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Does valerian improve sleepiness and symptom severity in people with restless legs syndrome?
Altern Ther Health Med 2009 Mar-Apr; 15(2):22-8AT

Abstract

OBJECTIVE

To compare the effects of 800 mg of valerian with a placebo on sleep quality and symptom severity in people with restless legs syndrome (RLS).

METHODS

A prospective, triple-blinded, randomized, placebo-controlled, parallel design was used to compare the efficacy of valerian with placebo on sleep quality and symptom severity in patients with RLS. Thirty-seven participants were randomly assigned to receive 800 mg of valerian or placebo for 8 weeks. The primary outcome of sleep was sleep quality with secondary outcomes including sleepiness and RLS symptom severity.

RESULTS

Data were collected at baseline and 8 weeks comparing use of valerian and placebo on sleep disturbances (Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale) and severity of RLS symptoms (International RLS Symptom Severity Scale) from 37 participants aged 36 to 65 years. Both groups reported improvement in RLS symptom severity and sleep. In a nested analysis comparing sleepy vs nonsleepy participants who received 800 mg ofvalerian (n=17), significant differences before and after treatment were found in sleepiness (P=.01) and RLS symptoms (P=.02). A strong positive association between changes in sleepiness and RLS symptom severity was found (P=.006).

CONCLUSIONS

The results of this study suggest that the use of 800 mg of valerian for 8 weeks improves symptoms of RLS and decreases daytime sleepiness in patients that report an Epworth Sleepiness Scale (ESS) score of 10 or greater. Valerian may be an alternative treatment for the symptom management ofRLS with positive health outcomes and improved quality of life.

Authors+Show Affiliations

University of Pennsylvania School of Nursing, Philadelphia, PA, USA.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19284179

Citation

Cuellar, Norma G., and Sarah J. Ratcliffe. "Does Valerian Improve Sleepiness and Symptom Severity in People With Restless Legs Syndrome?" Alternative Therapies in Health and Medicine, vol. 15, no. 2, 2009, pp. 22-8.
Cuellar NG, Ratcliffe SJ. Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? Altern Ther Health Med. 2009;15(2):22-8.
Cuellar, N. G., & Ratcliffe, S. J. (2009). Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? Alternative Therapies in Health and Medicine, 15(2), pp. 22-8.
Cuellar NG, Ratcliffe SJ. Does Valerian Improve Sleepiness and Symptom Severity in People With Restless Legs Syndrome. Altern Ther Health Med. 2009;15(2):22-8. PubMed PMID: 19284179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? AU - Cuellar,Norma G, AU - Ratcliffe,Sarah J, PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/5/15/medline SP - 22 EP - 8 JF - Alternative therapies in health and medicine JO - Altern Ther Health Med VL - 15 IS - 2 N2 - OBJECTIVE: To compare the effects of 800 mg of valerian with a placebo on sleep quality and symptom severity in people with restless legs syndrome (RLS). METHODS: A prospective, triple-blinded, randomized, placebo-controlled, parallel design was used to compare the efficacy of valerian with placebo on sleep quality and symptom severity in patients with RLS. Thirty-seven participants were randomly assigned to receive 800 mg of valerian or placebo for 8 weeks. The primary outcome of sleep was sleep quality with secondary outcomes including sleepiness and RLS symptom severity. RESULTS: Data were collected at baseline and 8 weeks comparing use of valerian and placebo on sleep disturbances (Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale) and severity of RLS symptoms (International RLS Symptom Severity Scale) from 37 participants aged 36 to 65 years. Both groups reported improvement in RLS symptom severity and sleep. In a nested analysis comparing sleepy vs nonsleepy participants who received 800 mg ofvalerian (n=17), significant differences before and after treatment were found in sleepiness (P=.01) and RLS symptoms (P=.02). A strong positive association between changes in sleepiness and RLS symptom severity was found (P=.006). CONCLUSIONS: The results of this study suggest that the use of 800 mg of valerian for 8 weeks improves symptoms of RLS and decreases daytime sleepiness in patients that report an Epworth Sleepiness Scale (ESS) score of 10 or greater. Valerian may be an alternative treatment for the symptom management ofRLS with positive health outcomes and improved quality of life. SN - 1078-6791 UR - https://www.unboundmedicine.com/medline/citation/19284179/Does_valerian_improve_sleepiness_and_symptom_severity_in_people_with_restless_legs_syndrome L2 - http://www.diseaseinfosearch.org/result/6228 DB - PRIME DP - Unbound Medicine ER -