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Polymorphism studies of six miniSTR loci for three ethnic populations in Singapore.
Leg Med (Tokyo). 2009 Jul; 11(4):195-7.LM

Abstract

MiniSTR loci have been demonstrated to be an effective approach in recovering genetic information from degraded specimen, because of the improved PCR efficiency of their reduced PCR amplicon sizes. This study constructed two miniSTR panels comprising six miniSTR loci, including D2S1776, D3S4529, D6S474, D9S2157, D10S1435 and D12ATA63. The allele frequency distribution, forensic parameters and heterozygosity in three Singapore populations are reported in this paper. All six loci showed relatively high polymorphism with observed heterozygosity > 0.7. However, many of these six loci also demonstrated significant population differentiation for the three populations.

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Authors+Show Affiliations

Yong RY
Defence Medical & Environmental Research Institute, DSO National Laboratories, DSO (Kent Ridge) Building, 27 Medical Drive #13-00 Singapore, Singapore 117510, Singapore. ritayong@dso.org.sg
Gan LS
No affiliation info available
Chua EM
No affiliation info available
Yap EP
No affiliation info available

MeSH

DNA FingerprintingEthnic GroupsGene FrequencyGenetics, PopulationHumansPolymerase Chain ReactionPolymorphism, GeneticSingaporeTandem Repeat Sequences

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19285901

Citation

Yong, Rita Y Y., et al. "Polymorphism Studies of Six miniSTR Loci for Three Ethnic Populations in Singapore." Legal Medicine (Tokyo, Japan), vol. 11, no. 4, 2009, pp. 195-7.
Yong RY, Gan LS, Chua EM, et al. Polymorphism studies of six miniSTR loci for three ethnic populations in Singapore. Leg Med (Tokyo). 2009;11(4):195-7.
Yong, R. Y., Gan, L. S., Chua, E. M., & Yap, E. P. (2009). Polymorphism studies of six miniSTR loci for three ethnic populations in Singapore. Legal Medicine (Tokyo, Japan), 11(4), 195-7. https://doi.org/10.1016/j.legalmed.2009.02.030
Yong RY, et al. Polymorphism Studies of Six miniSTR Loci for Three Ethnic Populations in Singapore. Leg Med (Tokyo). 2009;11(4):195-7. PubMed PMID: 19285901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphism studies of six miniSTR loci for three ethnic populations in Singapore. AU - Yong,Rita Y Y, AU - Gan,Linda S H, AU - Chua,Elizabeth M Y, AU - Yap,Eric P H, Y1 - 2009/03/13/ PY - 2008/10/13/received PY - 2008/12/30/revised PY - 2009/02/05/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2010/1/19/medline SP - 195 EP - 7 JF - Legal medicine (Tokyo, Japan) JO - Leg Med (Tokyo) VL - 11 IS - 4 N2 - MiniSTR loci have been demonstrated to be an effective approach in recovering genetic information from degraded specimen, because of the improved PCR efficiency of their reduced PCR amplicon sizes. This study constructed two miniSTR panels comprising six miniSTR loci, including D2S1776, D3S4529, D6S474, D9S2157, D10S1435 and D12ATA63. The allele frequency distribution, forensic parameters and heterozygosity in three Singapore populations are reported in this paper. All six loci showed relatively high polymorphism with observed heterozygosity > 0.7. However, many of these six loci also demonstrated significant population differentiation for the three populations. SN - 1873-4162 UR - https://www.unboundmedicine.com/medline/citation/19285901/Polymorphism_studies_of_six_miniSTR_loci_for_three_ethnic_populations_in_Singapore_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1344-6223(09)00164-3 DB - PRIME DP - Unbound Medicine ER -