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Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization.
Bioorg Med Chem. 2009 Apr 01; 17(7):2718-23.BM

Abstract

The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.

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Authors+Show Affiliations

Asbahr AC
Departamento de Farmácia, Universidade Federal do Paraná, Av. Lothario Meissner, 632, Curitiba, PR 80210-170, Brazil. acasbahr@hotmail.com
Franco L
No affiliation info available
Barison A
No affiliation info available
Silva CW
No affiliation info available
Ferraz HG
No affiliation info available
Rodrigues LN
No affiliation info available

MeSH

2-Hydroxypropyl-beta-cyclodextrinCalorimetry, Differential ScanningChitosanFinasterideFreeze DryingMagnetic Resonance SpectroscopyPolymersPovidoneSolubilityX-Ray Diffractionbeta-Cyclodextrins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19282187

Citation

Asbahr, Ana Carolina C., et al. "Binary and Ternary Inclusion Complexes of Finasteride in HPbetaCD and Polymers: Preparation and Characterization." Bioorganic & Medicinal Chemistry, vol. 17, no. 7, 2009, pp. 2718-23.
Asbahr AC, Franco L, Barison A, et al. Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization. Bioorg Med Chem. 2009;17(7):2718-23.
Asbahr, A. C., Franco, L., Barison, A., Silva, C. W., Ferraz, H. G., & Rodrigues, L. N. (2009). Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization. Bioorganic & Medicinal Chemistry, 17(7), 2718-23. https://doi.org/10.1016/j.bmc.2009.02.044
Asbahr AC, et al. Binary and Ternary Inclusion Complexes of Finasteride in HPbetaCD and Polymers: Preparation and Characterization. Bioorg Med Chem. 2009 Apr 1;17(7):2718-23. PubMed PMID: 19282187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization. AU - Asbahr,Ana Carolina C, AU - Franco,Luzia, AU - Barison,Andersson, AU - Silva,Caroline W P, AU - Ferraz,Humberto G, AU - Rodrigues,Letícia N C, Y1 - 2009/02/26/ PY - 2008/12/08/received PY - 2009/02/15/revised PY - 2009/02/20/accepted PY - 2009/3/14/entrez PY - 2009/3/14/pubmed PY - 2009/6/13/medline SP - 2718 EP - 23 JF - Bioorganic & medicinal chemistry JO - Bioorg Med Chem VL - 17 IS - 7 N2 - The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/19282187/Binary_and_ternary_inclusion_complexes_of_finasteride_in_HPbetaCD_and_polymers:_preparation_and_characterization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(09)00196-5 DB - PRIME DP - Unbound Medicine ER -