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A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma.
Nutr Res. 2009 Feb; 29(2):89-93.NR

Abstract

Nutritional support may play an important role in management of liver cirrhosis (LC) associated with unresectable hepatocellular carcinoma (HCC). Total protein and albumin deteriorate in patients with LC undergoing trans-arterial chemoembolization (TACE). Therefore, in this study, we examined the hypothesis that short-term administration of branched-chain amino acids (BCAA) will prevent a fall in total protein and albumin in the perioperative period. The subjects were 56 patients who underwent TACE for HCC between 2004 and 2005 at Nagasaki University Hospital. The patients were randomly placed in the BCAA group (n = 28) or a control group (n = 28). The patients in the BCAA group consumed a snack containing 50 g of BCAA once a day at 10:00 pm starting 1 day before TACE and continuing until 2 weeks after TACE. A comparison of baseline and end point data showed greater decreases in the concentrations of total protein, albumin, cholinesterase, and total cholesterol and in the red blood cell count in the control group compared to the BCAA group. Ammonia levels decreased in the BCAA group and increased in the control group. Our findings indicate that a BCAA supplement taken orally as a late evening snack prevents suppression of liver function by TACE in patients with LC complicated with HCC during the 2-week period after TACE.

Authors+Show Affiliations

The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan. shige-ygc@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19285598

Citation

Takeshita, Shigeyuki, et al. "A Snack Enriched With Oral Branched-chain Amino Acids Prevents a Fall in Albumin in Patients With Liver Cirrhosis Undergoing Chemoembolization for Hepatocellular Carcinoma." Nutrition Research (New York, N.Y.), vol. 29, no. 2, 2009, pp. 89-93.
Takeshita S, Ichikawa T, Nakao K, et al. A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma. Nutr Res. 2009;29(2):89-93.
Takeshita, S., Ichikawa, T., Nakao, K., Miyaaki, H., Shibata, H., Matsuzaki, T., Muraoka, T., Honda, T., Otani, M., Akiyama, M., Miuma, S., Ozawa, E., Fujimito, M., & Eguchi, K. (2009). A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma. Nutrition Research (New York, N.Y.), 29(2), 89-93. https://doi.org/10.1016/j.nutres.2008.12.005
Takeshita S, et al. A Snack Enriched With Oral Branched-chain Amino Acids Prevents a Fall in Albumin in Patients With Liver Cirrhosis Undergoing Chemoembolization for Hepatocellular Carcinoma. Nutr Res. 2009;29(2):89-93. PubMed PMID: 19285598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma. AU - Takeshita,Shigeyuki, AU - Ichikawa,Tatsuki, AU - Nakao,Kazuhiko, AU - Miyaaki,Hisamitsu, AU - Shibata,Hidetaka, AU - Matsuzaki,Toshihisa, AU - Muraoka,Toru, AU - Honda,Takuya, AU - Otani,Masashi, AU - Akiyama,Motohisa, AU - Miuma,Satoshi, AU - Ozawa,Esuke, AU - Fujimito,Masumi, AU - Eguchi,Katsumi, PY - 2008/11/16/received PY - 2008/12/16/revised PY - 2008/12/30/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/6/6/medline SP - 89 EP - 93 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 2 N2 - Nutritional support may play an important role in management of liver cirrhosis (LC) associated with unresectable hepatocellular carcinoma (HCC). Total protein and albumin deteriorate in patients with LC undergoing trans-arterial chemoembolization (TACE). Therefore, in this study, we examined the hypothesis that short-term administration of branched-chain amino acids (BCAA) will prevent a fall in total protein and albumin in the perioperative period. The subjects were 56 patients who underwent TACE for HCC between 2004 and 2005 at Nagasaki University Hospital. The patients were randomly placed in the BCAA group (n = 28) or a control group (n = 28). The patients in the BCAA group consumed a snack containing 50 g of BCAA once a day at 10:00 pm starting 1 day before TACE and continuing until 2 weeks after TACE. A comparison of baseline and end point data showed greater decreases in the concentrations of total protein, albumin, cholinesterase, and total cholesterol and in the red blood cell count in the control group compared to the BCAA group. Ammonia levels decreased in the BCAA group and increased in the control group. Our findings indicate that a BCAA supplement taken orally as a late evening snack prevents suppression of liver function by TACE in patients with LC complicated with HCC during the 2-week period after TACE. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19285598/A_snack_enriched_with_oral_branched_chain_amino_acids_prevents_a_fall_in_albumin_in_patients_with_liver_cirrhosis_undergoing_chemoembolization_for_hepatocellular_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00002-5 DB - PRIME DP - Unbound Medicine ER -