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Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease.
Nutr Metab Cardiovasc Dis 2009; 19(9):654-9NM

Abstract

BACKGROUND AND AIMS

Patients with chronic obstructive pulmonary disease (COPD) are at increased atherothrombotic risk. Preliminary findings have suggested that COPD patients may have increased plasma total homocysteine (tHcy), a cardiovascular risk factor often caused by a poor B vitamin status, but plasma levels of such vitamins were not measured. The aim of this study was to investigate hyperhomocysteinaemia in COPD and to determine whether it may be secondary to poor plasma concentrations of B vitamins.

METHODS AND RESULTS

We performed a case-control, cross-sectional study of 42 patients with COPD and 29 control subjects. Folate, vitamin B12, vitamin B6, tHcy, renal function, C-reactive protein, blood gases and lipids were measured in patients and controls. COPD patients had higher plasma tHcy (median: 13.9mumol/l, interquantile range [IQR]: 12.1-18.5 versus 11.5, IQR: 10.1-14, p=0.002) and lower circulating folate (median: 2.5ng/ml, IQR: 1.2-3.3 versus 2.8, IQR: 2.1-4 of controls, p=0.03) than controls had. Compared to the control group, COPD was associated with higher tHcy concentrations also after adjusting for smoking, heart failure, renal function and C-reactive protein with logistic regression analysis (OR 1.36, 95% CI 1.06-1.72, p=0.01). In the COPD group, low levels of folate (beta=-0.27, p=0.02) and vitamin B12 (beta=-0.24, p=0.04), and hypertriglyceridaemia (beta=0.580, p<0.0001) were independent predictors of the presence of high tHcy concentrations in a multiple linear regression model (adjusted R(2)=0.522).

CONCLUSION

COPD patients have a poor B vitamin status and, as a consequence, increased tHcy. These abnormalities may contribute to the COPD-related atherothrombotic risk.

Authors+Show Affiliations

Unit of Respiratory Diseases, Division of Internal Medicine, Leopoldo Parodi Delfino Hospital, ASL Roma G, Colleferro (Rome), Italy. filippo.fimognari@virgilio.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19282159

Citation

Fimognari, F L., et al. "Hyperhomocysteinaemia and Poor Vitamin B Status in Chronic Obstructive Pulmonary Disease." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 9, 2009, pp. 654-9.
Fimognari FL, Loffredo L, Di Simone S, et al. Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease. Nutr Metab Cardiovasc Dis. 2009;19(9):654-9.
Fimognari, F. L., Loffredo, L., Di Simone, S., Sampietro, F., Pastorelli, R., Monaldo, M., ... D'Angelo, A. (2009). Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(9), pp. 654-9. doi:10.1016/j.numecd.2008.12.006.
Fimognari FL, et al. Hyperhomocysteinaemia and Poor Vitamin B Status in Chronic Obstructive Pulmonary Disease. Nutr Metab Cardiovasc Dis. 2009;19(9):654-9. PubMed PMID: 19282159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease. AU - Fimognari,F L, AU - Loffredo,L, AU - Di Simone,S, AU - Sampietro,F, AU - Pastorelli,R, AU - Monaldo,M, AU - Violi,F, AU - D'Angelo,A, Y1 - 2009/03/17/ PY - 2008/08/12/received PY - 2008/10/31/revised PY - 2008/12/05/accepted PY - 2009/3/14/entrez PY - 2009/3/14/pubmed PY - 2010/1/26/medline SP - 654 EP - 9 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 9 N2 - BACKGROUND AND AIMS: Patients with chronic obstructive pulmonary disease (COPD) are at increased atherothrombotic risk. Preliminary findings have suggested that COPD patients may have increased plasma total homocysteine (tHcy), a cardiovascular risk factor often caused by a poor B vitamin status, but plasma levels of such vitamins were not measured. The aim of this study was to investigate hyperhomocysteinaemia in COPD and to determine whether it may be secondary to poor plasma concentrations of B vitamins. METHODS AND RESULTS: We performed a case-control, cross-sectional study of 42 patients with COPD and 29 control subjects. Folate, vitamin B12, vitamin B6, tHcy, renal function, C-reactive protein, blood gases and lipids were measured in patients and controls. COPD patients had higher plasma tHcy (median: 13.9mumol/l, interquantile range [IQR]: 12.1-18.5 versus 11.5, IQR: 10.1-14, p=0.002) and lower circulating folate (median: 2.5ng/ml, IQR: 1.2-3.3 versus 2.8, IQR: 2.1-4 of controls, p=0.03) than controls had. Compared to the control group, COPD was associated with higher tHcy concentrations also after adjusting for smoking, heart failure, renal function and C-reactive protein with logistic regression analysis (OR 1.36, 95% CI 1.06-1.72, p=0.01). In the COPD group, low levels of folate (beta=-0.27, p=0.02) and vitamin B12 (beta=-0.24, p=0.04), and hypertriglyceridaemia (beta=0.580, p<0.0001) were independent predictors of the presence of high tHcy concentrations in a multiple linear regression model (adjusted R(2)=0.522). CONCLUSION: COPD patients have a poor B vitamin status and, as a consequence, increased tHcy. These abnormalities may contribute to the COPD-related atherothrombotic risk. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19282159/Hyperhomocysteinaemia_and_poor_vitamin_B_status_in_chronic_obstructive_pulmonary_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00254-8 DB - PRIME DP - Unbound Medicine ER -