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Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20.
Pancreas 2009; 38(5):558-64P

Abstract

OBJECTIVE

Mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm of the branch duct type (IPMN-BD) differ in biological and clinical behaviors, but MCN is often misdiagnosed as IPMN-BD. The purpose of this study was to find useful markers for the differential diagnosis of MCN and IPMN-BD.

METHODS

Immunohistochemically, the expression of the 2 types of mucin (MUC) 1 (MUC1/DF3 and MUC1/CORE), MUC2, MUC5AC, MUC6, human gastric mucin (HGM), caudal-related homeobox transcription factor 2 (CDX2), CD10, cytokeratin (CK) 7, and CK20 was examined in 7 cases of MCN and 16 cases of IPMN-BD.

RESULTS

Expression frequencies in MCN and IPMN-BD were 100% versus 44% for MUC1/DF3, 86% versus 31% for MUC1/CORE, 57% versus 19% for MUC2, 86% versus 100% for MUC5AC, 57% versus 88% for MUC6, 86% versus 100% for HGM, 57% versus 0% for CDX2, 71% versus 0% for CD10, 100% versus 69% for CK7, and 86% versus 6% for CK20.

CONCLUSIONS

Mucin 1/DF3, MUC1/CORE, CDX2, CD10, and CK20 were expressed significantly more frequently in MCN than in IPMN-BD. In particular, CD10 and CK20 showed marked differences in immunohistochemical sensitivity and specificity between MCN and IPMN-BD. It is therefore proposed that CD10 and CK20 may be used for the differential diagnosis of MCN and IPMN-BD.

Authors+Show Affiliations

Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19287335

Citation

Nishigami, Takashi, et al. "Comparison Between Mucinous Cystic Neoplasm and Intraductal Papillary Mucinous Neoplasm of the Branch Duct Type of the Pancreas With Respect to Expression of CD10 and Cytokeratin 20." Pancreas, vol. 38, no. 5, 2009, pp. 558-64.
Nishigami T, Onodera M, Torii I, et al. Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20. Pancreas. 2009;38(5):558-64.
Nishigami, T., Onodera, M., Torii, I., Sato, A., Tao, L. H., Kushima, R., ... Tsujimura, T. (2009). Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20. Pancreas, 38(5), pp. 558-64. doi:10.1097/MPA.0b013e31819f3bd6.
Nishigami T, et al. Comparison Between Mucinous Cystic Neoplasm and Intraductal Papillary Mucinous Neoplasm of the Branch Duct Type of the Pancreas With Respect to Expression of CD10 and Cytokeratin 20. Pancreas. 2009;38(5):558-64. PubMed PMID: 19287335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20. AU - Nishigami,Takashi, AU - Onodera,Masayuki, AU - Torii,Ikuko, AU - Sato,Ayuko, AU - Tao,Li-Hua, AU - Kushima,Ryoji, AU - Kakuno,Ayako, AU - Kishimoto,Mitsuo, AU - Katsuyama,Eiji, AU - Fujimori,Takahiro, AU - Hirano,Hiroshi, AU - Satake,Makoto, AU - Kuroda,Nobukazu, AU - Nishiguchi,Shuhei, AU - Fujimoto,Jiro, AU - Tsujimura,Tohru, PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/9/26/medline SP - 558 EP - 64 JF - Pancreas JO - Pancreas VL - 38 IS - 5 N2 - OBJECTIVE: Mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm of the branch duct type (IPMN-BD) differ in biological and clinical behaviors, but MCN is often misdiagnosed as IPMN-BD. The purpose of this study was to find useful markers for the differential diagnosis of MCN and IPMN-BD. METHODS: Immunohistochemically, the expression of the 2 types of mucin (MUC) 1 (MUC1/DF3 and MUC1/CORE), MUC2, MUC5AC, MUC6, human gastric mucin (HGM), caudal-related homeobox transcription factor 2 (CDX2), CD10, cytokeratin (CK) 7, and CK20 was examined in 7 cases of MCN and 16 cases of IPMN-BD. RESULTS: Expression frequencies in MCN and IPMN-BD were 100% versus 44% for MUC1/DF3, 86% versus 31% for MUC1/CORE, 57% versus 19% for MUC2, 86% versus 100% for MUC5AC, 57% versus 88% for MUC6, 86% versus 100% for HGM, 57% versus 0% for CDX2, 71% versus 0% for CD10, 100% versus 69% for CK7, and 86% versus 6% for CK20. CONCLUSIONS: Mucin 1/DF3, MUC1/CORE, CDX2, CD10, and CK20 were expressed significantly more frequently in MCN than in IPMN-BD. In particular, CD10 and CK20 showed marked differences in immunohistochemical sensitivity and specificity between MCN and IPMN-BD. It is therefore proposed that CD10 and CK20 may be used for the differential diagnosis of MCN and IPMN-BD. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/19287335/Comparison_between_mucinous_cystic_neoplasm_and_intraductal_papillary_mucinous_neoplasm_of_the_branch_duct_type_of_the_pancreas_with_respect_to_expression_of_CD10_and_cytokeratin_20_ L2 - http://Insights.ovid.com/pubmed?pmid=19287335 DB - PRIME DP - Unbound Medicine ER -