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Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir.
Int J Pediatr Otorhinolaryngol. 2009 May; 73(5):757-9.IJ

Abstract

BACKGROUND

Cephalosporins were found to be more effective than penicillins in the eradication of group A beta-hemolytic streptococcal (GABHS) from tonsillar tissues. This study investigated the effect of amoxicillin and cefdinir therapies on the rate of eradication of GABHS from the tonsils of children with acute pharyngo-tonsillitis (PT).

PATIENTS AND METHODS

Of 50 children suffering from PT 25 were treated with amoxicillin (40 mg/(kg d) or 250 mg every 8 h) and 25 with cefdinir (14 mg/(kg d) or 600 mg once a day) for 10 days. Pharyngo-tonsillar cultures were obtained from all children before treatment and on the 1st, 2nd, 3rd, 4th, 7th, and 12th days.

RESULTS

GABHS was eradicated more rapidly from children treated with cefdinir as compared to those receiving amoxicillin. A smaller number of patients with GABHS were found in those treated with cefdinir as compared to amoxicillin throughout the treatment period. Eradication of GABHS from 68% (8 of 25 patients) was noted in those treated with cefdinir after 2 days and those treated with amoxicillin after 4 days. The differences between the number of patients who had a bacteriological cure between those receiving cefdinir to those getting amoxicillin was statistical significant at day 4 (32% vs. 8%). At the end of therapy GABHS was recovered from 5 (20%) and 2 (8%) of the patients. The group that received cefdinir, had a more rapid reduction in fever on the first after initiation of therapy as compared to those receiving amoxicillin. The fever reduction in those receiving cefdinir occurred a day earlier than in those getting amoxicillin.

CONCLUSIONS

Fever was reduced and GABHS was eradicated more rapidly from children treated with cefdinir as compared to amoxicillin.

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Authors+Show Affiliations

Brook I
Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC 20016, USA. ib6@georgetown.edu
Gober AE
No affiliation info available

MeSH

Acute DiseaseAmoxicillinAnti-Bacterial AgentsCefdinirCephalosporinsChildChild, PreschoolComorbidityDrug Therapy, CombinationFemaleFeverHemolysisHumansMalePharyngitisStreptococcal InfectionsStreptococcus pyogenesTime FactorsTonsillitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19285734

Citation

Brook, Itzhak, and Alan E. Gober. "Rate of Eradication of Group a Beta-hemolytic Streptococci in Children With Pharyngo-tonsillitis By Amoxicillin and Cefdinir." International Journal of Pediatric Otorhinolaryngology, vol. 73, no. 5, 2009, pp. 757-9.
Brook I, Gober AE. Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. Int J Pediatr Otorhinolaryngol. 2009;73(5):757-9.
Brook, I., & Gober, A. E. (2009). Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. International Journal of Pediatric Otorhinolaryngology, 73(5), 757-9. https://doi.org/10.1016/j.ijporl.2009.02.004
Brook I, Gober AE. Rate of Eradication of Group a Beta-hemolytic Streptococci in Children With Pharyngo-tonsillitis By Amoxicillin and Cefdinir. Int J Pediatr Otorhinolaryngol. 2009;73(5):757-9. PubMed PMID: 19285734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. AU - Brook,Itzhak, AU - Gober,Alan E, Y1 - 2009/03/13/ PY - 2008/12/10/received PY - 2009/02/04/revised PY - 2009/02/07/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/8/15/medline SP - 757 EP - 9 JF - International journal of pediatric otorhinolaryngology JO - Int J Pediatr Otorhinolaryngol VL - 73 IS - 5 N2 - BACKGROUND: Cephalosporins were found to be more effective than penicillins in the eradication of group A beta-hemolytic streptococcal (GABHS) from tonsillar tissues. This study investigated the effect of amoxicillin and cefdinir therapies on the rate of eradication of GABHS from the tonsils of children with acute pharyngo-tonsillitis (PT). PATIENTS AND METHODS: Of 50 children suffering from PT 25 were treated with amoxicillin (40 mg/(kg d) or 250 mg every 8 h) and 25 with cefdinir (14 mg/(kg d) or 600 mg once a day) for 10 days. Pharyngo-tonsillar cultures were obtained from all children before treatment and on the 1st, 2nd, 3rd, 4th, 7th, and 12th days. RESULTS: GABHS was eradicated more rapidly from children treated with cefdinir as compared to those receiving amoxicillin. A smaller number of patients with GABHS were found in those treated with cefdinir as compared to amoxicillin throughout the treatment period. Eradication of GABHS from 68% (8 of 25 patients) was noted in those treated with cefdinir after 2 days and those treated with amoxicillin after 4 days. The differences between the number of patients who had a bacteriological cure between those receiving cefdinir to those getting amoxicillin was statistical significant at day 4 (32% vs. 8%). At the end of therapy GABHS was recovered from 5 (20%) and 2 (8%) of the patients. The group that received cefdinir, had a more rapid reduction in fever on the first after initiation of therapy as compared to those receiving amoxicillin. The fever reduction in those receiving cefdinir occurred a day earlier than in those getting amoxicillin. CONCLUSIONS: Fever was reduced and GABHS was eradicated more rapidly from children treated with cefdinir as compared to amoxicillin. SN - 1872-8464 UR - https://www.unboundmedicine.com/medline/citation/19285734/Rate_of_eradication_of_group_A_beta_hemolytic_streptococci_in_children_with_pharyngo_tonsillitis_by_amoxicillin_and_cefdinir_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(09)00070-6 DB - PRIME DP - Unbound Medicine ER -