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A population-based study showing an association between gastroesophageal reflux disease and sleep problems.
Clin Gastroenterol Hepatol 2009; 7(9):960-5CG

Abstract

BACKGROUND & AIMS

Gastroesophageal reflux disease and sleep problems are common health problems in Western nations. It is important to clarify the association between sleep and gastroesophageal reflux disease, but only a few population-based studies have been conducted.

METHODS

A population-based, cross-sectional, case-control study was based on 2 large health surveys performed in the Norwegian county Nord-Trondelag in 1984-1986 and 1995-1997. Gastroesophageal reflux disease was assessed in the second survey, which included 65,333 participants (70% of the county's adult population). The 3153 persons who reported severe reflux symptoms constituted the cases, and the 40,210 persons without reflux symptoms constituted the controls. Data on insomnia, sleep problems, and several potential confounders were collected in questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using unconditional logistic regression in crude and multivariable models.

RESULTS

In models adjusted for age, sex, tobacco smoking, obesity, and socioeconomic status, positive associations were observed between presence of insomnia (OR, 3.2; 95% CI, 2.7-3.7), sleeplessness (OR, 3.3; 95% CI, 2.9-3.8), problems falling asleep (OR, 3.1; 95% CI, 2.5-3.8), and risk of gastroesophageal reflux disease. These associations were attenuated after further adjustments for anxiety, depression, myocardial infarction, angina pectoris, stroke, and gastrointestinal symptoms, but they remained statistically significant.

CONCLUSIONS

A large population-based study indicated a link between sleep problems and gastroesophageal reflux disease that might be bidirectional.

Authors+Show Affiliations

Unit of Esophageal and Gastric Research (ESOGAR), Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Catarina.Jansson@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19286481

Citation

Jansson, Catarina, et al. "A Population-based Study Showing an Association Between Gastroesophageal Reflux Disease and Sleep Problems." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 7, no. 9, 2009, pp. 960-5.
Jansson C, Nordenstedt H, Wallander MA, et al. A population-based study showing an association between gastroesophageal reflux disease and sleep problems. Clin Gastroenterol Hepatol. 2009;7(9):960-5.
Jansson, C., Nordenstedt, H., Wallander, M. A., Johansson, S., Johnsen, R., Hveem, K., & Lagergren, J. (2009). A population-based study showing an association between gastroesophageal reflux disease and sleep problems. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 7(9), pp. 960-5. doi:10.1016/j.cgh.2009.03.007.
Jansson C, et al. A Population-based Study Showing an Association Between Gastroesophageal Reflux Disease and Sleep Problems. Clin Gastroenterol Hepatol. 2009;7(9):960-5. PubMed PMID: 19286481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based study showing an association between gastroesophageal reflux disease and sleep problems. AU - Jansson,Catarina, AU - Nordenstedt,Helena, AU - Wallander,Mari-Ann, AU - Johansson,Saga, AU - Johnsen,Roar, AU - Hveem,Kristian, AU - Lagergren,Jesper, Y1 - 2009/03/13/ PY - 2008/11/12/received PY - 2009/03/02/revised PY - 2009/03/04/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/10/23/medline SP - 960 EP - 5 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 7 IS - 9 N2 - BACKGROUND & AIMS: Gastroesophageal reflux disease and sleep problems are common health problems in Western nations. It is important to clarify the association between sleep and gastroesophageal reflux disease, but only a few population-based studies have been conducted. METHODS: A population-based, cross-sectional, case-control study was based on 2 large health surveys performed in the Norwegian county Nord-Trondelag in 1984-1986 and 1995-1997. Gastroesophageal reflux disease was assessed in the second survey, which included 65,333 participants (70% of the county's adult population). The 3153 persons who reported severe reflux symptoms constituted the cases, and the 40,210 persons without reflux symptoms constituted the controls. Data on insomnia, sleep problems, and several potential confounders were collected in questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using unconditional logistic regression in crude and multivariable models. RESULTS: In models adjusted for age, sex, tobacco smoking, obesity, and socioeconomic status, positive associations were observed between presence of insomnia (OR, 3.2; 95% CI, 2.7-3.7), sleeplessness (OR, 3.3; 95% CI, 2.9-3.8), problems falling asleep (OR, 3.1; 95% CI, 2.5-3.8), and risk of gastroesophageal reflux disease. These associations were attenuated after further adjustments for anxiety, depression, myocardial infarction, angina pectoris, stroke, and gastrointestinal symptoms, but they remained statistically significant. CONCLUSIONS: A large population-based study indicated a link between sleep problems and gastroesophageal reflux disease that might be bidirectional. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/19286481/A_population_based_study_showing_an_association_between_gastroesophageal_reflux_disease_and_sleep_problems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(09)00214-6 DB - PRIME DP - Unbound Medicine ER -