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Airway smooth muscle thickness in asthma is related to severity but not duration of asthma.
Eur Respir J. 2009 Nov; 34(5):1040-5.ER

Abstract

Asthma is characterised by an increased airway smooth muscle (ASM) area (ASM(area)) within the airway wall. The present study examined the relationship of factors including severity and duration of asthma to ASM(area). The perimeter of the basement membrane (PBM) and ASM(area) were measured on transverse sections of large and small airways from post mortem cases of fatal (n = 107) and nonfatal asthma (n = 37) and from control subjects (n = 69). The thickness of ASM (ASM(area)/PBM) was compared between asthma groups using multivariate linear regression. When all airways were considered together, ASM(area)/PBM (in millimetres) was increased in nonfatal (median 0.04; interquartile range 0.013-0.051; p = 0.034) and fatal cases of asthma (0.048; 0.025-0.078; p<0.001) compared with controls (0.036; 0.024-0.042). Compared with cases of nonfatal asthma, ASM(area)/PBM was greater in cases of fatal asthma in large (p<0.001) and medium (p<0.001), but not small, airways. ASM(area)/PBM was not related to duration of asthma, age of onset of asthma, sex or smoking. No effect due to study centre, other than that due to sampling strategy, was found. The thickness of the ASM layer is increased in asthma and is related to the severity of asthma but not its duration.

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Authors+Show Affiliations

James AL
Dept of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Queen Elizabeth II Medical Centre, Nedlands, WA, Australia. alj@westnet.com.au
Bai TR
No affiliation info available
Mauad T
No affiliation info available
Abramson MJ
No affiliation info available
Dolhnikoff M
No affiliation info available
McKay KO
No affiliation info available
Maxwell PS
No affiliation info available
Elliot JG
No affiliation info available
Green FH
No affiliation info available

MeSH

AdolescentAdultAgedAsthmaBasement MembraneBronchiChildFemaleHumansMaleMiddle AgedMultivariate AnalysisMuscle, SmoothRespiratory SystemTreatment Outcome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19282340

Citation

James, A L., et al. "Airway Smooth Muscle Thickness in Asthma Is Related to Severity but Not Duration of Asthma." The European Respiratory Journal, vol. 34, no. 5, 2009, pp. 1040-5.
James AL, Bai TR, Mauad T, et al. Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. Eur Respir J. 2009;34(5):1040-5.
James, A. L., Bai, T. R., Mauad, T., Abramson, M. J., Dolhnikoff, M., McKay, K. O., Maxwell, P. S., Elliot, J. G., & Green, F. H. (2009). Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. The European Respiratory Journal, 34(5), 1040-5. https://doi.org/10.1183/09031936.00181608
James AL, et al. Airway Smooth Muscle Thickness in Asthma Is Related to Severity but Not Duration of Asthma. Eur Respir J. 2009;34(5):1040-5. PubMed PMID: 19282340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. AU - James,A L, AU - Bai,T R, AU - Mauad,T, AU - Abramson,M J, AU - Dolhnikoff,M, AU - McKay,K O, AU - Maxwell,P S, AU - Elliot,J G, AU - Green,F H, Y1 - 2009/03/12/ PY - 2009/3/14/entrez PY - 2009/3/14/pubmed PY - 2010/3/17/medline SP - 1040 EP - 5 JF - The European respiratory journal JO - Eur Respir J VL - 34 IS - 5 N2 - Asthma is characterised by an increased airway smooth muscle (ASM) area (ASM(area)) within the airway wall. The present study examined the relationship of factors including severity and duration of asthma to ASM(area). The perimeter of the basement membrane (PBM) and ASM(area) were measured on transverse sections of large and small airways from post mortem cases of fatal (n = 107) and nonfatal asthma (n = 37) and from control subjects (n = 69). The thickness of ASM (ASM(area)/PBM) was compared between asthma groups using multivariate linear regression. When all airways were considered together, ASM(area)/PBM (in millimetres) was increased in nonfatal (median 0.04; interquartile range 0.013-0.051; p = 0.034) and fatal cases of asthma (0.048; 0.025-0.078; p<0.001) compared with controls (0.036; 0.024-0.042). Compared with cases of nonfatal asthma, ASM(area)/PBM was greater in cases of fatal asthma in large (p<0.001) and medium (p<0.001), but not small, airways. ASM(area)/PBM was not related to duration of asthma, age of onset of asthma, sex or smoking. No effect due to study centre, other than that due to sampling strategy, was found. The thickness of the ASM layer is increased in asthma and is related to the severity of asthma but not its duration. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/19282340/Airway_smooth_muscle_thickness_in_asthma_is_related_to_severity_but_not_duration_of_asthma_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&amp;pmid=19282340 DB - PRIME DP - Unbound Medicine ER -