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Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization.
Bioorg Med Chem. 2009 Apr 01; 17(7):2718-23.BM

Abstract

The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.

Authors+Show Affiliations

Departamento de Farmácia, Universidade Federal do Paraná, Av. Lothario Meissner, 632, Curitiba, PR 80210-170, Brazil. acasbahr@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19282187

Citation

Asbahr, Ana Carolina C., et al. "Binary and Ternary Inclusion Complexes of Finasteride in HPbetaCD and Polymers: Preparation and Characterization." Bioorganic & Medicinal Chemistry, vol. 17, no. 7, 2009, pp. 2718-23.
Asbahr AC, Franco L, Barison A, et al. Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization. Bioorg Med Chem. 2009;17(7):2718-23.
Asbahr, A. C., Franco, L., Barison, A., Silva, C. W., Ferraz, H. G., & Rodrigues, L. N. (2009). Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization. Bioorganic & Medicinal Chemistry, 17(7), 2718-23. https://doi.org/10.1016/j.bmc.2009.02.044
Asbahr AC, et al. Binary and Ternary Inclusion Complexes of Finasteride in HPbetaCD and Polymers: Preparation and Characterization. Bioorg Med Chem. 2009 Apr 1;17(7):2718-23. PubMed PMID: 19282187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization. AU - Asbahr,Ana Carolina C, AU - Franco,Luzia, AU - Barison,Andersson, AU - Silva,Caroline W P, AU - Ferraz,Humberto G, AU - Rodrigues,Letícia N C, Y1 - 2009/02/26/ PY - 2008/12/08/received PY - 2009/02/15/revised PY - 2009/02/20/accepted PY - 2009/3/14/entrez PY - 2009/3/14/pubmed PY - 2009/6/13/medline SP - 2718 EP - 23 JF - Bioorganic & medicinal chemistry JO - Bioorg Med Chem VL - 17 IS - 7 N2 - The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/19282187/Binary_and_ternary_inclusion_complexes_of_finasteride_in_HPbetaCD_and_polymers:_preparation_and_characterization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(09)00196-5 DB - PRIME DP - Unbound Medicine ER -