Tags

Type your tag names separated by a space and hit enter

Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas.
J Infect Dis. 2009 Apr 15; 199(8):1121-7.JI

Abstract

BACKGROUND

Markers of Epstein-Barr virus (EBV) infection include anti-viral capsid antigen (VCA) immunoglobulin (Ig) G. High anti-VCA titers are associated with EBV-related lymphoproliferation, such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL).

METHODS

Intrafamilial correlations of anti-VCA IgG levels were studied in 3 settings: 127 families recruited through patients with HL in France (population A), 31 families recruited through patients with BL in Uganda (population B), and 74 large families from a general population in Cameroon (population C). Titers were determined by enzyme-linked immunosorbent assay (populations A and C) or by immunofluorescence analysis (population B).

RESULTS

In populations A and B, the anti-VCA IgG titers of the relatives of patients with HL or BL increased significantly (P = .01 and P < .001, respectively) with those of the index case patient. In all 3 populations, anti-VCA IgG titers were significantly correlated (P < .001 for A, P = .002 for B, and P < .001 for C) between genetically related individuals (father-offspring, mother-offspring, and sibling-sibling) but not between spouses. Similar results were obtained for population A after adjustment for total IgG levels. In all cases, the pattern of correlations was consistent with a polygenic model, with heritability ranging from 0.32 to 0.48.

CONCLUSION

These results provide evidence for the genetic control of anti-VCA IgG titers and pave the way for identification of the loci involved.

Authors+Show Affiliations

Laboratoire de Génétique Humaine des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale, Unité 550, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19284285

Citation

Besson, Caroline, et al. "Strong Correlations of Anti-viral Capsid Antigen Antibody Levels in First-degree Relatives From Families With Epstein-Barr Virus-related Lymphomas." The Journal of Infectious Diseases, vol. 199, no. 8, 2009, pp. 1121-7.
Besson C, Amiel C, Le-Pendeven C, et al. Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas. J Infect Dis. 2009;199(8):1121-7.
Besson, C., Amiel, C., Le-Pendeven, C., Plancoulaine, S., Bonnardel, C., Ranque, B., Abbed, K., Brice, P., Fermé, C., Carde, P., Hermine, O., Raphael, M., Bresson, J. L., Nicolas, J. C., Gessain, A., Dethe, G., & Abel, L. (2009). Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas. The Journal of Infectious Diseases, 199(8), 1121-7. https://doi.org/10.1086/597424
Besson C, et al. Strong Correlations of Anti-viral Capsid Antigen Antibody Levels in First-degree Relatives From Families With Epstein-Barr Virus-related Lymphomas. J Infect Dis. 2009 Apr 15;199(8):1121-7. PubMed PMID: 19284285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas. AU - Besson,Caroline, AU - Amiel,Corinne, AU - Le-Pendeven,Catherine, AU - Plancoulaine,Sabine, AU - Bonnardel,Colette, AU - Ranque,Brigitte, AU - Abbed,Karim, AU - Brice,Pauline, AU - Fermé,Christophe, AU - Carde,Patrice, AU - Hermine,Olivier, AU - Raphael,Martine, AU - Bresson,Jean-Louis, AU - Nicolas,Jean-Claude, AU - Gessain,Antoine, AU - Dethe,Guy, AU - Abel,Laurent, PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/5/29/medline SP - 1121 EP - 7 JF - The Journal of infectious diseases JO - J Infect Dis VL - 199 IS - 8 N2 - BACKGROUND: Markers of Epstein-Barr virus (EBV) infection include anti-viral capsid antigen (VCA) immunoglobulin (Ig) G. High anti-VCA titers are associated with EBV-related lymphoproliferation, such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL). METHODS: Intrafamilial correlations of anti-VCA IgG levels were studied in 3 settings: 127 families recruited through patients with HL in France (population A), 31 families recruited through patients with BL in Uganda (population B), and 74 large families from a general population in Cameroon (population C). Titers were determined by enzyme-linked immunosorbent assay (populations A and C) or by immunofluorescence analysis (population B). RESULTS: In populations A and B, the anti-VCA IgG titers of the relatives of patients with HL or BL increased significantly (P = .01 and P < .001, respectively) with those of the index case patient. In all 3 populations, anti-VCA IgG titers were significantly correlated (P < .001 for A, P = .002 for B, and P < .001 for C) between genetically related individuals (father-offspring, mother-offspring, and sibling-sibling) but not between spouses. Similar results were obtained for population A after adjustment for total IgG levels. In all cases, the pattern of correlations was consistent with a polygenic model, with heritability ranging from 0.32 to 0.48. CONCLUSION: These results provide evidence for the genetic control of anti-VCA IgG titers and pave the way for identification of the loci involved. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/19284285/Strong_correlations_of_anti_viral_capsid_antigen_antibody_levels_in_first_degree_relatives_from_families_with_Epstein_Barr_virus_related_lymphomas_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/597424 DB - PRIME DP - Unbound Medicine ER -