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Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15; 33(4):642-50.PN

Abstract

Rosemary, Rosmarinus officinalis L. (Labiatae) has several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including depression. In this study, the effect of the hydroalcoholic extract of the stems and leaves of this plant was investigated in two behavioral models, the forced swimming test (FST) and tail suspension test (TST) in mice. The extract of R. officinalis produced an antidepressant-like effect, since the acute treatment of mice with the extract by p.o. route significantly reduced the immobility time in the FST (100 mg/kg) and TST (10-100 mg/kg), as compared to a control group, without accompanying changes in ambulation in the open-field test. Moreover, the repeated administration (14 days) of the hydroalcoholic extract of R. officinalis by p.o. route also produced an antidepressant-like effect in the TST (100-300 mg/kg). The pretreatment of mice with p-chlorophenylalanine (PCPA, 100 mg/kg, i.p., an inhibitor of serotonin synthesis, for 4 consecutive days), NAN-190 (0.5 mg/kg, i.p., a 5-HT(1A) receptor antagonist), ketanserin (5 mg/kg, i.p., a 5-HT(2A) receptor antagonist), 1-(m-chlorophenyl) biguanide (mCPBG, 10 mg/kg, i.p., a 5-HT(3) receptor agonist), prazosin (1 mg/kg, i.p., an alpha(1-)adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), but not yohimbine (1 mg/kg, i.p., an alpha(2-)adrenoceptor antagonist) was able to reverse the anti-immobility effect of the extract (10 mg/kg, p.o.) in the TST. The combination of MDL72222, (0.1 mg/kg, i.p., a 5-HT(3) receptor antagonist) with a sub-effective dose of the extract of R. officinalis (1 mg/kg, p.o.) produced an anti-immobility effect in the TST. The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.

Authors+Show Affiliations

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19286446

Citation

Machado, Daniele G., et al. "Antidepressant-like Effect of the Extract of Rosmarinus Officinalis in Mice: Involvement of the Monoaminergic System." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 33, no. 4, 2009, pp. 642-50.
Machado DG, Bettio LE, Cunha MP, et al. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(4):642-50.
Machado, D. G., Bettio, L. E., Cunha, M. P., Capra, J. C., Dalmarco, J. B., Pizzolatti, M. G., & Rodrigues, A. L. (2009). Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33(4), 642-50. https://doi.org/10.1016/j.pnpbp.2009.03.004
Machado DG, et al. Antidepressant-like Effect of the Extract of Rosmarinus Officinalis in Mice: Involvement of the Monoaminergic System. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):642-50. PubMed PMID: 19286446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. AU - Machado,Daniele G, AU - Bettio,Luis E B, AU - Cunha,Mauricio P, AU - Capra,Juliano C, AU - Dalmarco,Juliana B, AU - Pizzolatti,Moacir G, AU - Rodrigues,Ana Lúcia S, Y1 - 2009/03/13/ PY - 2008/11/14/received PY - 2009/02/13/revised PY - 2009/03/03/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/8/11/medline SP - 642 EP - 50 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 33 IS - 4 N2 - Rosemary, Rosmarinus officinalis L. (Labiatae) has several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including depression. In this study, the effect of the hydroalcoholic extract of the stems and leaves of this plant was investigated in two behavioral models, the forced swimming test (FST) and tail suspension test (TST) in mice. The extract of R. officinalis produced an antidepressant-like effect, since the acute treatment of mice with the extract by p.o. route significantly reduced the immobility time in the FST (100 mg/kg) and TST (10-100 mg/kg), as compared to a control group, without accompanying changes in ambulation in the open-field test. Moreover, the repeated administration (14 days) of the hydroalcoholic extract of R. officinalis by p.o. route also produced an antidepressant-like effect in the TST (100-300 mg/kg). The pretreatment of mice with p-chlorophenylalanine (PCPA, 100 mg/kg, i.p., an inhibitor of serotonin synthesis, for 4 consecutive days), NAN-190 (0.5 mg/kg, i.p., a 5-HT(1A) receptor antagonist), ketanserin (5 mg/kg, i.p., a 5-HT(2A) receptor antagonist), 1-(m-chlorophenyl) biguanide (mCPBG, 10 mg/kg, i.p., a 5-HT(3) receptor agonist), prazosin (1 mg/kg, i.p., an alpha(1-)adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), but not yohimbine (1 mg/kg, i.p., an alpha(2-)adrenoceptor antagonist) was able to reverse the anti-immobility effect of the extract (10 mg/kg, p.o.) in the TST. The combination of MDL72222, (0.1 mg/kg, i.p., a 5-HT(3) receptor antagonist) with a sub-effective dose of the extract of R. officinalis (1 mg/kg, p.o.) produced an anti-immobility effect in the TST. The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/19286446/Antidepressant_like_effect_of_the_extract_of_Rosmarinus_officinalis_in_mice:_involvement_of_the_monoaminergic_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(09)00063-3 DB - PRIME DP - Unbound Medicine ER -