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Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex.
Brain Res. 2009 May 07; 1269:40-6.BR

Abstract

It is known that psychostimulants stimulate dopamine transmission in the nucleus accumbens. In the present study, we examined the effects of systemically administered beta-phenylethylamine (beta-PEA), a psychomotor-stimulating trace amine, on dopamine concentrations in the nucleus accumbens and prefrontal cortex in freely moving rats, using an in vivo microdialysis technique. Intraperitoneal administration of beta-PEA (12.5 and 25 mg/kg) significantly increased extracellular dopamine levels in the nucleus accumbens shell. The observed increase in the dopamine concentration in nucleus accumbens shell dialysate after intraperitoneal administration of 25 mg/kg beta-PEA was inhibited by pre-treatment with a dopamine uptake inhibitor, GBR12909 (10 mg/kg, i.p.). In contrast, beta-PEA (25 mg/kg, i.p.) did not affect dopamine release in the nucleus accumbens core. Although a high dose of beta-PEA (50 mg/kg) significantly increased dopamine levels in the nucleus accumbens core, the dopamine increasing effect of beta-PEA was more potent in the nucleus accumbens shell. Systemic administration of 12.5 and 25 mg/kg beta-PEA also increased extracellular dopamine levels in the prefrontal cortex of rats. However, systemic 25 mg/kg beta-PEA-induced increases in extracellular dopamine levels were not blocked by GBR12909 within the prefrontal cortex. These results suggest that beta-PEA has a greater effect in the shell than in the core and low-dose beta-PEA stimulates dopamine release in the nucleus accumbens shell through uptake by a dopamine transporter. Similarly, beta-PEA increased extracellular dopamine levels in the prefrontal cortex. Thus, beta-PEA may increase extracellular dopamine concentrations in the mesocorticolimbic pathway.

Authors+Show Affiliations

Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-0042, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19285043

Citation

Murata, Mikio, et al. "Effect of Beta-phenylethylamine On Extracellular Concentrations of Dopamine in the Nucleus Accumbens and Prefrontal Cortex." Brain Research, vol. 1269, 2009, pp. 40-6.
Murata M, Katagiri N, Ishida K, et al. Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex. Brain Res. 2009;1269:40-6.
Murata, M., Katagiri, N., Ishida, K., Abe, K., Ishikawa, M., Utsunomiya, I., Hoshi, K., Miyamoto, K., & Taguchi, K. (2009). Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex. Brain Research, 1269, 40-6. https://doi.org/10.1016/j.brainres.2009.03.002
Murata M, et al. Effect of Beta-phenylethylamine On Extracellular Concentrations of Dopamine in the Nucleus Accumbens and Prefrontal Cortex. Brain Res. 2009 May 7;1269:40-6. PubMed PMID: 19285043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex. AU - Murata,Mikio, AU - Katagiri,Nobuyuki, AU - Ishida,Kota, AU - Abe,Kenji, AU - Ishikawa,Masago, AU - Utsunomiya,Iku, AU - Hoshi,Keiko, AU - Miyamoto,Ken-ichi, AU - Taguchi,Kyoji, Y1 - 2009/03/11/ PY - 2008/08/11/received PY - 2009/03/02/revised PY - 2009/03/02/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/7/30/medline SP - 40 EP - 6 JF - Brain research JO - Brain Res VL - 1269 N2 - It is known that psychostimulants stimulate dopamine transmission in the nucleus accumbens. In the present study, we examined the effects of systemically administered beta-phenylethylamine (beta-PEA), a psychomotor-stimulating trace amine, on dopamine concentrations in the nucleus accumbens and prefrontal cortex in freely moving rats, using an in vivo microdialysis technique. Intraperitoneal administration of beta-PEA (12.5 and 25 mg/kg) significantly increased extracellular dopamine levels in the nucleus accumbens shell. The observed increase in the dopamine concentration in nucleus accumbens shell dialysate after intraperitoneal administration of 25 mg/kg beta-PEA was inhibited by pre-treatment with a dopamine uptake inhibitor, GBR12909 (10 mg/kg, i.p.). In contrast, beta-PEA (25 mg/kg, i.p.) did not affect dopamine release in the nucleus accumbens core. Although a high dose of beta-PEA (50 mg/kg) significantly increased dopamine levels in the nucleus accumbens core, the dopamine increasing effect of beta-PEA was more potent in the nucleus accumbens shell. Systemic administration of 12.5 and 25 mg/kg beta-PEA also increased extracellular dopamine levels in the prefrontal cortex of rats. However, systemic 25 mg/kg beta-PEA-induced increases in extracellular dopamine levels were not blocked by GBR12909 within the prefrontal cortex. These results suggest that beta-PEA has a greater effect in the shell than in the core and low-dose beta-PEA stimulates dopamine release in the nucleus accumbens shell through uptake by a dopamine transporter. Similarly, beta-PEA increased extracellular dopamine levels in the prefrontal cortex. Thus, beta-PEA may increase extracellular dopamine concentrations in the mesocorticolimbic pathway. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19285043/Effect_of_beta_phenylethylamine_on_extracellular_concentrations_of_dopamine_in_the_nucleus_accumbens_and_prefrontal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)00478-8 DB - PRIME DP - Unbound Medicine ER -