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Effect of L-arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis.
Amino Acids. 2010 Jan; 38(1):339-45.AA

Abstract

Cholestatic encephalopathy results from accumulation of unconjugated bilirubin and hydrophobic bile acids in the brain. The aim of this study was to determine disturbances of polyamine metabolism in the brains of rats with experimental extrahepatic cholestasis and the effects of L-arginine administration. Wister rats were divided into groups: I: sham-operated, II: rats treated with L-arginine, III: animals with bile-duct ligation (BDL), and IV: cholestatic-BDL rats treated with L-arginine. Increased plasma gamma-glutamyltransferase and alkaline phosphatase activity and increased bile-acids and bilirubin levels in BDL rats were reduced by administration of L-arginine (P < 0.001). Cholestasis increased the brain's putrescine (P < 0.001) and decreased spermidine and spermine concentration (P < 0.05). The activity of polyamine oxidase was increased (P < 0.001) and diamine oxidase was decreased (P < 0.001) in the brains of BDL rats. Cholestasis increased the activity of arginase (P < 0.05) and decreased the level of citrulline (P < 0.001). Administration of L-arginine in BDL rats prevents metabolic disorders of polyamines and establishes a neuroprotective role in the brain during cholestasis.

Authors+Show Affiliations

Institute of Biochemistry, Medical Faculty in Nis, , Nis, Serbia. soko@medfak.ni.ac.yuNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19283445

Citation

Sokolovic, Dusan, et al. "Effect of L-arginine On Metabolism of Polyamines in Rat's Brain With Extrahepatic Cholestasis." Amino Acids, vol. 38, no. 1, 2010, pp. 339-45.
Sokolovic D, Bjelakovic G, Nikolic J, et al. Effect of L-arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. Amino Acids. 2010;38(1):339-45.
Sokolovic, D., Bjelakovic, G., Nikolic, J., Djindjic, B., Pavlovic, D., Kocic, G., Stojanovic, I., & Pavlovic, V. (2010). Effect of L-arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. Amino Acids, 38(1), 339-45. https://doi.org/10.1007/s00726-009-0266-3
Sokolovic D, et al. Effect of L-arginine On Metabolism of Polyamines in Rat's Brain With Extrahepatic Cholestasis. Amino Acids. 2010;38(1):339-45. PubMed PMID: 19283445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of L-arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. AU - Sokolovic,Dusan, AU - Bjelakovic,Gordana, AU - Nikolic,Jelenka, AU - Djindjic,Boris, AU - Pavlovic,Dusica, AU - Kocic,Gordana, AU - Stojanovic,Ivana, AU - Pavlovic,Voja, Y1 - 2009/03/13/ PY - 2007/10/17/received PY - 2008/01/09/accepted PY - 2009/3/14/entrez PY - 2009/3/14/pubmed PY - 2010/4/3/medline SP - 339 EP - 45 JF - Amino acids JO - Amino Acids VL - 38 IS - 1 N2 - Cholestatic encephalopathy results from accumulation of unconjugated bilirubin and hydrophobic bile acids in the brain. The aim of this study was to determine disturbances of polyamine metabolism in the brains of rats with experimental extrahepatic cholestasis and the effects of L-arginine administration. Wister rats were divided into groups: I: sham-operated, II: rats treated with L-arginine, III: animals with bile-duct ligation (BDL), and IV: cholestatic-BDL rats treated with L-arginine. Increased plasma gamma-glutamyltransferase and alkaline phosphatase activity and increased bile-acids and bilirubin levels in BDL rats were reduced by administration of L-arginine (P < 0.001). Cholestasis increased the brain's putrescine (P < 0.001) and decreased spermidine and spermine concentration (P < 0.05). The activity of polyamine oxidase was increased (P < 0.001) and diamine oxidase was decreased (P < 0.001) in the brains of BDL rats. Cholestasis increased the activity of arginase (P < 0.05) and decreased the level of citrulline (P < 0.001). Administration of L-arginine in BDL rats prevents metabolic disorders of polyamines and establishes a neuroprotective role in the brain during cholestasis. SN - 1438-2199 UR - https://www.unboundmedicine.com/medline/citation/19283445/Effect_of_L_arginine_on_metabolism_of_polyamines_in_rat's_brain_with_extrahepatic_cholestasis_ L2 - https://dx.doi.org/10.1007/s00726-009-0266-3 DB - PRIME DP - Unbound Medicine ER -