingue (P<0.003). The study shows that although no significant difference could be observed in the overall cure-rates between the two treatment regimens, the effect of double treatment was a significant reduction in infection intensity as well as micro-haematuria which may have a great impact in reducing subtle morbidity. SN - 1469-8161 UR - https://www.unboundmedicine.com/medline/citation/19281636/The_effect_of_single_dose_versus_two_doses_of_praziquantel_on_Schistosoma_haematobium_infection_and_pathology_among_school_aged_children_in_Mali_ L2 - https://www.cambridge.org/core/product/identifier/S0031182008000486/type/journal_article DB - PRIME DP - Unbound Medicine ER -