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Association of leukocyte count with varying degrees of glucose intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26).
Metab Syndr Relat Disord. 2009 Jun; 7(3):205-10.MS

Abstract

OBJECTIVE

This study assessed the association of leukocyte count with different grades of glucose intolerance in Asian Indian subjects.

METHODS

Three groups of subjects were recruited from the Chennai Urban Rural Epidemiology Study (CURES), a population-based study, representative of Chennai (formerly Madras), a city in southern India. Group 1 represented normal glucose tolerance (NGT) (n = 840), group 2 included impaired glucose tolerance (IGT) (n = 180), and group 3 included type 2 diabetes (n = 1170). Anthropometric measurements including weight, height, and waist measurements were obtained using standardized techniques. Leukocyte count was measured by an automated flow cytometry instrument (Sysmex SF-3000, Japan). Fasting insulin was measured by enzyme-linked immunosorbent assay and insulin resistance was calculated using the homeostasis model assessment (HOMA-IR).

RESULTS

Subjects with diabetes (8.0 +/- 1.5 x 10(3)/microL) and IGT (7.9 +/- 1.3 x 10(3)/microL) had a significantly higher mean leukocyte count compared to the NGT group (7.4 +/- 1.5 x 10(3)/microL) (P < 0.001). Leukocyte count was significantly increased in NGT subjects with insulin resistance (IR) as measured by HOMA-IR (7.5 +/- 1.5 x 10(3)/microL; P < 0.001) compared to NGT subjects without IR (7.0 +/- 1.4 x 10(3)/microL). Regression analysis showed that there was a linear increase in mean leukocyte count with increasing severity of glucose intolerance, even after adjusting for age, waist circumference, and HOMA-IR.

CONCLUSIONS

Among Asian Indians who are known to have high risk of premature coronary artery disease and diabetes, a significant association exists between leukocyte count and glucose intolerance.

Authors+Show Affiliations

Dr. Mohan's Diabetes Specialities Centre and Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Disease Prevention and Control, Gopalapuram, Chennai, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19284318

Citation

Gokulakrishnan, Kuppan, et al. "Association of Leukocyte Count With Varying Degrees of Glucose Intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26)." Metabolic Syndrome and Related Disorders, vol. 7, no. 3, 2009, pp. 205-10.
Gokulakrishnan K, Deepa R, Sampathkumar R, et al. Association of leukocyte count with varying degrees of glucose intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26). Metab Syndr Relat Disord. 2009;7(3):205-10.
Gokulakrishnan, K., Deepa, R., Sampathkumar, R., Balasubramanyam, M., & Mohan, V. (2009). Association of leukocyte count with varying degrees of glucose intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26). Metabolic Syndrome and Related Disorders, 7(3), 205-10. https://doi.org/10.1089/met.2008.0024
Gokulakrishnan K, et al. Association of Leukocyte Count With Varying Degrees of Glucose Intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26). Metab Syndr Relat Disord. 2009;7(3):205-10. PubMed PMID: 19284318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of leukocyte count with varying degrees of glucose intolerance in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-26). AU - Gokulakrishnan,Kuppan, AU - Deepa,Raj, AU - Sampathkumar,Rangasamy, AU - Balasubramanyam,Muthuswamy, AU - Mohan,Viswanathan, PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/8/15/medline SP - 205 EP - 10 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 7 IS - 3 N2 - OBJECTIVE: This study assessed the association of leukocyte count with different grades of glucose intolerance in Asian Indian subjects. METHODS: Three groups of subjects were recruited from the Chennai Urban Rural Epidemiology Study (CURES), a population-based study, representative of Chennai (formerly Madras), a city in southern India. Group 1 represented normal glucose tolerance (NGT) (n = 840), group 2 included impaired glucose tolerance (IGT) (n = 180), and group 3 included type 2 diabetes (n = 1170). Anthropometric measurements including weight, height, and waist measurements were obtained using standardized techniques. Leukocyte count was measured by an automated flow cytometry instrument (Sysmex SF-3000, Japan). Fasting insulin was measured by enzyme-linked immunosorbent assay and insulin resistance was calculated using the homeostasis model assessment (HOMA-IR). RESULTS: Subjects with diabetes (8.0 +/- 1.5 x 10(3)/microL) and IGT (7.9 +/- 1.3 x 10(3)/microL) had a significantly higher mean leukocyte count compared to the NGT group (7.4 +/- 1.5 x 10(3)/microL) (P < 0.001). Leukocyte count was significantly increased in NGT subjects with insulin resistance (IR) as measured by HOMA-IR (7.5 +/- 1.5 x 10(3)/microL; P < 0.001) compared to NGT subjects without IR (7.0 +/- 1.4 x 10(3)/microL). Regression analysis showed that there was a linear increase in mean leukocyte count with increasing severity of glucose intolerance, even after adjusting for age, waist circumference, and HOMA-IR. CONCLUSIONS: Among Asian Indians who are known to have high risk of premature coronary artery disease and diabetes, a significant association exists between leukocyte count and glucose intolerance. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/19284318/Association_of_leukocyte_count_with_varying_degrees_of_glucose_intolerance_in_Asian_Indians:_the_Chennai_Urban_Rural_Epidemiology_Study__CURES_26__ DB - PRIME DP - Unbound Medicine ER -