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Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients--an observational study.
BMC Nephrol. 2009 Mar 12; 10:8.BN

Abstract

BACKGROUND

Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffness, endothelial dysfunction and elevated oxidative stress and inflammation. The aims of this study are to investigate the effects of peritoneal and hemodialysis on arterial stiffness, vascular function, myocardial structure and function, oxidative stress and inflammation in incident patients with end stage kidney disease.

METHODS

This is an observational study. Eighty stage five CKD patients will be enrolled and followed for one-year. Primary outcome measures will be changes in 1) arterial stiffness measured by aortic pulse wave velocity, 2) oxidative stress assessed by plasma F2 isoprostanes and 3) inflammation measured by plasma pentraxin-3. Secondary outcomes will include additional measures of oxidative stress and inflammation, changes in vascular function assessed using the brachial artery reactivity technique, carotid artery intimal medial thickness, augmentation index and trans thoracic echocardiography to assess left ventricular geometry, and systolic and diastolic function. Patients will undergo these measures at baseline (6-8 weeks prior to starting dialysis therapy), then at six and 12 months after starting dialysis.

DISCUSSION

The results of this study may guide the choice of dialysis modality in the first year of treatment. It may also lead to a larger study prospectively assessing the effect of dialysis modality on cardiovascular morbidity and mortality.

TRIAL REGISTRATION

ACTRN12609000049279.

Authors+Show Affiliations

Renal Research, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. rfassett@mac.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19284599

Citation

Fassett, Robert G., et al. "Comparison of Markers of Oxidative Stress, Inflammation and Arterial Stiffness Between Incident Hemodialysis and Peritoneal Dialysis Patients--an Observational Study." BMC Nephrology, vol. 10, 2009, p. 8.
Fassett RG, Driver R, Healy H, et al. Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients--an observational study. BMC Nephrol. 2009;10:8.
Fassett, R. G., Driver, R., Healy, H., Ranganathan, D., Ratanjee, S., Robertson, I. K., Geraghty, D. P., Sharman, J. E., & Coombes, J. S. (2009). Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients--an observational study. BMC Nephrology, 10, 8. https://doi.org/10.1186/1471-2369-10-8
Fassett RG, et al. Comparison of Markers of Oxidative Stress, Inflammation and Arterial Stiffness Between Incident Hemodialysis and Peritoneal Dialysis Patients--an Observational Study. BMC Nephrol. 2009 Mar 12;10:8. PubMed PMID: 19284599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients--an observational study. AU - Fassett,Robert G, AU - Driver,Ritza, AU - Healy,Helen, AU - Ranganathan,Dwarakanathan, AU - Ratanjee,Sharad, AU - Robertson,Iain K, AU - Geraghty,Dominic P, AU - Sharman,James E, AU - Coombes,Jeff S, Y1 - 2009/03/12/ PY - 2009/02/12/received PY - 2009/03/12/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/5/30/medline SP - 8 EP - 8 JF - BMC nephrology JO - BMC Nephrol VL - 10 N2 - BACKGROUND: Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffness, endothelial dysfunction and elevated oxidative stress and inflammation. The aims of this study are to investigate the effects of peritoneal and hemodialysis on arterial stiffness, vascular function, myocardial structure and function, oxidative stress and inflammation in incident patients with end stage kidney disease. METHODS: This is an observational study. Eighty stage five CKD patients will be enrolled and followed for one-year. Primary outcome measures will be changes in 1) arterial stiffness measured by aortic pulse wave velocity, 2) oxidative stress assessed by plasma F2 isoprostanes and 3) inflammation measured by plasma pentraxin-3. Secondary outcomes will include additional measures of oxidative stress and inflammation, changes in vascular function assessed using the brachial artery reactivity technique, carotid artery intimal medial thickness, augmentation index and trans thoracic echocardiography to assess left ventricular geometry, and systolic and diastolic function. Patients will undergo these measures at baseline (6-8 weeks prior to starting dialysis therapy), then at six and 12 months after starting dialysis. DISCUSSION: The results of this study may guide the choice of dialysis modality in the first year of treatment. It may also lead to a larger study prospectively assessing the effect of dialysis modality on cardiovascular morbidity and mortality. TRIAL REGISTRATION: ACTRN12609000049279. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/19284599/Comparison_of_markers_of_oxidative_stress_inflammation_and_arterial_stiffness_between_incident_hemodialysis_and_peritoneal_dialysis_patients__an_observational_study_ L2 - https://www.biomedcentral.com/1471-2369/10/8 DB - PRIME DP - Unbound Medicine ER -