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Reproducibility of leukotriene D4 inhalation challenge in asthmatics. Effect of a novel leukotriene D4/E4-antagonist (SR 2640) on leukotriene D4-induced bronchoconstriction.
Allergy. 1991 Jul; 46(5):355-61.A

Abstract

We have studied the reproducibility of a bronchial leukotriene (LT) provocation test in asthmatics, and the effect of prior treatment with an oral leukotriene D4/E4 antagonist (SR 2640) on LTD4-induced bronchoconstriction in nine asthmatics in a double-blind placebo-controlled randomized cross-over trial. The reproducibility of the bronchial leukotriene provocation test was high. For a specific patient, the replication variance is 0.2303, and the standard deviation is thus 0.4799, corresponding to 48%, i.e. one halving of the dose or half doubling of the dose. SR 2640 antagonised LTD4 induced bronchoconstriction causing a mean shift of 48% to the right of the dose-response curve as compared with placebo (95% confidence interval being 11-137%). This study demonstrates that bronchial LTD4 provocation test is a safe and reproducible method in asthmatics, and that the method can be used to detect LT-antagonism; furthermore that SR 2640 is a weak LTD4-antagonist in asthmatics.

Authors+Show Affiliations

Medical Department TTA, State University Hospital, Copenhagen, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1928658

Citation

Frølund, L, et al. "Reproducibility of Leukotriene D4 Inhalation Challenge in Asthmatics. Effect of a Novel Leukotriene D4/E4-antagonist (SR 2640) On Leukotriene D4-induced Bronchoconstriction." Allergy, vol. 46, no. 5, 1991, pp. 355-61.
Frølund L, Madsen F, Nielsen J. Reproducibility of leukotriene D4 inhalation challenge in asthmatics. Effect of a novel leukotriene D4/E4-antagonist (SR 2640) on leukotriene D4-induced bronchoconstriction. Allergy. 1991;46(5):355-61.
Frølund, L., Madsen, F., & Nielsen, J. (1991). Reproducibility of leukotriene D4 inhalation challenge in asthmatics. Effect of a novel leukotriene D4/E4-antagonist (SR 2640) on leukotriene D4-induced bronchoconstriction. Allergy, 46(5), 355-61.
Frølund L, Madsen F, Nielsen J. Reproducibility of Leukotriene D4 Inhalation Challenge in Asthmatics. Effect of a Novel Leukotriene D4/E4-antagonist (SR 2640) On Leukotriene D4-induced Bronchoconstriction. Allergy. 1991;46(5):355-61. PubMed PMID: 1928658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of leukotriene D4 inhalation challenge in asthmatics. Effect of a novel leukotriene D4/E4-antagonist (SR 2640) on leukotriene D4-induced bronchoconstriction. AU - Frølund,L, AU - Madsen,F, AU - Nielsen,J, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 355 EP - 61 JF - Allergy JO - Allergy VL - 46 IS - 5 N2 - We have studied the reproducibility of a bronchial leukotriene (LT) provocation test in asthmatics, and the effect of prior treatment with an oral leukotriene D4/E4 antagonist (SR 2640) on LTD4-induced bronchoconstriction in nine asthmatics in a double-blind placebo-controlled randomized cross-over trial. The reproducibility of the bronchial leukotriene provocation test was high. For a specific patient, the replication variance is 0.2303, and the standard deviation is thus 0.4799, corresponding to 48%, i.e. one halving of the dose or half doubling of the dose. SR 2640 antagonised LTD4 induced bronchoconstriction causing a mean shift of 48% to the right of the dose-response curve as compared with placebo (95% confidence interval being 11-137%). This study demonstrates that bronchial LTD4 provocation test is a safe and reproducible method in asthmatics, and that the method can be used to detect LT-antagonism; furthermore that SR 2640 is a weak LTD4-antagonist in asthmatics. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/1928658/Reproducibility_of_leukotriene_D4_inhalation_challenge_in_asthmatics__Effect_of_a_novel_leukotriene_D4/E4_antagonist__SR_2640__on_leukotriene_D4_induced_bronchoconstriction_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1991&volume=46&issue=5&spage=355 DB - PRIME DP - Unbound Medicine ER -